Recombinant Human DUT Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | DUT-3772H |
Product Overview : | DUT MS Standard C13 and N15-labeled recombinant protein (NP_001939) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 17.6 kDa |
AA Sequence : | MPCSEETPAISPSKRARPAEVGGMQ LRFARLSEHATAPTRGSARAAGYDL YSAYDYTIPPMEKAVVKTDIQIALP SGCYGRVAPRSGLAAKHFIDVGAGV IDEDYRGNVGVVLFNFGKEKFEVKK GDRIAQLICERIFYPEIEEVQALDD TERGSGGFGSTGKNTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | DUT deoxyuridine triphosphatase [ Homo sapiens (human) ] |
Official Symbol : | DUT |
Synonyms : | DUT; deoxyuridine triphosphatase; dUTP pyrophosphatase; deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial; dUTPase; dUTP nucleotidohydrolase; FLJ20622; |
Gene ID : | 1854 |
mRNA Refseq : | NM_001948 |
Protein Refseq : | NP_001939 |
MIM : | 601266 |
UniProt ID : | P33316 |
Products Types
◆ Recombinant Protein | ||
DUT-2950H | Recombinant Human DUT Protein, GST-tagged | +Inquiry |
Dut-449M | Recombinant Mouse Dut Protein, MYC/DDK-tagged | +Inquiry |
DUT-78H | Recombinant Human DUT protein | +Inquiry |
DUT-12221H | Recombinant Human DUT, GST-tagged | +Inquiry |
DUT-77H | Recombinant Human DUT protein, His-tagged | +Inquiry |
◆ Lysates | ||
DUT-6768HCL | Recombinant Human DUT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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