Home / Products / CYLD


Official Full Name cylindromatosis (turban tumor syndrome)
Background CYLD is a cytoplasmic deubiquitinating enzyme encoded by a tumor suppressor gene altered in individuals diagnosed with cylindromatosis, a genetic condition characterized by benign tumors of skin appendages. Functional CYLD deubiquitinase regulates inflamm
Synonyms CYLD; cylindromatosis (turban tumor syndrome); CYLD1; ubiquitin carboxyl-terminal hydrolase CYLD; KIAA0849; ubiquitin specific peptidase like 2; USPL2; ubiquitin thioesterase CYLD; deubiquitinating enzyme CYLD; ubiquitin thiolesterase CYLD; ubiquitin-spec
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYLD-22H Recombinant Human CYLD Protein, His-tagged Insect Cell His
    Human CYLD-23H Recombinant Human CYLD Protein, His-tagged Insect Cell His
    Mouse Cyld-2408M Recombinant Mouse Cyld Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CYLD-3581H Recombinant Human CYLD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYLD-6438H Recombinant Human CYLD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYLD-656H Recombinant Human CYLD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYLD-11760H Recombinant Human CYLD, GST-tagged E.coli GST
    Human CYLD-2238H Recombinant Human CYLD Protein, GST-tagged Wheat Germ GST
    Human CYLD-27021TH Recombinant Human CYLD Wheat Germ N/A
    Human CYLD-3393H Recombinant Human CYLD Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYLD-668H Recombinant Human CYLD Protein, His-tagged E.coli His
    Human CYLD-737H Recombinant Human CYLD Mammalian Cell His
    Rat CYLD-1712R Recombinant Rat CYLD Protein Mammalian Cell His

    CYLD involved in several pathways and played different roles in them. We selected most pathways CYLD participated on our site, such as Canonical NF-kappaB pathway, Death Receptor Signalling, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYLD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Canonical NF-kappaB pathway CYLD; MALT1
    Death Receptor Signalling RBCK1; SHARPIN; GNB2L1; CYLD; OTULINB; TAB1; OTUD7B; TAX1BP1B; RNF31; USP2
    Immune System KIF2B; RNF144B; DEFB125; UFL1; MX2; OASL; KPNA4; ABI1A; IGHM; EIF4G2
    Innate Immune System SIGLEC15; HERC5; ABI1A; S100B; CFD; BTR06; CD300E; DEFA1; CLEC5A; CNPY3
    NOD1/2 Signaling Pathway CASP4; CYLD
    Negative regulators of RIG-I/MDA5 signaling CYLD; PCBP2; HERC5; NLRC5; TAX1BP1B; TAX1BP1; RNF135; RNF216
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways BTR12; BTR06; TXNIPA; TXNIPB; BTR02; BTR22; BTR09; BTR29; TXNIP; CYLD
    Osteoclast differentiation NOX1; SQSTM1; MITF; AKT1; STAT2; SYK; LILRA3; SFPI1; IFNAR1; PPARG

    CYLD has several biochemical functions, for example, Lys63-specific deubiquitinase activity, proline-rich region binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYLD itself. We selected most functions CYLD had, and list some proteins which have the same functions with CYLD. You can find most of the proteins on our site.

    Function Related Protein
    Lys63-specific deubiquitinase activity YOD1; CYLD; ATXN3
    proline-rich region binding PRPF40A; ABL1; YAP1; GAREM; CCND1; CSK; TCERG1; GHR; BAIAP2L1; BAIAP2
    protein binding Mill2; KISS1R; OSBP2; MSRB3; SLC30A1; ZW10; NCLN; SYTL2; EPHA7; F10
    protein kinase binding AP2A1; CDC25C; PFKFB2; ATG13; CDK5RAP3; DNM2; TICAM1; NME2; MAPT; PEBP1
    ubiquitin-specific protease activity USP44; USP18; OTUB1B; USP15; UFD1L; USP33; TNFAIP3; YOD1; OTUD6A; OTUB2
    zinc ion binding TNFAIP3; TRIM69; ITGB1BP2; NBR1; TRIM72; NR1D2; ZZZ3; MORC3B; RNF17; LIMS1

    CYLD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYLD here. Most of them are supplied by our site. Hope this information will be useful for your research of CYLD.

    TUBA1A; HDAC6; DDX58; UBC; ub6l2_human; MGEA5; CAMK2D; IKBKE; MAVS; SPATA2L; CEP192

    Guo, JY; Shinriki, S; et al. Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy. ONCOTARGET 5:6353-6364(2014).
    Thein, S; Pham, A; et al. MK regulates the deubiquitinase CYLD at the postsynaptic density. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450:550-554(2014).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy