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DUT

  • Official Full Name

    deoxyuridine triphosphatase

  • Overview

    This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  • Synonyms

    DUT; deoxyuridine triphosphatase; dUTP pyrophosphatase; deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial; dUTPase; dUTP nucleotidohydrolase; FLJ20622; DYNLL1; dynein, light chain, LC8-type 1; LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1; MGC126137; MGC126138; dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; dynein, cytoplasmic, light polypeptide 1; protein inhibitor of neuronal nitric oxide synthase; Dynein light chain LC8-type 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Canis lupus
  • Chicken
  • Human
  • Mouse
  • Rat
  • Streptomyces coelicolor A3(2)
  • Zebrafish
  • E. coli or Yeast
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human dUTPase-88 Active Recombinant Thermostable dUTPase E.coli N/A
Human DUT-77H Recombinant Human DUT protein, His-tagged E.coli His 70-252
Human DUT-12221H Recombinant Human DUT, GST-tagged E.coli GST 89-252a.a.
Human DUT-76H Recombinant Human DUT protein, GST-tagged E.coli GST 70-252
Human DUT-792H Recombinant Human Deoxyuridine Triphosphatase, His-tagged E.coli His
Human DUT-78H Recombinant Human DUT protein E.coli N/A 70-252
Human DUT-790H Recombinant Human DUT protein E.coli N/A Met1-Asn164
Human DUT-27878TH Recombinant Human DUT, His-tagged E.coli His 183 amino acids
Human DUT-791H Recombinant Human DUT protein, His-tagged E.coli His Met1-Asn164
Human DUT-2950H Recombinant Human DUT Protein, GST-tagged Wheat Germ GST
Human DUT-6768HCL Recombinant Human DUT 293 Cell Lysate HEK293 N/A
Human DUT-4123HF Recombinant Full Length Human DUT Protein, GST-tagged In Vitro Cell Free System GST 252 amino acids
Human DUT-3772H Recombinant Human DUT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Dut-449M Recombinant Mouse Dut Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat DUT-1979R Recombinant Rat Dut protein, His-tagged HEK293 His
Canis lupus DUT-12C Recombinant Canis lupus DUT protein, His-tagged E.coli His
Streptomyces coelicolor A3(2) DUT-1034S Recombinant Streptomyces coelicolor A3(2) DUT protein, His-tagged E. coli or Yeast His
Zebrafish DUT-1524Z Recombinant Zebrafish DUT Mammalian Cell His
Chicken DUT-3527C Recombinant Chicken DUT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DUT involved in several pathways and played different roles in them. We selected most pathways DUT participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysCYP27B1;ATP6AP1;PI4KAA;BCKDHB;INPP5E;NAGK;POLR2K;KCNG4;AK7
MetabolismADA;CYP4B1;CHST9;MARCKSA;AKR1C4;CBLC-1;NDUFAF3;APOF;MED16
Metabolism of nucleotidesPAICS;NUDT16;GLRX;TYMP;ADAL;ADK;GRX2;NUDT18;NUDT5
Pyrimidine biosynthesisDUT;DHODH
Pyrimidine metabolismNT5C1B-RDH14;DPYDB;DCK;RRM2B;TYMP;DCTPP1;UCK2B;PNP6;CANT1B
pyrimidine deoxyribonucleotides de novo biosynthesisDTYMK;DUT
pyrimidine deoxyribonucleotides de novo biosynthesis I
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesisDUT;CMPK2

DUT has several biochemical functions, for example, dUTP diphosphatase activity, magnesium ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUT itself. We selected most functions DUT had, and list some proteins which have the same functions with DUT. You can find most of the proteins on our site.

Function Related Protein
dUTP diphosphatase activity
magnesium ion bindingPRKACB;IRAK4;PKM2;FOXK2;NLK;ENO3;ALPI;TOP2A;RPS6KA2
poly(A) RNA bindingHIST1H1D;DNAJC2;HIST1H4K;COA6;GNL2;SAP18;NOP2;PTPN1;YTHDF3
protein bindingMRPL28;TPPP;VMP1;TNNC2;PRLR;NUDT22;TSHR;GPR177;PEX1

DUT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUT here. Most of them are supplied by our site. Hope this information will be useful for your research of DUT.

NUDT18; PLEKHF2; GH1; PINX1; RHOB; parE; q81k60_bacan; recN; ypdA; q81v76_bacan; yacO; q8cki1_yerpe; clpA3; fadB; cysJ; panE; epmA

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can the DUT protein be used as a biomarker in cancer diagnosis? 03/08/2022

Yes, alterations in the expression levels of the DUT protein can serve as a biomarker for certain cancers, aiding in early diagnosis and prognosis.

How does the DUT protein contribute to the understanding of neurodegenerative diseases? 10/12/2020

Research suggests a link between the DUT protein and neurodegenerative diseases, where its dysfunction may impact DNA repair processes in neurons, potentially contributing to disease progression.

Are there any specific cancer types where the DUT protein is particularly relevant? 01/14/2020

Research suggests that the DUT protein is particularly relevant in colorectal cancer, where its abnormal expression may impact DNA replication and repair mechanisms.

How is the DUT protein clinically significant in cancer research? 09/07/2019

The DUT protein is implicated in cancer research as its dysregulation can lead to an imbalance in nucleotide pools, potentially contributing to genomic instability, a common feature in cancer cells.

How does the DUT protein contribute to the development of targeted therapies in cancer treatment? 03/19/2016

Understanding the role of the DUT protein helps in developing targeted therapies that aim to modulate its activity, potentially disrupting cancer cell proliferation.

Customer Reviews (3)

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Reviews
04/01/2021

    The DUT protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.

    04/21/2020

      Another advantage of the DUT protein is its reliability and consistency, ensuring robust and reproducible results.

      05/12/2017

        Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.

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