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Recombinant Human DUT protein, His-tagged

Cat.No. : DUT-791H
Product Overview : Recombinant Human DUT(Met1-Asn164) fused with His tag at N-terminal was expressed in E. coli.
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Description : Deoxyuridine5'-TriphosphateNucleotidohydrolaseMitochondrial(dUTPase)belongstothedUTPasefamily.dUTPaseexitsasahomotrimerandisinvolvedinnucleotidemetabolism.dUTPaseproducesdUMP,theimmediateprecursorofthymidinenucleotidesanditdecreasestheintracellularconcentrationofdUTPsothaturacilcannotbeincorporatedintoDNA.ThedUTPaseincreaseinPCRproductyield,lengthandfidelityenablesfurtherdown-streamapplications.TheseeffectsmakedUTPaseusefulinPCRfidelityandyield-sensitiveapplications. dUTPase is specific for dUTP and is critical for the fidelity of DNA replication and repair.
Source : E. coli
Species : Human
Tag : His
Form : Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Protein length : Met1-Asn164
AA Sequence : MGSSHHHHHHSSGLVPRGSHMPCSE ETPAISPSKRARPAEVGGMQLRFAR LSEHATAPTRGSARAAGYDLYSAYD YTIPPMEKAVVKTDIQIALPSGCYG RVAPRSGLAAKHFIDVGAGVIDEDY RGNVGVVLFNFGKEKFEVKKGDRIA QLICERIFYPEIEEVQALDDTERGS GGFGSTGKN
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Store at < -20 centigrade, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
Shipping : The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below.
Gene Name : DUT deoxyuridine triphosphatase [ Homo sapiens ]
Official Symbol : DUT
Synonyms : DUT; deoxyuridine triphosphatase; dUTP pyrophosphatase; deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial; dUTPase; dUTP nucleotidohydrolase; FLJ20622;
Gene ID : 1854
mRNA Refseq : NM_001025248
Protein Refseq : NP_001020419
MIM : 601266
UniProt ID : P33316
Chromosome Location : 15q21.1
Pathway : Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Pyrimidine biosynthesis, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem;
Function : dUTP diphosphatase activity; hydrolase activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can the DUT protein be used as a biomarker in cancer diagnosis? 03/08/2022

Yes, alterations in the expression levels of the DUT protein can serve as a biomarker for certain cancers, aiding in early diagnosis and prognosis.

How does the DUT protein contribute to the understanding of neurodegenerative diseases? 10/12/2020

Research suggests a link between the DUT protein and neurodegenerative diseases, where its dysfunction may impact DNA repair processes in neurons, potentially contributing to disease progression.

Are there any specific cancer types where the DUT protein is particularly relevant? 01/14/2020

Research suggests that the DUT protein is particularly relevant in colorectal cancer, where its abnormal expression may impact DNA replication and repair mechanisms.

How is the DUT protein clinically significant in cancer research? 09/07/2019

The DUT protein is implicated in cancer research as its dysregulation can lead to an imbalance in nucleotide pools, potentially contributing to genomic instability, a common feature in cancer cells.

How does the DUT protein contribute to the development of targeted therapies in cancer treatment? 03/19/2016

Understanding the role of the DUT protein helps in developing targeted therapies that aim to modulate its activity, potentially disrupting cancer cell proliferation.

Customer Reviews (3)

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Reviews
04/01/2021

    The DUT protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.

    04/21/2020

      Another advantage of the DUT protein is its reliability and consistency, ensuring robust and reproducible results.

      05/12/2017

        Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.

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