CYP1A2

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CYP1A2

Official Full Name cytochrome P450, family 1, subfamily A, polypeptide 2
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
Synonyms CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2; CP12; P3-450; P450(PA); cytochrome P450 1A2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
    • Species :
    • Dog
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP1A2-01H Recombinant Human CYP1A2 Protein E.coli N/A
    Human CYP1A2-02H Recombinant Human CYP1A2 Protein E.coli N/A
    Dog CYP1A2-119D Recombinant Dog CYP1A2 Protein E. coli
    Pig CYP1A2-132P Recombinant Pig CYP1A2 Protein E. coli
    Rat Cyp1a2-141R Recombinant Rat CYP1A2 Protein E. coli
    Mouse Cyp1a2-2413M Recombinant Mouse Cyp1a2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CYP1A2-68H Recombinant Human CYP1A2 Protein E. coli
    Human CYP1A2-10H Recombinant Human CYP1A2 Protein, His-tagged E.coli His
    Human CYP1A2-121H Recombinant Human CYP1A2 Insect Cell N/A
    Human CYP1A2-150H Recombinant Human CYP1A2, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP1A2-2245H Recombinant Human CYP1A2 Protein, GST-tagged Wheat Germ GST
    Human CYP1A2-27559TH Recombinant Human CYP1A2 Wheat Germ N/A
    Human CYP1A2-432HCL Recombinant Human CYP1A2 cell lysate N/A
    Human CYP1A2-551H Recombinant Human CYP1A2 Insect Cell N/A
    Human CYP1A2-7960H Recombinant Human CYP1A2 protein, His-tagged E.coli His
    Rat CYP1A2-1716R Recombinant Rat CYP1A2 Protein Mammalian Cell His
    Rat Cyp1a2-7961R Recombinant Rat Cyp1a2 protein, His-tagged E.coli His
    Kit-0924 CYP1A2 Blue Screening Kit N/A
    Kit-2126 Cytochrome P450 1A2 Fluorometric Activity Assay Kit N/A
    Kit-2127 Cytochrome P450 1A2 Inhibitor Screening Kit N/A

    CYP1A2 involved in several pathways and played different roles in them. We selected most pathways CYP1A2 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aflatoxin B1 metabolism FAM84B; CYP2A13; CYP1A2; PRKRA; CYP3A4
    Aflatoxin activation and detoxification ACY3; PRKRA; CYP3C1; CYP3A5; DPEP2; CYP1A2; CYP3A4; CYP3C4; DPEP1; GGTLC1
    AhR pathway AIP; CYP1A1; JUND; PTGES3; AHR; CYP1B1; FLG; CDKN1A; AHRR; CDC37
    Arachidonic acid metabolism GGT1A; CYP2AD2; CYP2P9; CYP2C38; GPX8; CBR3; CYP2C45; GGT5; CYP4A11; CYP2C39
    Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2
    Arylamine metabolism CYP1A2; NAT2
    Biological oxidations GSTK1; Sult2a6; AS3MT; CYP19A1; ADH5; FDX1; CYP4F22; SULT4A1; ADH6; SLC26A1
    Caffeine metabolism CYP2A6; UOX; NAT1; NAT; CYP1A2; XDH; Nat3; PNAT10; PNAT3; NAT2

    CYP1A2 has several biochemical functions, for example, aromatase activity, caffeine oxidase activity, demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1A2 itself. We selected most functions CYP1A2 had, and list some proteins which have the same functions with CYP1A2. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity CYP3A43; CYP2D10; CYP3A5; CYP2C38; CYP2C70; CYP2J5; CYP2U1; CYP2C18; CYP2A13; CYP1A
    caffeine oxidase activity CYP3A4; CYP2C39; CYP2C9; CYP1A2; CYP2C38; FAM84B
    demethylase activity CYP1A2; CYP1A1; ALKBH4; CYP3A41A; KDM1A; CYP3A41B
    electron carrier activity COX7A1; SH3BGRL3; GRX2; XDH; ADH5; AKR1A1; NDUFS2; TXNRD3; COX7A3; P4HA2
    enzyme binding UGT1A6; LAMP1; HDHD2; PARK7; UBE4B; PUS7; PARK2; PLAUR; KAT8; AKIRIN2
    heme binding CYP2X10.2; HBAA1; CYP2F2; HBA2; CYP4V2; HBAE1; CYP3A25; CYP2J6; DGCR8; ABCB6
    iron ion binding CYP2C19; CYP27A1; OGFOD2; CYP46A1.4; CYP2AD3; CALR; HBA2; CYP2J5; CYP26A1; FDX1
    monooxygenase activity CYP2C18; CYP2AA9; CYP46A1.4; CYP2K22; CYP2E1; CYP2AA12; CYP2X10.2; MOXD2; CYP2P8; CYP3C1L2
    oxidoreductase activity CYP2V1; CBR1L; HSD11B1L; MPX; FLJ13639; MOXD1L; CYP19A1B; RFESD; CYP2N13; CYBASC3
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2K17; CYP2J5; CYP2C38; CYP2AA7; CYP2P6; CYP2E1; CYP2D9; CYP2F1; CYP1D1; CYP2K16

    CYP1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1A2.

    von der Heyde, S; Wagner, S; et al. mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer. PLOS ONE 10:-(2015).
    Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).

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