dlst
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  • Official Full Name
  • dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
  • Background
  • alpha-ketoglutarate dehydrogenase complex is a rate-regulating enzyme in the Krebs Cycle in mitochondria. Dihydrolipoamide succinyltransferase (DLST) is a key subunit in this complex. Mutations in the DLST gene may be responsible for the familial Alzheime
  • Synonyms
  • DLST; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); DLTS; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2K; OGDC-E2
Cat.#:DLST-2215HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DLST Protein, MYC/DDK-tagged
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Cat.#:DLST-2688HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DLST Protein, GST-tagged
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Cat.#:DLST-4633MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DLST Protein
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Cat.#:DLST-1280RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DLST Protein, His-tagged
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Cat.#:DLST-2116CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DLST
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Cat.#:DLST-11533ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DLST
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Cat.#:DLST-485HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DLST cell lysate
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Involved Pathway

DLST involved in several pathways and played different roles in them. We selected most pathways DLST participated on our site, such as 2-oxoglutarate decarboxylation to succinyl-CoA, Biosynthesis of antibiotics, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
2-oxoglutarate decarboxylation to succinyl-CoA
DLD; DLST
Biosynthesis of antibiotics
CMBL; GLYCTK; AMDHD2; LDHAL6A; CTH; ANI_1_2390104; DLD; pykF; ADSL; SDSL
Carbon metabolism
GLUD1; HADHAB; SUCLG2; PSAT1; HAO1; PGAM2; GOT2; PFKM; SDHD; PHGDH
Citrate cycle (TCA cycle)
SDHD; FH1; SUCLA2; PCK1; MDH2; CS; PDHA1B; OGDHA; DLST; PDHA2
Citric acid cycle (TCA cycle)
CS; DLST
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
AMDHD1; AFMID; DLST; UROC1; CRYM; SLC25A21; IDO2; PCBD1; FTCD; ACMSD
Lysine catabolism
DLST; SLC25A21; CRYM
Lysine degradation
GCDH; ALDH9A1A.1; EHMT2; SETD8A; SUV39H2; SETD7; PLOD3; WBP7; ACAT1; TMLHE

Protein Function

DLST has several biochemical functions, for example, chaperone binding, dihydrolipoyllysine-residue succinyltransferase activity, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLST itself. We selected most functions DLST had, and list some proteins which have the same functions with DLST. You can find most of the proteins on our site.
Function
Related Protein
Function chaperone binding
Related Protein CDC37; DNAJB2; DNAJA4; DNAJB5; CALR; DNAJC10; DNAJA3B; ERP29; TIMM10; DNAJA1
Function dihydrolipoyllysine-residue succinyltransferase activity
Related Protein DLST
Function heat shock protein binding
Related Protein DNAJA3; BAX; DAXX; TOMM34; GPR37; APAF1; DNAJB6; GM5506; PDXP; HSPA1A

Interacting Protein

DLST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLST here. Most of them are supplied by our site. Hope this information will be useful for your research of DLST.
IKBKE; NDRG1; USP13; UIMC1; ARIH2; PAK4; UMPS; PFN2; NAP1L1; ZBTB16; FLII; TUBB2A; q81z98_bacan; RUSC2; DLG5; SCFD1; CCDC86; ZHX1; N; 15-deoxy-delta(12,14

DLST Related Articles

Watanabe, T; Abe, M; et al. Drug-induced Liver Injury with Serious Multiform Exudative Erythema following the Use of an Over-the-counter Medication Containing Ibuprofen. INTERNAL MEDICINE 54:395-399(2015).
Shiga, T; Matsushima, T; et al. A CASE OF ERYTHEMA MULTIFORME CAUSED BY CINNAMON INCLUDED IN JAPANESE HERBAL MEDICINE, KAKKONTO. JOURNAL OF DERMATOLOGY 41:71-71(2014).