capn2
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  • Official Full Name
  • calpain 2, (m/II) large subunit
  • Background
  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5 UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms
  • CAPN2; calpain 2, (m/II) large subunit; CANP2; mCANP; CANPL2; CANPml; calpain-2 catalytic subunit; CANP 2; M-calpain; calpain M-type; millimolar-calpain; calpain-2 large subunit; calpain 2, large subunit; calpain large polypeptide L2; calpain, large polypeptide L2; calpain 2, large [catalytic] subunit; calcium-activated neutral proteinase 2;
Cat.#:CAPN2-122HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAPN2 protein, His-tagged
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Cat.#:CAPN2-0363HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CAPN2 Protein, GST-Tagged
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Cat.#:CAPN2-587HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAPN2 Protein, His-tagged
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Cat.#:CAPN2-001PTag:His
Source (Host):E.coliSpecies:Pig
Product nameRecombinant Pig CAPN2 Protein, His-tagged
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Cat.#:CAPN2-10702HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAPN2, GST-tagged
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Cat.#:CAPN2-123HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CAPN2, MYC/DDK-tagged
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Cat.#:CAPN2-27400THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CAPN2
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Cat.#:CAPN2-2694MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAPN2 Protein
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Cat.#:CAPN2-1121RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CAPN2 Protein
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Cat.#:CAPN2-358CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CAPN2 Protein, His-tagged
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Cat.#:CAPN2-625RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CAPN2 Protein, His-tagged
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Cat.#:CAPN2-6637CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CAPN2
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Cat.#:Capn2-2632RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Calpain 2
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Cat.#:CAPN2-350BTag:N/A
Source (Host):Bovine Myocardium.Species:Bovine
Product nameNative Bovine CAPN2
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Cat.#:CAPN2-22PTag:
Source (Host):Porcine kidneySpecies:Porcine
Product nameNative Porcine CAPN2 protein
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Cat.#:CAPN2-7863HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CAPN2 293 Cell Lysate
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Involved Pathway

Capn2 involved in several pathways and played different roles in them. We selected most pathways Capn2 participated on our site, such as Protein processing in endoplasmic reticulum, Apoptosis, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Capn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
UBE2D2; DNAJB12; SEC13; UGGT2; MAN1C1; VCP; DNAJB12A; SEL1L2; HSP90AB1; BCAP31
Apoptosis
HIST1H1C; E2F1; PPP3CB; HIST1H1E; PPP3CC; CAPN1B; PRKAR2B; DIABLOA; IRF4; MYC
Focal adhesion
TLN2A; ELK1; FN1A; COL11A1A; ITGA4; THBS4; ITGA8; RAC2; PDPK1; MYLK4
Alzheimers disease
PSEN1; NDUFA5; ATP5G1; UQCRFS1; NDUFA7; CAPN2; COX6A2; COX6B1; TNF; Atp5g2

Protein Function

Capn2 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Capn2 itself. We selected most functions Capn2 had, and list some proteins which have the same functions with Capn2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein MAN1B1; SYT7B; PCDH2G5; CDH10; PROCA; TESC; CAMKK2; PLCD1A; PCDHB2; SLC25A25
Function calcium-dependent cysteine-type endopeptidase activity
Related Protein SRI; CAPN9; CAPN13; CAPN2; PDCD6; CAPN3; CAPN10; CAPN3B; PEF1; CAPN5A
Function cysteine-type peptidase activity
Related Protein CTSL1B; SENP7; CLCA3; CAPN12; OTUD4; CTSSB.1; CASP7; CTSK; CAPN2B; OTULIN
Function cytoskeletal protein binding
Related Protein FARP2; EPB4.1L4A; PKD2; MSNA; EZRA; PACSIN2; B4GALT1; FARP1; DES; NCKIPSD
Function protein binding
Related Protein NAT8B; FZD2; FAM108A1; CCDC121; RAD9; RIPPLY3; TSR2; CCDC9; NAA38; RTN4RL1
Function protein heterodimerization activity
Related Protein ZHX1; SOX4; HIST1H2BF; CAV2; KCNIP1; TAS1R1; FZD9; INHA; TAS1R3; BOKA

Interacting Protein

Capn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Capn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Capn2.
CAPNS1; ZDHHC17; PTPN1; TNS1; CAST; NMT1; SUMO1; 15-deoxy-delta(12,14; JAK3; CHORDC1