dpm1
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  • Official Full Name
  • dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
  • Background
  • Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER).Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins.Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase.Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
  • Synonyms
  • DPM1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit; dolichol-phosphate mannosyltransferase; CDGIE; MPDS; dolichol monophosphate mannose synthase; Dolichol phosphate mannose synthase; Dolichol-phosphate mannose synthase; Dolichyl phosphate beta D mannosyltransferase; dolichyl phosphate mannosyltransferase polypeptide 1; dolichyl phosphate mannosyltransferase polypeptide 1 catalytic subunit; Dolichyl-phosphate beta-D-mannosyltransferase; DPM synthase; DPM1_HUMAN; Mannose P dolichol synthase; Mannose-P-dolichol synthase; MPD synthase
Cat.#:DPM1-2836HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DPM1 Protein, GST-tagged
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Cat.#:DPM1-1023ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DPM1
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Cat.#:DPM1-6835HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DPM1 293 Cell Lysate
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Involved Pathway

DPM1 involved in several pathways and played different roles in them. We selected most pathways DPM1 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
N-Glycan biosynthesis
RPN1; ALG14; MGAT4A; ST6GAL2; DOLK; ALG8; DPAGT1; ALG13; STT3A; TUSC3
Metabolic pathways
CKMT2; GALNT5; PRIM2; NOS3; MAN1A; LDHAL6B; ALDH3A1; PNLIPRP1; PGK1; ADH1

Protein Function

DPM1 has several biochemical functions, for example, alcohol binding, dolichyl-phosphate beta-D-mannosyltransferase activity, dolichyl-phosphate-mannose-protein mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPM1 itself. We selected most functions DPM1 had, and list some proteins which have the same functions with DPM1. You can find most of the proteins on our site.
Function
Related Protein
Function alcohol binding
Related Protein DPM1; CDIPT
Function dolichyl-phosphate beta-D-mannosyltransferase activity
Related Protein DPM1; ALG5
Function dolichyl-phosphate-mannose-protein mannosyltransferase activity
Related Protein SDF2; ALG5; DPM1
Function mannose binding
Related Protein LMAN1; COLEC10; MBL1; MRC1; LMAN2; CD209C; MANBA; MBL2; DPM1; M6PR
Function protein binding
Related Protein ZWINT; NHLRC1; NPBWR2; RPL23A; TCAP; USH2A; KIF13B; HDAC7; NOS1; NR0B2

Interacting Protein

DPM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPM1.
ILK; DPM3; TDO2; MYC; PTP4A3; CIAO1; DPM2; TSC22D1; DPM3; TNFRSF14; BRF2