CXCL6 Protein, Chemokine (C-X-C motif) ligand 6

CXCL6

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CXCL6

Official Full Name Chemokine (C-X-C motif) ligand 6
Background Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.
Synonyms GCP2; Chemokine (C-X-C motif) ligand 6; CXCL6
    • Species :
    • Human
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL6-123H Recombinant Human CXCL6, MIgG2a Fc-tagged CHO Fc
    Human CXCL6-133H Recombinant Human CXCL6, HIgG1 Fc-tagged, mutant CHO Fc
    Human CXCL6-143H Recombinant Human CXCL6, HIgG1 Fc-tagged CHO Fc
    Human CXCL6-2173H Recombinant Human CXCL6 Protein, GST-tagged Wheat Germ GST
    Human CXCL6-27781TH Recombinant Human CXCL6 E.coli N/A
    Human CXCL6-7130H Recombinant Human CXCL6 protein, His & T7-tagged E.coli His/T7
    Human CXCL6-7166HCL Recombinant Human CXCL6 293 Cell Lysate HEK293 N/A
    Human CXCL6-75H Recombinant Human CXCL6 protein E.coli N/A

    CXCL6 involved in several pathways and played different roles in them. We selected most pathways CXCL6 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction PF4V1; Flt3l; CCR9; CXCL2; CCL18; IL2RGB; CCL28; GM1987; LIF; IL12RB1
    Chemokine signaling pathway CCL24; MAPK3; PARD3; CCR1; CXCR4; CCL27; CCL15; CCR5; PTK2B; GNAI3
    Pertussis IRF8; NOS2; C1R; AMCF-II; IL23; C1QB; MAPK1; C1RA; Itgam&Itgb2; IRAK1
    Rheumatoid arthritis CD80; TNFRSF11A; IL1B; CXCL6; TLR2; Il23a; Il12b; TNFSF13B; CXCL5; MMP3; CCL3L1

    CXCL6 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL6 itself. We selected most functions CXCL6 had, and list some proteins which have the same functions with CXCL6. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor binding CXCL5; AMCF-II; PF4V1; IL8L2; CXCL3; CXCL20; CXCL12; CXCL12B; ITCH; CXCL2
    chemokine activity CCL24; CKLF; CXCL18B; CCL6; CXCL32B.1; CCL22; CCL34B.9; CCL34B.4; CCL23; CCL7
    heparin binding SFRP1; PLA2G5; FMODA; GREM2; NAV2; VTN; MSTN; SLIT1B; UBE4A; SOST

    CXCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL6.

    SSX2IP

    Tian, H; Huang, PX; et al. HIF-1 alpha Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 34:1536-1546(2014).
    Besnard, AG; Struyf, S; et al. CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. JOURNAL OF LEUKOCYTE BIOLOGY 94:1317-1323(2013).

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