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  • Official Full Name
  • embryonic ectoderm development
  • Background
  • This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • EED; embryonic ectoderm development; HEED; WAIT1; polycomb protein EED; WD protein associating with integrin cytoplasmic tails 1;
Cat.#:EED-1207HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EED Protein, MYC/DDK-tagged
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Cat.#:EED-3063HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EED Protein, GST-tagged
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Cat.#:EED-410HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EED Protein, His-tagged
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Cat.#:EED-316HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human EED protein, His-tagged
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Cat.#:EED-6921HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EED, His & GST tagged
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Cat.#:EED-7643HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EED, His-tagged
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Cat.#:EED-775HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EED
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Cat.#:EED-4997MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EED Protein
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Cat.#:EED-1381RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EED Protein, His-tagged
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Cat.#:EED-3027CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EED
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Cat.#:EED-2513ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EED
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Cat.#:EED-531HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EED cell lysate
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Cat.#:CBCRY07Tag:N/A
Source (Host):E. coliSpecies:
Product nameEmbryonic Ectoderm Development
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Involved Pathway

EED involved in several pathways and played different roles in them. We selected most pathways EED participated on our site, such as Cellular Senescence, Cellular responses to stress, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EED were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular Senescence
SCMH1; HIST1H1A; IGFBP7; CBX8B; PHC1; CABIN1; CDKN2A; LMNB1; H3F3D; TXN
Cellular responses to stress
HIST1H1B; CBX4; HIST4H4; RBBP7; TXNRD2; NUP50; MAP1LC3B; HSPA12B; ERF; PHC1
Chromatin modifying enzymes
BRD1; EED; MTA2; PADI3; SMYD2; ACTL6B; ACTL6A; ATF7IP; KDM4A; KAT8
Chromatin organization
DMAP1; SMARCB1A; BRD8; KIAA1267; BRPF3; PRMT6; SAP30L; KDM5D; HMG20B; SMARCE1
Epigenetic regulation of gene expression
TET3; BAZ2A; DNMT3L; JARID2B; EED; RBB4L; SMARCA5; TAF1B; DNMT1; H3F3B.1
Gene Expression
ZNF426; ZNF747; TRMT11; ZNF200; DNMT3B; ZNF549; VDRB; CSTF2; TYW3; ZFP1
Oxidative Stress Induced Senescence
BMI1A; EED; CBX6; CBX4; PHC2; PHC1; CBX8B; RNF2; KDM6B; BMI1B
PKMTs methylate histone lysines
SMYD3; RBBP5; DPY30; EHMT2; EED; SUZ12; AEBP2; SMYD2A; ASH2L; PRDM16

Protein Function

EED has several biochemical functions, for example, chromatin binding, histone methyltransferase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EED itself. We selected most functions EED had, and list some proteins which have the same functions with EED. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein FEZF2; EWSR1A; SREBF1; JUB; GLI1; PCGF2; HCFC1; ATF5; MEIS1; PRKCBB
Function histone methyltransferase activity
Related Protein PRMT2; EED; PRDM13; PRMT6; CARM1; SUV39H1; PRMT1; SUZ12; EZH2
Function identical protein binding
Related Protein BCL2L1; DPY30; SNX16; SQSTM1; E2F7; SERPINA1D; CEACAM5; CCDC91; BRI3; USP15
Function protein binding
Related Protein PIBF1; SEPT11; VPS45; GZMM; STRA13; AP3S1; ZNF202; RPS7; LRRC25; GTPBP3

Interacting Protein

EED has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EED here. Most of them are supplied by our site. Hope this information will be useful for your research of EED.
EZH2; DNMT3B; DNMT1; PINK1

EED Related Articles

Momen, SE; Jorizzo, J; et al. Erythema elevatum diutinum: a review of presentation and treatment. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 28:1594-1602(2014).
Andabaka, T; Nickerson, JW; et al. Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children. COCHRANE DATABASE OF SYSTEMATIC REVIEWS :-(2013).