Recombinant Human CRKL Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CRKL-6088H
• Product Overview: CRKL MS Standard C13 and N15-labeled recombinant protein (NP_005198) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 33.6 kDa
• AA Sequence: MSSARFDSSDRSAWYMGPVSRQEAQ TRLQGQRHGMFLVRDSSTCPGDYVL SVSENSRVSHYIINSLPNRRFKIGD QEFDHLPALLEFYKIHYLDTTTLIE PAPRYPSPPMGSVSAPNLPTAEDNL EYVRTLYDFPGNDAEDLPFKKGEIL VIIEKPEEQWWSARNKDGRVGMIPV PYVEKLVRSSPHGKHGNRNSNSYGI PEPAHAYAQPQTTTPLPAVSGSPGA AITPLPSTQNGPVFAKAIQKRVPCA YDKTALALEVGDIVKVTRMNINGQW EGEVNGRKGLFPFTHVKIFDPQNPD ENETRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CRKL CRK like proto-oncogene, adaptor protein [ Homo sapiens (human) ]
• Official Symbol: CRKL
• Synonyms: CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v crk avian sarcoma virus CT10 oncogene homolog like; crk-like protein
• Gene ID: 1399
• mRNA Refseq: NM_005207
• Protein Refseq: NP_005198
• MIM: 602007
• UniProt ID: P46109