Capn2 Protein, calpain 2, (m/II) large subunit

Capn2

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Capn2

Official Full Name calpain 2, (m/II) large subunit
Background The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5 UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Synonyms CAPN2; calpain 2, (m/II) large subunit; CANP2; mCANP; CANPL2; CANPml; calpain-2 catalytic subunit; CANP 2; M-calpain; calpain M-type; millimolar-calpain; calpain-2 large subunit; calpain 2, large subunit; calpain large polypeptide L2; calpain, large polypeptide L2; calpain 2, large [catalytic] subunit; calcium-activated neutral proteinase 2;
    • Species :
    • Bovine
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rat
    • Rhesus Macaque
    • Source :
    • Bovine Myocardium
    • E.coli
    • HEK293
    • Mammalian Cell
    • Porcine kidney
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAPN2-122H Recombinant Human CAPN2 protein, His-tagged E.coli His
    Human CAPN2-0363H Recombinant Human CAPN2 Protein, GST-Tagged Wheat Germ GST
    Human CAPN2-10702H Recombinant Human CAPN2, GST-tagged E.coli GST
    Human CAPN2-123H Recombinant Human CAPN2, MYC/DDK-tagged HEK293 Myc/DDK
    Human CAPN2-27400TH Recombinant Human CAPN2 Wheat Germ N/A
    Human CAPN2-587H Recombinant Human CAPN2 Protein, His-tagged E.coli His
    Human CAPN2-7863HCL Recombinant Human CAPN2 293 Cell Lysate HEK293 N/A
    Mouse CAPN2-2694M Recombinant Mouse CAPN2 Protein Mammalian Cell His
    Rat CAPN2-1121R Recombinant Rat CAPN2 Protein Mammalian Cell His
    Rat Capn2-2632R Recombinant Rat Calpain 2 E.coli N/A
    Cynomolgus Monkey CAPN2-358C Recombinant Cynomolgus CAPN2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CAPN2-625R Recombinant Rhesus monkey CAPN2 Protein, His-tagged Mammalian Cell His
    Bovine CAPN2-350B Native Bovine CAPN2 Bovine Myocardium N/A
    Chicken CAPN2-6637C Recombinant Chicken CAPN2 Mammalian Cell His
    Pig CAPN2-001P Recombinant Pig CAPN2 Protein, His-tagged E.coli His
    Porcine CAPN2-22P Native Porcine CAPN2 protein Porcine kidney N/A

    Capn2 involved in several pathways and played different roles in them. We selected most pathways Capn2 participated on our site, such as Protein processing in endoplasmic reticulum, Apoptosis, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Capn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum TRAF2; DNAJC10; DNAJA2; UBQLN3; LMAN2; SSR4; DNAJC5G; SEC24B; UBE2D1B; MAN1A1
    Apoptosis E2F1; HIST1H1D; TNF; CFLARA; PPP3CC; PKP1; FASLG; NTRK1; ATM; IRAK4
    Focal adhesion PIK3R5; DIAPH1; SOS1; SHC4; PTEN; MYLPFB; BIRC3; ACTN2; BADB; CAV3
    Alzheimers disease NDUFA4; CALML5; NDUFB8; COX7A2; ATP5A1; EIF2AK3; NDUFA6; GRIN2C; NDUFA12; LPL

    Capn2 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Capn2 itself. We selected most functions Capn2 had, and list some proteins which have the same functions with Capn2. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding FBLN7; PCDH2AB9; CALM3A; NOTCH1A; EFHD1; CASQ1; CDH8; MYL12A; THBS3B; EFCAB4B
    calcium-dependent cysteine-type endopeptidase activity CAPN10; CAPN3; CAPNS1A; CAPN5A; SRI; CAPN2; CAPN5; GCA; CAPN2B; CAPN12
    cysteine-type peptidase activity OTUD7A; CASPBL; ESPL1; PSD; CAPN3; CASP7; CTSSB.1; USP17L1P; CTSC; PGPEP1
    cytoskeletal protein binding Fert2; EPB41L4B; FLNC; PTPN4; PACSIN1; FARP2; ALDOA; NCKIPSD; ANXA2; PKD2
    protein binding KPNB1; BACH1; MSN; BRIP1; FOXR1; TRAP1; ILF2; NCL; RASGRP3; TNFAIP3
    protein heterodimerization activity H2AFB3; H2-AA; MAFGA; GABPA; ODZ4; AXL; HIST1H2AF; RRAGA; UGT1A3; DMRTA2

    Capn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Capn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Capn2.

    CAPNS1; ZDHHC17; PTPN1; TNS1; CAST; NMT1; SUMO1; 15-deoxy-delta(12,14; JAK3; CHORDC1

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