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Recombinant Human CYP1A2 Protein, His-tagged

Cat.No. : CYP1A2-10H
Product Overview : Recombinant Human CYP1A2 fused with His tag at the N-terminus was produced in E. coli.
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
Source : E. coli
Species : Human
Tag : His
Form : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Purity : > 95%
Applications : Cell culture; Activity Assays
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 [ Homo sapiens ]
Official Symbol : CYP1A2
Synonyms : CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 2; cytochrome P450 1A2; CP12; P3 450; CYPIA2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; P3-450; P450(PA);
Gene ID : 1544
mRNA Refseq : NM_000761
Protein Refseq : NP_000752
UniProt ID : P05177

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CYP1A2 interact with other cytochrome P450 enzymes in metabolic pathways? 12/29/2022

CYP1A2 collaborates with other P450 enzymes in metabolic processes.

What is the impact of altered CYP1A2 activity on liver function and disease risk? 10/20/2022

Changes in CYP1A2 activity can affect liver health and disease risk.

How do genetic variations in CYP1A2 affect drug metabolism and response? 09/23/2021

Genetic differences in CYP1A2 influence drug metabolism and individual medication responses.

What is the primary role of CYP1A2 in xenobiotic metabolism? 09/06/2021

CYP1A2 is key in metabolizing drugs and environmental chemicals.

What role does CYP1A2 play in the detoxification of environmental toxins? 01/29/2020

CYP1A2 helps detoxify harmful environmental substances.

How does CYP1A2 contribute to the metabolism of caffeine and other dietary compounds? 06/08/2019

It metabolizes caffeine and certain dietary compounds, affecting their bodily impact.

What potential therapeutic applications arise from understanding CYP1A2 activity in personalized medicine? 08/11/2017

CYP1A2's role can inform personalized medicine, tailoring drug therapies to individual metabolic profiles.

Customer Reviews (3)

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10/15/2022

    Enables data-driven decisions. Elevates research standards.

    08/02/2021

      Invaluable for insights. Highly recommended for research.

      10/23/2020

        Swift and accurate service. Supports research credibility.

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