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DHX36

Official Full Name

DEAH (Asp-Glu-Ala-His) box polypeptide 36
Overview

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms

DHX36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DDX36, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 36; probable ATP-dependent RNA helicase DHX36; KIAA1488; MLEL1; G4 resolvase-1; MLE-like protein 1; DEAH box protein 36; DEAD/H (Asp-Glu-Ala-Asp/His) bo;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	DHX36-425HFL	Recombinant Full Length Human DHX36 Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	DHX36-1600H	Recombinant Human DHX36 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	DHX36-759H-B	Recombinant Human DHX36 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	DHX36-759H	Recombinant Human DHX36 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	DHX36-4579M	Recombinant Mouse DHX36 Protein	Mammalian Cell	His	Inquiry
Mouse	Dhx36-2560M	Recombinant Mouse Dhx36 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	DHX36-2367M	Recombinant Mouse DHX36 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	DHX36-2367M-B	Recombinant Mouse DHX36 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DHX36 Related Articles

DHX36 involved in several pathways and played different roles in them. We selected most pathways DHX36 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RNA degradation	RQCD1;ENO1B;MPHOSPH6;TOB1B;PABPC1A;NUDT16;CNOT4B;TTC37;LSM4

DHX36 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX36 itself. We selected most functions DHX36 had, and list some proteins which have the same functions with DHX36. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	IRAK4;UBE2L3A;KATNA1;FLAD1;TPK1;AK8;KIF13B;HIPK3B;NLRP3
ATP-dependent RNA helicase activity	DDX43;CHST13;DHX38;DDX54;DHX32;EIF4A1B;EIF4A1A;DDX21;DDX3
ATP-dependent helicase activity	RTEL1;BLM;DHX36;RECQL5;DHX37;ERCC6L2;CHD4A;TTF2;SNRNP200
DNA binding	ZFP382;TBX5B;KDM2BA;PHTF2;NR1D2B;GM14479;ZNF670;ZFP292;ZNF12
DNA-dependent ATPase activity	ERCC2;RAD51C;ERCC6;MSH3;MSH2;IGHMBP2;CHD8;DMC1;MSH6
G-quadruplex DNA binding	BLM;WRN;DHX36;LONP1
G-quadruplex RNA binding	FXR1;PATL2;DHX36;Aff2
RNA binding	OASL2;CNBPA;SMN1;ZNF239;PPARGC1B;TIAL1;SRSF9;DDX59;CPSF5
core promoter binding	EZH2;E2F2;HDAC6;HDAC1;FOXO3;KLF4;PSPC1;RELB;GADD45A
double-stranded RNA binding	DHX15;APTX;DROSHA;TUBA1B;AGO1;ZNF346;ZFP346;OAS1;MSN
helicase activity	SNRNP200;PL10;EP400;YTHDC2;MCM9;CHD9;CHD7;TDRD9;DDX51
histone deacetylase binding	ZMYND15;KLF4;TFAP4;TRAF6;MAGEA2;RAD9A;DHX36;DNMT3B;PRDM1
hydrolase activity	DHX33;CTSSB.2;RNASEL4;KLK1B22;SACM1LB;ACP5A;FAHD2A;CPSF5;ATP1A1A.4
nucleic acid binding	ZFP93;HNRNPABB;PTBP1A;ZFP622;ZEB1B;RNASE3;PRKRIRB;ACTG2;VEZF1B
nucleotide binding	MOV10B.1;SEPT9A;RAB35B;ARF1L;RHOU;GNA12A;SNRPB2;ATAD1A;CELF3
poly(A) RNA binding	CD3EAP;NOC2L;FUBP3;PUF60;TIAL1;CELF2;KCTD12;ATXN2;DDX56
protein binding	GPR37L1;RHOBTB3;TEAD4;LMLN;HPS6;PRKCA;HIST1H2BI;SLC4A1;FYCO1
transcription regulatory region DNA binding	BRCA1;TP63;MESP1;KLF2A;FOXH1;ZFP639;NCOR1;H2AFY2;TCF7L1B

DHX36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX36 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX36.

Hmga2; Ago2

Yoo, JS; Takahasi, K; et al. DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation. PLOS PATHOGENS 10:-(2014).

Booy, EP; Howard, R; et al. The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. NUCLEIC ACIDS RESEARCH 42:3346-3361(2014).