dnmt3b
Share
  • Official Full Name
  • Dnmt3b DNA methyltransferase 3B
  • Background
  • Dnmt3b (DNA (cytosine-5-)-methyltransferase 3b) has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues (epigenetics). Dnmt3b is thought to function in de novo methylation rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
  • Synonyms
  • DNMT3B; DNA methyltransferase 3B; DNA (cytosine-5)-methyltransferase 3B; m.MmuIIIB; DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB; MGC124407;
Cat.#:DNMT3B-2792HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DNMT3B Protein, GST-tagged
+Inquiry
Cat.#:DNMT3B-165HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DNMT3B, GST-tagged
+Inquiry
Cat.#:DNMT3B-26884THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DNMT3B
+Inquiry
Cat.#:DNMT3B-74HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human DNMT3B protein, GST-tagged
+Inquiry
Cat.#:Dnmt3b-1646MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dnmt3b protein, His & T7-tagged
+Inquiry
Cat.#:DNMT3B-2198CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DNMT3B
+Inquiry
Cat.#:DNMT3B-2680ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DNMT3B
+Inquiry
Cat.#:DNMT3B-6854HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DNMT3B 293 Cell Lysate
+Inquiry
Cat.#:Kit-1716Tag:N/A
Source (Host):Species:
Product nameDNMT3B Chemiluminescent Assay Kit
+Inquiry

Involved Pathway

DNMT3B involved in several pathways and played different roles in them. We selected most pathways DNMT3B participated on our site, such as Cysteine and methionine metabolism, DNA methylation, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cysteine and methionine metabolism
APIP; GOT2A; DNMT3AB; AMD1; GSS; MAT1A; BHMT; ENOPH1; MAT2AL; MRI1
DNA methylation
DNMT3B; DNMT3L; DNMT1; UHRF1; DNMT3A
Epigenetic regulation of gene expression
SUZ12A; H3F3B.1; H3F3D; UHRF1; SIN3B; AEBP2; DNMT1; PHF1; TET2; EED
Gene Expression
CHST13; ZNF433; ZNF773; RBB4L; ZNF485; BRF1B; SNAPC2; ZNF620; ZNF189; DNMT3L
Metabolic pathways
MDH1; TYRP1B; CYP2C19; RDH10A; ACAA1; UGT2A2; NOS2B; SQLE; EPRS; BTD
MicroRNAs in cancer
NOTCH3; FOXP1; SOX4; BCL2; KRAS; PDGFA; PRKCE; ABL1; HMGA2; ITGB3
Negative epigenetic regulation of rRNA expression
SAP30BP; TAF1A; RRP8; EFCAB11; SIN3B; DNMT3B; SAP30; BAZ2A; SAP30L; TAF1D
NoRC negatively regulates rRNA expression
SAP30L; TAF1C; EFCAB11; SUDS3; SAP130; BAZ2A; CD3EAP; TAF1B; DNMT1; TAF1D

Protein Function

DNMT3B has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3B itself. We selected most functions DNMT3B had, and list some proteins which have the same functions with DNMT3B. You can find most of the proteins on our site.
Function
Related Protein
Function DNA (cytosine-5-)-methyltransferase activity
Related Protein TRDMT1; DNMT1; DNMT3B; DNMT3A
Function DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
Related Protein DNMT3B; DNMT3A
Function DNA-methyltransferase activity
Related Protein DNMT3AA; NDUFAF5; DNMT3AB; DNMT4; DIMT1; PRDM12; METTL21D; DNMT1; DNMT3B; METTL8
Function chromatin binding
Related Protein PRIMPOL; GPR30; NKX6; RBMX; NSD1; EZH2; SETD7; PARP1; NEUROG1; JARID2
Function histone deacetylase binding
Related Protein CEBPA; SP1; SP2; HDAC4; NIPBL; RELA; DHX36; GMNN; ANKRA2; MYOCD
Function metal ion binding
Related Protein UNC13A; EBF1; ACAP3; KCNIP3A; PLA2G4D; ZNF592; ATP2B3A; CARNS1; OAS1; MSS51
Function protein binding
Related Protein MCM6; MPP7; UHRF1; CP110; PLEKHO1; KANSL2; MSR1; COL13A1; PACSIN3; LOC149950
Function transcription corepressor activity
Related Protein TFAP2B; CBX4; TAF9B; KLF12; DNMT3B; CIR1; HOXC6; HDAC7; CDX2; PBXIP1
Function unmethylated CpG binding
Related Protein DNMT3A; KDM2A; MLL1; CXXC1; DNMT3B

Interacting Protein

DNMT3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3B here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3B.
EZH2; EED; SUMO1; UHRF1

DNMT3B Related Articles

Gonzalez-Bosquet, J; Chu, YL; et al. Development of an Intracellular, DNA Methyltransferase-Specific, and Gene-Specific Assay for Studying Dynamic DNA Methylation. CURRENT PHARMACEUTICAL DESIGN 20:1664-1673(2014).
Zhou, HY; Li, JP; et al. Hypomethylation and Activation of Syncytin-1 Gene in Endometriotic Tissue. CURRENT PHARMACEUTICAL DESIGN 20:1786-1795(2014).