CYP1A1

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CYP1A1

Official Full Name cytochrome P450, family 1, subfamily A, polypeptide 1
Background This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Synonyms CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1; CYP1, cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 1; cytochrome P450 1A1; CP11; P1 450; P450 C; P450DX; AHH; AHRR; Aryl hydrocarbon hydroxylase; CP 11; CP1A1_HUMAN; CYP 1; CYP1; CYPIA1; Cytochrome P1 450 dioxin inducible; Cytochrome P1-450; Cytochrome P1-450 dioxin-inducible; Cytochrome P450 family 1 subfamily A polypeptide 1; Cytochrome P450 form 6; Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P450 form 6; P450 P1; Xenobiotic monooxygenase; OTTHUMP00000183469; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; P1-450; P450-C
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP1A1-03H Recombinant Human CYP1A1 Protein E.coli N/A
    Human CYP1A1-04H Recombinant Human CYP1A1 Protein E.coli N/A
    Dog CYP1A1-112D Recombinant Dog CYP1A1 Protein E. coli
    Human CYP1A1-2195H Recombinant Human CYP1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Cyp1a1-2412M Recombinant Mouse Cyp1a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CYP1A1-69H Recombinant Human CYP1A1 Protein E. coli
    Human CYP1A1-11765H Recombinant Human CYP1A1, GST-tagged E.coli GST
    Human CYP1A1-146H Recombinant Human CYP1A1 Mammalian Cell His
    Human CYP1A1-2244H Recombinant Human CYP1A1 Protein, GST-tagged Wheat Germ GST
    Human CYP1A1-27558TH Recombinant Human CYP1A1 Wheat Germ N/A
    Human CYP1A1-550H Recombinant Human CYP1A1 Insect Cell N/A
    Human CYP1A1-7126HCL Recombinant Human CYP1A1 293 Cell Lysate HEK293 N/A
    Human CYP1A1-724H Recombinant Human CYP1A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP1A1-7962H Recombinant Human CYP1A1 protein, His-tagged E.coli His
    Mouse Cyp1a1-7963M Recombinant Mouse Cyp1a1 protein, His & T7-tagged E.coli His/T7
    Rat CYP1A1-1715R Recombinant Rat CYP1A1 Protein Mammalian Cell His
    Rat Cyp1a1-7964R Recombinant Rat Cyp1a1 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque CYP1A1-1136R Recombinant Rhesus monkey CYP1A1 Protein, His-tagged Mammalian Cell His
    Chicken CYP1A1-6703C Recombinant Chicken CYP1A1 Mammalian Cell His

    CYP1A1 involved in several pathways and played different roles in them. We selected most pathways CYP1A1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AhR pathway AHRR; JUND; CYP1A2; NQO1; CYP1A1; CDKN1B; PTGES3; CYP1B1; FLG; CDC37
    Arachidonic acid metabolism ALOX15; HPGDS; PLA2G4A; ALOX12; PLA2G2A; PLA2G5; CYP2AD3; CYP4F3; CYP4A12A; CYP4F18
    Benzo(a)pyrene metabolism AKR1A1; AKR1C2; CYP3A4; CYP1B1; FAM84B; AKR1C4; CYP1A1
    Biological oxidations GLYAT; MTRR; CYP2C18; CYP51A1; GSTK1; CYP2J2; CYP2W1; ADH6; SULT4A1; TPMT.2
    Chemical carcinogenesis CYP2C50; CYP2C38; UGT1A7C; Nat3; UGT1A4; MGST3; CYP3A5; GSTT2; CYP2C19; GSTA4
    Cytochrome P450 - arranged by substrate type CYP4A11; CYP2K22; CYP3A5; FAM84B; CYP24A1; CYP2A13; CYP8B2; CYP26A1; CYP2J2; CYP3C1
    Estrogen metabolism COMT; ARSE; ARSD; NQO1; CYP1A1; CYP1B1
    Fatty Acid Omega Oxidation ADH7; ADH1B; ADH4; CYP1A1; CYP4A11; ADH1A; ADH1C; CYP2A6; CYP2D6; ADH6

    CYP1A1 has several biochemical functions, for example, aromatase activity, demethylase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1A1 itself. We selected most functions CYP1A1 had, and list some proteins which have the same functions with CYP1A1. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity CYP2C37; CYP3A5; CYP3A4; CYP2A13; CYP2C70; CYP19A1; FAM84B; CYP4F12; CYP2C38; CYP2D9
    demethylase activity KDM1A; CYP3A41B; CYP1A1; ALKBH4; CYP3A41A; CYP1A2
    enzyme binding USP22; DAXX; CYP3A4; HAND1; PDE4DIP; NPM2; MAP2K7; PGR; A2M; UBE2L3
    flavonoid 3-monooxygenase activity CYP1A1
    heme binding SRC; TDO2; HEBP1; CYP2A7; CYP2C19; CAT; HBAD; CYP8B1; HMOX1; CYP11C1
    iron ion binding CYP2K16; HBM; HBAA; CYP21A2; CYP2C39; CYGB1; CYP2C19; TMLHE; CYP8B1; TYW1
    monooxygenase activity FMO1; CYP2AD2; MOXD2; TPH1B; YWHAQA; TYR; CYP1A4; CYP3A43; CYP3C4; YWHAE1
    oxidoreductase activity CYP2K17; SCD5; RDH13; SNCA; CYP7A1A; CYP24A1; RDH8B; HSD3B6; DCT; CYP4V7
    oxidoreductase activity, acting on diphenols and related substances as donors CYP1A1
    oxygen binding CYP2C19; CYP2C8; NGB; CYP2K22; CYP2AD3; TDO2; CYGB2; CYP2V1; CYP2D10; HBAA
    protein binding NOX1; ABHD16A; SLC3A1; TTBK2; KIAA0408; SERPINB9; ZBTB8A; IL6; USO1; GINS4
    steroid hydroxylase activity CYP2C38; CYP2C39; FAM84B; CYP2S1; BRSK2; CYP2AA1; CYP2C8; CYP2C70; CYP2C50; CYP1A1
    vitamin D 24-hydroxylase activity CYP1A1; FAM84B; CYP3A4

    CYP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1A1.

    CMTM5

    Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
    Liu, Y; She, WM; et al. 3, 3 '-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. INTERNATIONAL IMMUNOPHARMACOLOGY 23:489-498(2014).

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