cyp1a1
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  • Official Full Name
  • cytochrome P450, family 1, subfamily A, polypeptide 1
  • Background
  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
  • Synonyms
  • CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1; CYP1, cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 1; cytochrome P450 1A1; CP11; P1 450; P450 C; P450DX; AHH; AHRR; Aryl hydrocarbon hydroxylase; CP 11; CP1A1_HUMAN; CYP 1; CYP1; CYPIA1; Cytochrome P1 450 dioxin inducible; Cytochrome P1-450; Cytochrome P1-450 dioxin-inducible; Cytochrome P450 family 1 subfamily A polypeptide 1; Cytochrome P450 form 6; Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P450 form 6; P450 P1; Xenobiotic monooxygenase; OTTHUMP00000183469; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; P1-450; P450-C
Cat.#:CYP1A1-2244HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP1A1 Protein, GST-tagged
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Cat.#:CYP1A1-11765HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP1A1, GST-tagged
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Cat.#:CYP1A1-146HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CYP1A1
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Cat.#:CYP1A1-27558THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP1A1
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Cat.#:CYP1A1-550HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP1A1
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Cat.#:CYP1A1-724HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP1A1 protein, MYC/DDK-tagged
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Cat.#:CYP1A1-7962HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP1A1 protein, His-tagged
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Cat.#:Cyp1a1-7963MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cyp1a1 protein, His & T7-tagged
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Cat.#:CYP1A1-1715RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP1A1 Protein
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Cat.#:Cyp1a1-7964RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cyp1a1 protein, His & GST-tagged
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Cat.#:CYP1A1-1136RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP1A1 Protein, His-tagged
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Cat.#:CYP1A1-6703CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP1A1
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Cat.#:CYP1A1-7126HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP1A1 293 Cell Lysate
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Involved Pathway

CYP1A1 involved in several pathways and played different roles in them. We selected most pathways CYP1A1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1A1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AhR pathway
CYP1B1; CDKN1A; CDKN1B; CYP1A1; JUN; NQO1; CDC37; AHRR; FLG; JUND
Arachidonic acid metabolism
CBR1L; PLA2G4D; FAAH2; CBR3; PTGES; CYP2P9; PTGS1; CYP4F18; FAM213B; PTGS2B
Benzo(a)pyrene metabolism
AKR1C4; AKR1A1; CYP1A1; FAM84B; CYP1B1; AKR1C2; CYP3A4
Biological oxidations
ADH6; CYP2C19; PRKRA; GLYATL1; CYP3C1; MTRR; CYP2F1; CYP4B1; CYP2E1; CYP4T8
Chemical carcinogenesis
CYP2C9; ALDH3B1; FAM84B; UGT1A4; CYP3A41A; ALDH3A1; Nat3; UGT1A2; CYP3A5; PTGS2
Cytochrome P450 - arranged by substrate type
CYP2C18; CYP2A7; CYP2U1; CYP2A13; CYP3A5; CYP3A7-CYP3AP1; POMCB; CYP17A1; CYP11B1; CYP3C1
Estrogen metabolism
CYP1B1; ARSD; NQO1; ARSE; COMT; CYP1A1
Fatty Acid Omega Oxidation
CYP1A1; CYP2D6; CYP2A6; ADH4; ADH7; ADH1A; ADH6; CYP4A11; CYP2E1; ADH1C

Protein Function

CYP1A1 has several biochemical functions, for example, aromatase activity, demethylase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1A1 itself. We selected most functions CYP1A1 had, and list some proteins which have the same functions with CYP1A1. You can find most of the proteins on our site.
Function
Related Protein
Function aromatase activity
Related Protein CYP2C70; CYP1A4; CYP1A; CYP4Z1; FAM84B; CYP2D26; CYP2H1; CYP3A5; CYP2C9; CYP2B19
Function demethylase activity
Related Protein CYP1A1; CYP1A2; CYP3A41B; ALKBH4; KDM1A; CYP3A41A
Function enzyme binding
Related Protein HAND1; CUTA; APP; HDAC3; HSPA5; TSPAN14; NR5A1; PRKCH; PEX5; UGT1A1
Function flavonoid 3-monooxygenase activity
Related Protein CYP1A1
Function heme binding
Related Protein HBAE3; PGRMC1; CYP2AA6; CYP2AD3; CYP2J5; CYP2AD6; CYB5R4; TDO2; CYP2B6; CYP20A1
Function iron ion binding
Related Protein PTGIS; CYP1A2; NOS2; HBAD; JHDM1D; CYP4Z1; CYP4V8; CYP8B1; CYP2C70; LEPREL2
Function monooxygenase activity
Related Protein CYP4T8; PTGIS; CYP2X8; CYP2AA6; CYP4F22; CYP19A1B; CYP2B6; CYP2C54; CYP3A4; CYP3A25
Function oxidoreductase activity
Related Protein FADS3; DIO3A; GPX1B; ETFA; BCO1; CYP4F18; CREG1; CYP2A12; PYROXD1; CYP2F2
Function oxidoreductase activity, acting on diphenols and related substances as donors
Related Protein CYP1A1
Function oxygen binding
Related Protein CYP2U1; HBM; HBQ1; CYP2B6; CYP2P10; CYP2AA12; HBB-BH1; CYP2J6; CYP2E1; CYGB
Function protein binding
Related Protein LRP1; CDK1; STX6; PIP4K2B; APOA2; PTPN22; TMPRSS4; FAM109B; ALOX5; FOXO3B
Function steroid hydroxylase activity
Related Protein CYP2K18; CYP2S1; CYP2D9; CYP2X9; CYP2D6; CYP2V1; CYP2K6; CYP2AA8; CYP27A1; CYP2AA7
Function vitamin D 24-hydroxylase activity
Related Protein CYP3A4; CYP1A1; FAM84B

Interacting Protein

CYP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1A1.
CMTM5

CYP1A1 Related Articles

Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
Liu, Y; She, WM; et al. 3, 3 '-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. INTERNATIONAL IMMUNOPHARMACOLOGY 23:489-498(2014).