cyld
Share
  • Official Full Name
  • cylindromatosis (turban tumor syndrome)
  • Background
  • CYLD is a cytoplasmic deubiquitinating enzyme encoded by a tumor suppressor gene altered in individuals diagnosed with cylindromatosis, a genetic condition characterized by benign tumors of skin appendages. Functional CYLD deubiquitinase regulates inflamm
  • Synonyms
  • CYLD; cylindromatosis (turban tumor syndrome); CYLD1; ubiquitin carboxyl-terminal hydrolase CYLD; KIAA0849; ubiquitin specific peptidase like 2; USPL2; ubiquitin thioesterase CYLD; deubiquitinating enzyme CYLD; ubiquitin thiolesterase CYLD; ubiquitin-spec
Cat.#:CYLD-2238HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYLD Protein, GST-tagged
+Inquiry
Cat.#:CYLD-3393HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYLD Protein, MYC/DDK-tagged
+Inquiry
Cat.#:CYLD-668HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYLD Protein, His-tagged
+Inquiry
Cat.#:CYLD-11760HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYLD, GST-tagged
+Inquiry
Cat.#:CYLD-27021THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYLD
+Inquiry
Cat.#:CYLD-737HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CYLD
+Inquiry
Cat.#:CYLD-1712RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYLD Protein
+Inquiry

Involved Pathway

CYLD involved in several pathways and played different roles in them. We selected most pathways CYLD participated on our site, such as Canonical NF-kappaB pathway, Death Receptor Signalling, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYLD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Canonical NF-kappaB pathway
CYLD; MALT1
Death Receptor Signalling
OTUD7B; TAX1BP1B; USP4; RBCK1; FAM105B; USP2; OTULINB; OTULIN; GNB2L1; SHARPIN
Immune System
KLHL21; ASB18; GBP1; LILRB3; SIGLEC9; BTR16; FCN1; EDAR; CLEC6A; TRIM56
Innate Immune System
CD180; RIPK3; NLRP3; ALCAMB; DEFB4A; PELI2; BTR12; HBL3; MGC174857; DEFA5
NOD1/2 Signaling Pathway
CYLD; CASP4
Negative regulators of RIG-I/MDA5 signaling
RNF216; NLRC5; TAX1BP1; CYLD; HERC5; PCBP2; TAX1BP1B; RNF135
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
BTR30; BTR29; BTR16; NLRP3; BTR18; TXNIPA; PANX1A; CASP4; TXNIPB; BTR06
Osteoclast differentiation
NOX1; FHL2; LILRA3; CYBB; CSF1; AKT1; CYBA; MAPK11; CAMK4; SOCS1

Protein Function

CYLD has several biochemical functions, for example, Lys63-specific deubiquitinase activity, proline-rich region binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYLD itself. We selected most functions CYLD had, and list some proteins which have the same functions with CYLD. You can find most of the proteins on our site.
Function
Related Protein
Function Lys63-specific deubiquitinase activity
Related Protein ATXN3; YOD1; CYLD
Function proline-rich region binding
Related Protein ABL1; CCND1; TCERG1; BAIAP2L1; PRPF40A; WBP4; CSK; APBB1; ABI2; GAREM
Function protein binding
Related Protein DRD1; TTR; CHMP4B; ADA; EFNA3; STAMBP; HDAC2; FBXO4; NINJ2; DTX1
Function protein kinase binding
Related Protein JAK2; CEP68; NIPAL1; GPRC5B; CCNT2B; PTPRR; Cd24a; AGAP2; ZFP36; GDF3
Function ubiquitin-specific protease activity
Related Protein USP33; USP27X; TNFAIP3; USP12; DUB1; OTUB2; OTUD5; USP44; OTUD6A; USP19
Function zinc ion binding
Related Protein POLR3K; ZNF146; CYLD; RAG1; PAM; TP53I3; ESRRGA; PMPCB; MT1; PRICKLE1

Interacting Protein

CYLD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYLD here. Most of them are supplied by our site. Hope this information will be useful for your research of CYLD.
TUBA1A; HDAC6; DDX58; UBC; ub6l2_human; MGEA5; CAMK2D; IKBKE; MAVS; SPATA2L; CEP192

CYLD Related Articles

Guo, JY; Shinriki, S; et al. Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy. ONCOTARGET 5:6353-6364(2014).
Thein, S; Pham, A; et al. MK regulates the deubiquitinase CYLD at the postsynaptic density. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450:550-554(2014).