cyp1a2
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  • Official Full Name
  • cytochrome P450, family 1, subfamily A, polypeptide 2
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
  • Synonyms
  • CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2; CP12; P3-450; P450(PA); cytochrome P450 1A2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
Cat.#:CYP1A2-10HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP1A2 Protein, His-tagged
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Cat.#:CYP1A2-2245HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP1A2 Protein, GST-tagged
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Cat.#:CYP1A2-01HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CYP1A2 Protein
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Cat.#:CYP1A2-02HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CYP1A2 Protein
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Cat.#:CYP1A2-121HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP1A2
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Cat.#:CYP1A2-150HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP1A2, MYC/DDK-tagged
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Cat.#:CYP1A2-27559THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP1A2
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Cat.#:CYP1A2-551HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP1A2
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Cat.#:CYP1A2-7960HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP1A2 protein, His-tagged
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Cat.#:CYP1A2-1716RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP1A2 Protein
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Cat.#:Cyp1a2-7961RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cyp1a2 protein, His-tagged
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Cat.#:CYP1A2-432HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CYP1A2 cell lysate
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Cat.#:Kit-2126Tag:N/A
Source (Host):Species:
Product nameCytochrome P450 1A2 Fluorometric Activity Assay Kit
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Cat.#:Kit-2127Tag:N/A
Source (Host):Species:
Product nameCytochrome P450 1A2 Inhibitor Screening Kit
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Cat.#:Kit-0924Tag:N/A
Source (Host):Species:
Product nameCYP1A2 Blue Screening Kit
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Involved Pathway

CYP1A2 involved in several pathways and played different roles in them. We selected most pathways CYP1A2 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aflatoxin B1 metabolism
CYP2A13; CYP3A4; PRKRA; CYP1A2; FAM84B
Aflatoxin activation and detoxification
CYP1A2; CYP3A4; CYP3C4; DPEP2; CYP3C1; CYP2Y3; CYP2A13; ACY3.1; ACY3; DPEP1
AhR pathway
PTGES3; CDC37; AIP; JUND; AHRR; NQO1; CYP1B1; AHR; JUN; CYP1A2
Arachidonic acid metabolism
EPHX2; PTGS2; CYP2C54; PLA2G1B; LTC4S; ALOX5; PLA2G2D; CYP4F18; ALOX12E; PTGS1
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
CYP1A2
Arylamine metabolism
NAT2; CYP1A2
Biological oxidations
FDXR; FDX1L; CYP2K6; SLC35B3; CYP2C18; CYP27B1; DPEP1; CYP2U1; NAT2; CYP4B1
Caffeine metabolism
NAT; PNAT3; PNAT10; UOX; Nat3; NAT2; CYP2A6; NAT1; CYP1A2; XDH

Protein Function

CYP1A2 has several biochemical functions, for example, aromatase activity, caffeine oxidase activity, demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1A2 itself. We selected most functions CYP1A2 had, and list some proteins which have the same functions with CYP1A2. You can find most of the proteins on our site.
Function
Related Protein
Function aromatase activity
Related Protein CYP3A7; CYP2C38; CYP2A13; CYP4B1; CYP2D10; CYP1A4; CYP2A7; CYP2J2; FAM84B; CYP2U1
Function caffeine oxidase activity
Related Protein CYP2C38; CYP2C39; CYP2C9; CYP1A2; CYP3A4; FAM84B
Function demethylase activity
Related Protein CYP3A41A; CYP1A1; CYP1A2; CYP3A41B; KDM1A; ALKBH4
Function electron carrier activity
Related Protein XDH; GLRX; PHGDH; DHDH; NDUFA12; ACADS; ACADVL; NDUFS3; CIAPIN1; AKR7A3
Function enzyme binding
Related Protein DDX5; JUND; UGT1A6B; CASP2; PAWR; HDAC2; UGT1A7; SLC18A1; ACAT1; RAD9A
Function heme binding
Related Protein CYP4A12A; CYP2C38; CYP2V1; CYP2C70; HBB; CYP21A1; CYP2R1; CYP2C19; CYP2B6; CYP17A1
Function iron ion binding
Related Protein CYP2AA1; CYP4T8; ISCUB; BBOX1; CYP2P7; PPEF2; CYP1B1; CYP2K19; FAM84B; TPH1A
Function monooxygenase activity
Related Protein CYP4V7; CYP2K6; TH2; CYP2X9; CYP2B6; CYP19A1A; CYP2C19; FAM84B; CYP4F3; CYP2AA6
Function oxidoreductase activity
Related Protein CYP2AA12; DIO3; HSD3B6; ADOB; YWHAE1; PPM1NA; PYROXD1; AKR1C21; CYP2P9; GMPR2
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2AD6; CYP3C1; CYP2K16; CYP2X7; CYP1D1; CYP1A; CYP2AA2; CYP2D26; CYP2B6; CYP2P7

CYP1A2 Related Articles

von der Heyde, S; Wagner, S; et al. mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer. PLOS ONE 10:-(2015).
Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).