DEFA1 Protein, defensin, alpha 1


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Official Full Name defensin, alpha 1
Background Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Synonyms DEFA1; defensin, alpha 1; DEF1, DEFA2, defensin, alpha 1, myeloid related sequence , defensin, alpha 2 , MRS; neutrophil defensin 1; HNP 1; DEF1; DEFA2; Defensin 1; HNP1; HP1; MRS; defensin, alpha 2; OTTHUMP00000196017; myeloid-related sequence; defensin, alpha 1, myeloid-related sequence; HP-1; HNP-1; DEFA1B
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse DEFA1-2194M Recombinant Mouse DEFA1 Protein (59-93 aa), GST-tagged Yeast GST
    Human DEFA1-1618H Recombinant Human DEFA1 protein, His & GST-tagged E.coli His/GST
    Human DEFA1-2140H Recombinant Human Defensin, Alpha 1 Mammalian Cell N/A
    Human DEFA1-2155H Recombinant Human DEFA1, GST-tagged Wheat Germ GST
    Human DEFA1-26186TH Recombinant Human DEFA1, His-tagged E.coli His
    Human DEFA1-26678TH Recombinant Human DEFA1 E.coli N/A
    Human DEFA1-454H Recombinant Human DEFA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DEFA1-4893H Recombinant Human DEFA1 protein, His-tagged E.coli His
    Human DEFA1-6991HCL Recombinant Human DEFA1 293 Cell Lysate HEK293 N/A
    Human DEFA1-955H Recombinant Human Defensin, Alpha 1 E.coli N/A
    Mouse Defa1-1825M Recombinant Mouse Defa1 protein, His & GST-tagged E.coli His/GST
    Mouse Defa1-3345M Recombinant Mouse Defa1, His-tagged E.Coli or Yeast His
    Mouse DEFA1-4444M Recombinant Mouse DEFA1 Protein Mammalian Cell His

    DEFA1 involved in several pathways and played different roles in them. We selected most pathways DEFA1 participated on our site, such as Alpha-defensins, Cellular roles of Anthrax toxin, Defensins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alpha-defensins DEFA1; DEFA3; DEFA6; ART1; DEFA5
    Cellular roles of Anthrax toxin ANTXR1; DEFA1; ANTXR2
    Defensins DEFA3; DEFA1; CCR6; DEFB4B; ART1; DEFB4A; DEFB103A; DEFB104A; DEFA5; DEFA6
    Immune System KLRF1; LRR1; SPSB2; TRIM48; FBXO44; EIF4G2A; LILRB5; TRIM14; NCKIPSD; ADAR
    Innate Immune System CD300E; CLEC6A; BTR09; DEFB1; DUSP3; TNIP2; FCN3; WASF3; CFHL4; MASP2

    DEFA1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFA1 itself. We selected most functions DEFA1 had, and list some proteins which have the same functions with DEFA1. You can find most of the proteins on our site.

    Function Related Protein

    DEFA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA1.

    Dynll1; PFDN1; ZNF16; GSK3B; P/V/C

    Savilahti, EM; Kukkonen, AK; et al. Soluble CD14, alpha-and beta-defensins in breast milk: Association with the emergence of allergy in a high-risk population. INNATE IMMUNITY 21:332-337(2015).
    Xu, SZ; Lee, SH; et al. Effects of dietary selenium on host response to necrotic enteritis in young broilers. RESEARCH IN VETERINARY SCIENCE 98:66-73(2015).

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