cxcl6
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  • Official Full Name
  • Chemokine (C-X-C motif) ligand 6
  • Background
  • Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.
  • Synonyms
  • GCP2; Chemokine (C-X-C motif) ligand 6; CXCL6
Cat.#:CXCL6-2173HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCL6 Protein, GST-tagged
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Cat.#:CXCL6-123HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CXCL6, MIgG2a Fc-tagged
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Cat.#:CXCL6-133HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CXCL6, HIgG1 Fc-tagged, mutant
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Cat.#:CXCL6-143HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CXCL6, HIgG1 Fc-tagged
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Cat.#:CXCL6-27781THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL6
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Cat.#:CXCL6-7130HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL6 protein, His & T7-tagged
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Cat.#:CXCL6-75HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL6
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Cat.#:CXCL6-7166HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CXCL6 293 Cell Lysate
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Involved Pathway

CXCL6 involved in several pathways and played different roles in them. We selected most pathways CXCL6 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCL11; TNFRSF12A; CCL21; BMP7B; CCL1; IL12BA; CCR1; IRX1; CXCR6; IL24
Chemokine signaling pathway
CCR6; GRK6; CCL3L1; GSK3B; ARRB1; RAC1; CCR1; GNAI1; CCR10; CCL27
Pertussis
IRF1; MAPK9; SERPING1; RHOA; C4BPA; IL6; MAPK10; C3; Il23a; IL1A
Rheumatoid arthritis
ATP6V0D1; IL6; IL11; HLA-DQA1; IL17A; ATP6V1G1; TGFB3; HLA-DOA; HLA-DQB1; HLA-DRB3

Protein Function

CXCL6 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL6 itself. We selected most functions CXCL6 had, and list some proteins which have the same functions with CXCL6. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR chemokine receptor binding
Related Protein PF4V1; CXCL5; CXCL1; CXCL20; CXCL12; CXCL6; AMCF-II; ITCH; CXCL12B; CXCL18B
Function chemokine activity
Related Protein CXCL14; CXCL5; CCL20A.3; CCL27B; CCL20; IL-8; CCL24; CX3CL1; CCL16; CCL21B
Function heparin binding
Related Protein FMOD; CRISPLD2; EPYC; FGF12; NRP1A; CXCL10; SLIT1; FGF4; FGF9; SOST

Interacting Protein

CXCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL6.
SSX2IP

CXCL6 Related Articles

Tian, H; Huang, PX; et al. HIF-1 alpha Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 34:1536-1546(2014).
Besnard, AG; Struyf, S; et al. CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. JOURNAL OF LEUKOCYTE BIOLOGY 94:1317-1323(2013).

CXCL6 Related Gene Family

Chemokines Cytokines