defa1
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  • Official Full Name
  • defensin, alpha 1
  • Background
  • Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
  • Synonyms
  • DEFA1; defensin, alpha 1; DEF1, DEFA2, defensin, alpha 1, myeloid related sequence , defensin, alpha 2 , MRS; neutrophil defensin 1; HNP 1; DEF1; DEFA2; Defensin 1; HNP1; HP1; MRS; defensin, alpha 2; OTTHUMP00000196017; myeloid-related sequence; defensin, alpha 1, myeloid-related sequence; HP-1; HNP-1; DEFA1B
Cat.#:DEFA1-2194MTag:GST
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse DEFA1 Protein (59-93 aa), GST-tagged
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Cat.#:DEFA1-454HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DEFA1 Protein, MYC/DDK-tagged
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Cat.#:DEFA1-1618HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DEFA1 protein, His & GST-tagged
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Cat.#:DEFA1-26186THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DEFA1, His-tagged
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Cat.#:DEFA1-26678THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DEFA1
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Cat.#:DEFA1-4893HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DEFA1 protein, His-tagged
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Cat.#:Defa1-1825MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Defa1 protein, His & GST-tagged
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Cat.#:Defa1-3345MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Defa1, His-tagged
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Cat.#:DEFA1-4444MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DEFA1 Protein
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Cat.#:DEFA1-2140HTag:N/A
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human Defensin, Alpha 1
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Cat.#:DEFA1-2155HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DEFA1, GST-tagged
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Cat.#:DEFA1-955HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Defensin, Alpha 1
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Cat.#:DEFA1-6991HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DEFA1 293 Cell Lysate
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Involved Pathway

DEFA1 involved in several pathways and played different roles in them. We selected most pathways DEFA1 participated on our site, such as Alpha-defensins, Cellular roles of Anthrax toxin, Defensins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alpha-defensins
DEFA5; ART1; DEFA3; DEFA6; DEFA1
Cellular roles of Anthrax toxin
DEFA1; ANTXR1; ANTXR2
Defensins
DEFB4A; DEFB129; CCR6; DEFB116; DEFB125; DEFA3; DEFA1; DEFB121; DEFB104A; DEFB106A
Immune System
KIF20A; PANX1B; EIF4G2A; RNF34; ASB11; LRR1; BST2; TNFSF13B; ICAM4; UBE2J2
Innate Immune System
ABI2; DEFA1; DEFB119; CTS7; DEFA5; TXNIPA; LGALS3; SIRPB1; ABI1A; FCN1

Interacting Protein

DEFA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA1.
Dynll1; PFDN1; ZNF16; GSK3B; P/V/C

DEFA1 Related Articles

Savilahti, EM; Kukkonen, AK; et al. Soluble CD14, alpha-and beta-defensins in breast milk: Association with the emergence of allergy in a high-risk population. INNATE IMMUNITY 21:332-337(2015).
Xu, SZ; Lee, SH; et al. Effects of dietary selenium on host response to necrotic enteritis in young broilers. RESEARCH IN VETERINARY SCIENCE 98:66-73(2015).