dhx36
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  • Official Full Name
  • DEAH (Asp-Glu-Ala-His) box polypeptide 36
  • Background
  • This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • DHX36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DDX36, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 36; probable ATP-dependent RNA helicase DHX36; KIAA1488; MLEL1; G4 resolvase-1; MLE-like protein 1; DEAH box protein 36; DEAD/H (Asp-Glu-Ala-Asp/His) bo
Cat.#:DHX36-4579MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DHX36 Protein
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Involved Pathway

DHX36 involved in several pathways and played different roles in them. We selected most pathways DHX36 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA degradation
SKIV2L; EXOSC2; HSPA9; LSM5; PABPC1; ZCCHC7; CNOT10; EXOSC5; EXOSC1; ENO1B

Protein Function

DHX36 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX36 itself. We selected most functions DHX36 had, and list some proteins which have the same functions with DHX36. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RLN1; C22orf28; PRKCD; SMC3; PRKCA; UBE2D2; UBE2C; P2RX4; GC3; UBE2N
Function ATP-dependent RNA helicase activity
Related Protein UPF1; DDX53; DDX23; DDX20; G3BP1; DDX39B; DDX41; DDX54; CHST13; DHX15
Function ATP-dependent helicase activity
Related Protein DHX36; DHX37; BLM; TTF2; ERCC6L2; CHD6; RECQL5; RTEL1; SNRNP200; CHD4A
Function DNA binding
Related Protein HOXD12; FAM60AL; SRRT; POLR3A; GM239; HOXA10B; ERCC3; ZNF559; DNTTIP1; ADNPA
Function DNA-dependent ATPase activity
Related Protein MSH6; RAD51C; TOP2A; IGHMBP2; MSH5; RAD51L1; CDK7; RAD51L3; RAD51D; TTF2
Function G-quadruplex DNA binding
Related Protein LONP1; DHX36; BLM; WRN
Function G-quadruplex RNA binding
Related Protein DHX36; PATL2; Aff2; FXR1
Function RNA binding
Related Protein CSTF2; HNRNPAB; C1D; HNRNPK; EXOSC9; NHP2L1B; EIF1AXB; PAIP1; MCTS2; CNOT8
Function core promoter binding
Related Protein ARNTL; TFAP2C; NOTCH1; CCAR1; REST; HNRNPU; IFI203; MTF1; RELB; NONO
Function double-stranded RNA binding
Related Protein TARBP2; RNASEN; IFIH1; OAS2; TLR8; OASL1; AGO3; ZNF346; LRRFIP1; ADARB1
Function helicase activity
Related Protein PEO1; SMARCAD1; DHX58; SHPRH; SMARCAL1; DDX58; MCM6L; RAD54L; SETX; HLTF
Function histone deacetylase binding
Related Protein GMNN; MAPK8; HIC1; SIX3; CCND1; RAD9A; YWHAB; MAGEA2B; TOP2B; CEBPA
Function hydrolase activity
Related Protein ABHD16A; ATP1A1B; TDRD9; URAH; PPP3CCA; DDX51; ACOT10; PRSS42; ATP2B1B; PLA2G2F
Function nucleic acid binding
Related Protein SP5L; ZFP583; ZFP536; RECQL5; AGO3B; ZNF576.2; RBMS3; GTF3A; SETD1B; RBM14A
Function nucleotide binding
Related Protein EPHA4A; NME2A; DDX51; MSI1; RHOGA; NME2B.2; HNRPL; ARF4A; MSI2; CELF4
Function poly(A) RNA binding
Related Protein UTP3; SPATS2L; YWHAE; NOLC1; MRTO4; REPIN1; HIST1H4I; SLC25A11; RPL27A; RPP25L
Function protein binding
Related Protein PLK1S1; DTX3L; TRIM23; HIPK2; SLC14A2; PSMG1; EFNB1; VPS45; MAP4K4; IMPA2
Function transcription regulatory region DNA binding
Related Protein NKX2-5; GABPB2; ATF4; IKZF4; ZFHX3; TAF2; CDK5RAP2; XRCC6; AHR; CDK9

Interacting Protein

DHX36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX36 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX36.
Hmga2; Ago2

DHX36 Related Articles

Yoo, JS; Takahasi, K; et al. DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation. PLOS PATHOGENS 10:-(2014).
Booy, EP; Howard, R; et al. The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. NUCLEIC ACIDS RESEARCH 42:3346-3361(2014).