|Official Full Name||calpain 2, (m/II) large subunit|
|Background||The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5 UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]|
|Synonyms||CAPN2; calpain 2, (m/II) large subunit; CANP2; mCANP; CANPL2; CANPml; calpain-2 catalytic subunit; CANP 2; M-calpain; calpain M-type; millimolar-calpain; calpain-2 large subunit; calpain 2, large subunit; calpain large polypeptide L2; calpain, large polypeptide L2; calpain 2, large [catalytic] subunit; calcium-activated neutral proteinase 2;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Capn2 involved in several pathways and played different roles in them. We selected most pathways Capn2 participated on our site, such as Protein processing in endoplasmic reticulum, Apoptosis, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Capn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Protein processing in endoplasmic reticulum||TRAF2; DNAJC10; DNAJA2; UBQLN3; LMAN2; SSR4; DNAJC5G; SEC24B; UBE2D1B; MAN1A1|
|Apoptosis||E2F1; HIST1H1D; TNF; CFLARA; PPP3CC; PKP1; FASLG; NTRK1; ATM; IRAK4|
|Focal adhesion||PIK3R5; DIAPH1; SOS1; SHC4; PTEN; MYLPFB; BIRC3; ACTN2; BADB; CAV3|
|Alzheimers disease||NDUFA4; CALML5; NDUFB8; COX7A2; ATP5A1; EIF2AK3; NDUFA6; GRIN2C; NDUFA12; LPL|
Capn2 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Capn2 itself. We selected most functions Capn2 had, and list some proteins which have the same functions with Capn2. You can find most of the proteins on our site.
|calcium ion binding||FBLN7; PCDH2AB9; CALM3A; NOTCH1A; EFHD1; CASQ1; CDH8; MYL12A; THBS3B; EFCAB4B|
|calcium-dependent cysteine-type endopeptidase activity||CAPN10; CAPN3; CAPNS1A; CAPN5A; SRI; CAPN2; CAPN5; GCA; CAPN2B; CAPN12|
|cysteine-type peptidase activity||OTUD7A; CASPBL; ESPL1; PSD; CAPN3; CASP7; CTSSB.1; USP17L1P; CTSC; PGPEP1|
|cytoskeletal protein binding||Fert2; EPB41L4B; FLNC; PTPN4; PACSIN1; FARP2; ALDOA; NCKIPSD; ANXA2; PKD2|
|protein binding||KPNB1; BACH1; MSN; BRIP1; FOXR1; TRAP1; ILF2; NCL; RASGRP3; TNFAIP3|
|protein heterodimerization activity||H2AFB3; H2-AA; MAFGA; GABPA; ODZ4; AXL; HIST1H2AF; RRAGA; UGT1A3; DMRTA2|
Capn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Capn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Capn2.
CAPNS1; ZDHHC17; PTPN1; TNS1; CAST; NMT1; SUMO1; 15-deoxy-delta(12,14; JAK3; CHORDC1