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EDN1

  • Official Full Name

    endothelin 1

  • Overview

    The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    EDN1; endothelin 1; ET1; PPET1; HDLCQ7; endothelin-1; OTTHUMP00000016038; preproendothelin-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Guinea pig
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Synthetic Peptide
  • Wheat Germ
  • Yeast
  • Fc
  • Flag
  • GST
  • hFc
  • Myc
  • His
  • His (Fc)
  • Avi
  • KSI
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EDN1-245H Recombinant Human EDN1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EDN1-34H Recombinant Human EDN1 protein, GST-tagged Wheat Germ GST
Human EDN1-35H Recombinant Human EDN1 protein, His-tagged E.coli His Cys53~Ser90
Human EDN1-6721HCL Recombinant Human EDN1 293 Cell Lysate HEK293 N/A
Human EDN1-8551HFL Recombinant Full Length Human EDN1 protein, Flag-tagged Mamanlian cells Flag
Human EDN1-2802H Recombinant Human EDN1 Protein, His-tagged, BSA Conjugated Synthetic Peptide N-His
Human EDN1-3023H Recombinant Human EDN1 protein, His-tagged E.coli His 1-212 aa
Human EDN1-8305H Native Human EDN1 N/A
Human EDN1-656HF Recombinant Full Length Human EDN1 Protein, GST-tagged In Vitro Cell Free System GST 212 amino acids
Human EDN1-2026H Recombinant Human EDN1 Protein (Ala18-Trp212), His tagged E.coli His Ala18-Trp212
Mouse EDN1-4991M Recombinant Mouse EDN1 Protein Mammalian Cell His
Mouse Edn1-594M Recombinant Mouse Edn1 protein, His-tagged E.coli His Glu33~His202
Mouse EDN1-2640M Recombinant Mouse EDN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Edn1-2803M Recombinant Mouse Edn1 Protein, His-tagged, BSA Conjugated Synthetic Peptide N-His
Mouse Edn1-2729M Recombinant Mouse Edn1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse EDN1-2640M-B Recombinant Mouse EDN1 Protein Pre-coupled Magnetic Beads HEK293
Rat EDN1-2009R Recombinant Rat EDN1 Protein Mammalian Cell His
Rat Edn1-2686R Recombinant Rat Edn1 protein, His-tagged E.coli His Ser54~His202
Rat EDN1-1666R-B Recombinant Rat EDN1 Protein Pre-coupled Magnetic Beads HEK293
Rat Edn1-4228R Recombinant Rat Edn1 protein, His-KSI-tagged E.coli His-KSI 53-73aa
Rat Edn1-2805R Recombinant Rat Edn1 Protein, His-tagged, BSA Conjugated Synthetic Peptide N-His
Rat Edn1-1242R Recombinant Rat Edn1 protein, Fc-tagged Yeast Fc 53-73aa
Rat EDN1-1666R Recombinant Rat EDN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Edn1-1292R Recombinant Rat Edn1 protein, hFc-Myc-tagged HEK293 hFc-Myc 53-73aa
Rabbit EDN1-2804R Recombinant Rabbit EDN1 Protein, His-tagged, BSA Conjugated Synthetic Peptide N-His
Guinea pig Edn1-2801G Recombinant Guinea pig Edn1 Protein, His-tagged, BSA Conjugated Synthetic Peptide N-His
Zebrafish EDN1-9068Z Recombinant Zebrafish EDN1 Mammalian Cell His
Pig EDN1-2685P Recombinant Pig EDN1 protein, His-tagged E.coli His Cys53~His203 (Accession # P09558)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EDN1 Related Articles
  • EDN1 Related Research Area

EDN1 involved in several pathways and played different roles in them. We selected most pathways EDN1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), EGFR-dependent Endothelin signaling events, Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)GPR65;CXCL11.8;DRD1;EDNRB;NMBB;NPSR1;CCK;OXGR1A.3;KISS1
EGFR-dependent Endothelin signaling eventsEDNRA;EDN1
EndothelinRAMP1;ECE1;EDNRB;EDN1;EDNRA;CALCRL;CNN1;MYL1;CALCA
EndothelinsEDNRA;COL1A2;EDNRB;CYSLTR1;EDN2;EDN1;COL3A1;EDN3
G alpha (q) signalling eventsMLN;LTB4R;ADRA1D;NMBB;OPN4B;KISS1;QRFPR;GPR132;FPR-RS4
GPCR downstream signalingHCRT;OPN4.1;PROK2;ADM;RGS20;PTH2;GPR68;CYSLTR1;OR56A1
GPCR ligand bindingFPR-RS3;QRFP;CHRM4;EDN3;CCR1;CRHR2;APLN;PTH;PYYA
Gastrin-CREB signalling pathway via PKC and MAPKPROK1;GPR132B;OXTRL;GPRC6A;ANXA1C;GPR65;TAC1;MLN;NPS

EDN1 has several biochemical functions, for example, cytokine activity, endothelin A receptor binding, endothelin B receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDN1 itself. We selected most functions EDN1 had, and list some proteins which have the same functions with EDN1. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCSF3;IL17A/F3;IL21;IFNA17;SCGB3A1;GDF5;WNT5A;GREM1A;BMP8B
endothelin A receptor binding
endothelin B receptor bindingEDN3;EDN2;EDN1
hormone activityCALCA;IGF2B;LHB;CRHR2;URP2;PRL2C2;C1QTNF9;C19orf80;RLN3
protein bindingSLC22A2;TOMM7;TAGLN2;CALM3;DALRD3;HNRNPC;GRK6;TXK;FLOT1

EDN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EDN1.

EDNRB; EDNRA; BAG6; COPS6; UBQLN4

Jacobs, ME; Jeffers, LA; et al. microRNA regulation of endothelin-1 mRNA in renal collecting duct cells. LIFE SCIENCES 118:195-199(2014).
Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
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