dek
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  • Official Full Name
  • DEK oncogene
  • Background
  • This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • DEK; DEK oncogene; DEK oncogene (DNA binding); protein DEK; D6S231E; DEK gene; DEK oncogene DNA binding; DEK_HUMAN; DNA binding; OTTHUMP00000039357; OTTHUMP00000016078; OTTHUMP00000221544; OTTHUMP00000221545
Cat.#:DEK-180MTag:His
Source (Host):Baculovirus insect cellsSpecies:Mouse
Product nameRecombinant Mouse DEK protein, His-tagged
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Cat.#:DEK-2529HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DEK Protein, GST-tagged
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Cat.#:DEK-433HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DEK Protein, MYC/DDK-tagged
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Cat.#:DEK-2046HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DEK, GST-tagged
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Cat.#:DEK-1845RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DEK Protein
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Cat.#:DEK-1241RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DEK Protein, His-tagged
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Cat.#:DEK-1932CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DEK
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Cat.#:DEK-4273ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DEK
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Cat.#:DEK-6980HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DEK 293 Cell Lysate
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Protein Function

DEK has several biochemical functions, for example, DNA binding, histone binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DEK itself. We selected most functions DEK had, and list some proteins which have the same functions with DEK. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RAD51B; ZBTB44; NR0B2A; RXRGB; MBD3A; TGIF2LY; PRM2; MEIS4.1A; HOMEZ; ZFP512
Function histone binding
Related Protein ASF1A; HIST1H4E; SNCA; ANP32E; PRMT7; MYSM1; HIST1H3H; PRMT6; HIST2H4; HIST1H3E
Function poly(A) RNA binding
Related Protein MRPL42; MRPL44; FASTKD1; RTN4; ZCCHC7; PCBP2; U2SURP; CKAP4; ZFP36; PEBP1

Interacting Protein

DEK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEK here. Most of them are supplied by our site. Hope this information will be useful for your research of DEK.
DAXX; CSNK2A1; UPF1; q7cit1_yerpe; NOP56; ESR1; DBP; CSNK2A2; RPL10; HIST2H4B; HIST1H3D; NR5A1; Rpl35; MMGT1; HDAC2

DEK Related Articles

Patel, RM; Walters, LL; et al. DEK expression in Merkel cell carcinoma and small cell carcinoma. JOURNAL OF CUTANEOUS PATHOLOGY 39:753-757(2012).
Kostianets, O; Shyian, M; et al. Serological Analysis of SEREX-Defined Medullary Breast Carcinoma-Associated Antigens. CANCER INVESTIGATION 30:519-527(2012).