dut
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  • Official Full Name
  • deoxyuridine triphosphatase
  • Background
  • This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  • Synonyms
  • DUT; deoxyuridine triphosphatase; dUTP pyrophosphatase; deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial; dUTPase; dUTP nucleotidohydrolase; FLJ20622; DYNLL1; dynein, light chain, LC8-type 1; LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1; MGC126137; MGC126138; dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; dynein, cytoplasmic, light polypeptide 1; protein inhibitor of neuronal nitric oxide synthase; Dynein light chain LC8-type 1
Cat.#:DUT-2950HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUT Protein, GST-tagged
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Cat.#:DUT-12221HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUT, GST-tagged
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Cat.#:DUT-27878THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUT, His-tagged
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Cat.#:DUT-76HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUT protein, GST-tagged
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Cat.#:DUT-77HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUT protein, His-tagged
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Cat.#:DUT-78HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUT protein
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Cat.#:DUT-790HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUT protein
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Cat.#:DUT-791HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUT protein, His-tagged
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Cat.#:DUT-1979RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Dut protein, His-tagged
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Cat.#:DUT-3527CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DUT
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Cat.#:DUT-1524ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUT
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Cat.#:DUT-1034STag:His
Source (Host):E. coli or YeastSpecies:Streptomyces coelicolor A3(2)
Product nameRecombinant Streptomyces coelicolor A3(2) DUT protein, His-tagged
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Cat.#:DUT-12CTag:His
Source (Host):E. coliSpecies:Canis lupus
Product nameRecombinant Canis lupus DUT protein, His-tagged
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Cat.#:DUT-792HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Deoxyuridine Triphosphatase, His-tagged
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Cat.#:dUTPase-88Tag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Thermostable dUTPase
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Cat.#:DUT-6768HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DUT 293 Cell Lysate
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Involved Pathway

DUT involved in several pathways and played different roles in them. We selected most pathways DUT participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
UCK1; POLR2G; MGAT5B; ATP5D; PYCR2; LIPCA; LPCAT1; Cel; CYP2P6; NMRK2
Metabolism
SLC25A2; ISCUB; CEPT1; SULT1C4; COX18; ACOT7; LYRM4; TPMT.2; COX7C; SULT1ST5
Metabolism of nucleotides
DPYS; NUDT16; UPP2; ADAL; DTYMK; ADSSL1; GRX2; DHODH; AK7; DCK
Pyrimidine biosynthesis
DUT; DHODH
Pyrimidine metabolism
UPP1; CANT1; POLR2G; TWISTNB; DPYDB; UCK1; NME2B.1; AK9; PNP5A; NT5C2A
pyrimidine deoxyribonucleotides de novo biosynthesis
DTYMK; DUT
pyrimidine deoxyribonucleotides de novo biosynthesis I
DUT
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
DUT; CMPK2

Protein Function

DUT has several biochemical functions, for example, dUTP diphosphatase activity, magnesium ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUT itself. We selected most functions DUT had, and list some proteins which have the same functions with DUT. You can find most of the proteins on our site.
Function
Related Protein
Function dUTP diphosphatase activity
Related Protein DUT
Function magnesium ion binding
Related Protein INPP1; IDH3B; TOP2A; CLYBL; PIF1; PPA1B; GLUL; FEN1; PRPS2; ATP10A
Function poly(A) RNA binding
Related Protein PPP1R2P9; RNPS1; CSDE1; RPL5A; MFAP1B; TRMT10C; TFB2M; RIMS1; PNO1; HTATSF1
Function protein binding
Related Protein PRSS2; INPP5A; AKT1; TTC39B; LENG1; PILRB; SH2D1A; KRT16; GLRA1; CNNM3

Interacting Protein

DUT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUT here. Most of them are supplied by our site. Hope this information will be useful for your research of DUT.
NUDT18; PLEKHF2; GH1; PINX1; RHOB; parE; q81k60_bacan; recN; ypdA; q81v76_bacan; yacO; q8cki1_yerpe; clpA3; fadB; cysJ; panE; epmA