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DEFA1

  • Official Full Name

    defensin, alpha 1

  • Overview

    Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
  • Synonyms

    DEFA1; defensin, alpha 1; DEF1, DEFA2, defensin, alpha 1, myeloid related sequence , defensin, alpha 2 , MRS; neutrophil defensin 1; HNP 1; DEF1; DEFA2; Defensin 1; HNP1; HP1; MRS; defensin, alpha 2; OTTHUMP00000196017; myeloid-related sequence; defensin, alpha 1, myeloid-related sequence; HP-1; HNP-1; DEFA1B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Duckbill platypus
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • KSI
  • Myc|DDK
  • N/A
  • Strep
  • Twin
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DEFA1-26678TH Recombinant Human DEFA1 E.coli N/A
Human DEFA1-2155H Recombinant Human DEFA1, GST-tagged Wheat Germ GST
Human DEFA1-26186TH Recombinant Human DEFA1, His-tagged E.coli His
Human DEFA1-454H Recombinant Human DEFA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DEFA1-2140H Recombinant Human Defensin, Alpha 1 Mammalian Cell N/A
Human DEFA1-955H Recombinant Human Defensin, Alpha 1 E.coli N/A
Human DEFA1-4893H Recombinant Human DEFA1 protein, His-tagged E.coli His Glu20~Cys94
Human DEFA1-6991HCL Recombinant Human DEFA1 293 Cell Lysate HEK293 N/A
Human DEFA1-2811H Recombinant Human DEFA1 protein, GST-tagged E.coli GST 1-94aa
Human DEFA1-1618H Recombinant Human DEFA1 protein, His & GST-tagged E.coli His/GST Gln18~Cys94 (Accession # P59665)
Human DEFA1-6903HF Recombinant Full Length Human DEFA1 Protein, GST-tagged In Vitro Cell Free System GST 94 amino acids
Human DEFA1-0542H Recombinant Human DEFA1 protein, Twin-Strep-tagged HEK293 Twin-Strep Asp39-Cys94
Human DEFA1-1930H Recombinant Human DEFA1 protein, Strep-tagged HEK293 Strep Asp 39 - Cys 94
Human DEFA1-1939H Recombinant Human DEFA1 Protein (Glu20-Cys94), His tagged E.coli His Glu20-Cys94
Mouse DEFA1-4444M Recombinant Mouse DEFA1 Protein Mammalian Cell His
Mouse Defa1-3345M Recombinant Mouse Defa1, His-tagged E.Coli or Yeast His 93
Mouse Defa1-1825M Recombinant Mouse Defa1 protein, His & GST-tagged E.coli His/GST Asp20~Arg93
Mouse DEFA1-2285M-B Recombinant Mouse DEFA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse DEFA1-2285M Recombinant Mouse DEFA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DEFA1-2194M Recombinant Mouse DEFA1 Protein (59-93 aa), GST-tagged Yeast GST 59-93 aa
Mouse Defa1-2812M Recombinant Mouse Defa1 protein, His-GST-tagged E.coli His/GST 59-93aa
Duckbill platypus DefA1-3830D Recombinant Duckbill platypus DefA1 protein, His-KSI-tagged E.coli His-KSI 63-94aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DEFA1 Related Articles
  • DEFA1 Related Research Area

DEFA1 involved in several pathways and played different roles in them. We selected most pathways DEFA1 participated on our site, such as Alpha-defensins, Cellular roles of Anthrax toxin, Defensins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alpha-defensinsDEFA6;DEFA1;ART1;DEFA5;DEFA3
Cellular roles of Anthrax toxinANTXR2;DEFA1;ANTXR1
DefensinsDEFA6;DEFB4A;ART1;DEFB103A;DEFA3;DEFB116;DEFA1;DEFB129;DEFB121
Immune SystemSPSB4;EIF4G2;AP1G1;PRLRB;KLRG1;CD160;KIF3B;LRR1;FCN2
Innate Immune SystemCYLD;TXNIP;MGC174857;MGC174152;CTS7;FAM49BA;CFHL3;WIPF3;LY86

DEFA1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFA1 itself. We selected most functions DEFA1 had, and list some proteins which have the same functions with DEFA1. You can find most of the proteins on our site.

Function Related Protein

DEFA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA1.

Dynll1; PFDN1; ZNF16; GSK3B; P/V/C

Savilahti, EM; Kukkonen, AK; et al. Soluble CD14, alpha-and beta-defensins in breast milk: Association with the emergence of allergy in a high-risk population. INNATE IMMUNITY 21:332-337(2015).
Xu, SZ; Lee, SH; et al. Effects of dietary selenium on host response to necrotic enteritis in young broilers. RESEARCH IN VETERINARY SCIENCE 98:66-73(2015).
  • Q&As
  • Reviews

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Customer Reviews (3)

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Reviews
08/06/2020

    It provides a reliable foundation for my studies.

    08/02/2019

      Both in terms of performance and quality, this protein reagent has excelled. 

      01/25/2019

        This protein substance is truly remarkable! Its exceptional stability and performance have greatly enhanced the convenience and accuracy of my scientific research.

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