dsc1
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  • Official Full Name
  • desmocollin 1
  • Background
  • The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.
  • Synonyms
  • DSC1; desmocollin 1; desmocollin-1; CDHF1; cadherin family member 1; desmosomal glycoprotein 2/3; DG2/DG3
Cat.#:DSC1-476HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSC1 Protein, His-tagged
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Cat.#:Dsc1-477MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dsc1 Protein, His-tagged
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DSC1 Related Articles

Saruta, H; Ishii, N; et al. Two Cases of Pemphigus Vegetans With IgG Anti-Desmocollin 3 Antibodies. JAMA DERMATOLOGY 149:1209-1213(2013).
Arai, R; Okuda, H; et al. IgA pemphigus with non-pustular erythematous lesions and IgA antibodies to desmocollins 1 and 2. EUROPEAN JOURNAL OF DERMATOLOGY 23:362-365(2013).