DEK
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Official Full Name
DEK oncogene
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Overview
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DEK; DEK oncogene; DEK oncogene (DNA binding); protein DEK; D6S231E; DEK gene; DEK oncogene DNA binding; DEK_HUMAN; DNA binding; OTTHUMP00000039357; OTTHUMP00000016078; OTTHUMP00000221544; OTTHUMP00000221545;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- MYC
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DEK Related Articles
DEK involved in several pathways and played different roles in them. We selected most pathways DEK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DEK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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DEK has several biochemical functions, for example, DNA binding, histone binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DEK itself. We selected most functions DEK had, and list some proteins which have the same functions with DEK. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF286A;DLX3B;NR5A5;MCMDC2;TGIF2;NKX2.7;FOXO1B;HIST1H2BP;ZNF777 |
histone binding | NPM2;CHD8;SET;HIST1H47;HIST1H3G;COPRS;HIST1H4K;NCAPD3;HIST2H3C |
poly(A) RNA binding | AKAP17A;NOLC1;RPS2;SF1;RALYL;TDRD9;SSRP1;RBM5;DZIP3 |
DEK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEK here. Most of them are supplied by our site. Hope this information will be useful for your research of DEK.
DAXX; CSNK2A1; UPF1; q7cit1_yerpe; NOP56; ESR1; DBP; CSNK2A2; RPL10; HIST2H4B; HIST1H3D; NR5A1; Rpl35; MMGT1; HDAC2
- Q&As
- Reviews
Q&As (5)
Ask a questionEnzyme-linked immunosorbent assay (ELISA) and immunohistochemistry are commonly used to measure DEK protein levels in clinical samples from cancer and autoimmune disease patients.
DEK protein has been shown to play a role in aberrant immune responses, leading to the development of autoimmune diseases such as lupus and rheumatoid arthritis.
DEK protein has been shown to interact with various cellular proteins, modulating signaling pathways and gene expression patterns associated with cancer and autoimmune diseases.
Mutations in the DEK gene and its regulatory regions have been identified in certain cancers, contributing to its aberrant expression and oncogenic potential.
Studies have suggested that DEK protein levels in patient samples may serve as predictive biomarkers for treatment response and resistance in cancer therapy.
Customer Reviews (3)
Write a reviewThis collaboration may extend beyond the purchase of the DEK protein, potentially leading to additional support, joint research projects, or access to expertise in the field.
This may include providing detailed protocols, troubleshooting advice, and suggestions for experimental design.
The manufacturer can provide researchers with high-quality DEK protein, ensuring it is properly purified, characterized, and quality-controlled.
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