EED
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Official Full Name
embryonic ectoderm development
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Overview
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
EED; embryonic ectoderm development; HEED; WAIT1; polycomb protein EED; WD protein associating with integrin cytoplasmic tails 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Others
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- EED Related Articles
EED involved in several pathways and played different roles in them. We selected most pathways EED participated on our site, such as Cellular Senescence, Cellular responses to stress, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EED were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cellular Senescence | HIST4H4;CDKN2B;CBX6;CBX8B;CBX6A;HMGA1;MAPKAPK2B;SUZ12;RBBP7 |
Cellular responses to stress | POT1A;NUP50;LAMTOR2;KIAA1967;MAP1LC3C;ULK1A;HIST1H1E;IGFBP7;PHC2 |
Chromatin modifying enzymes | KDM6AL;KAT8;ARID5B;RBBP5;COPRS;SUZ12;MBIP;SAP30;PADI3 |
Chromatin organization | KAT8;SMARCB1;KANSL3;SMARCC1;SMARCB1A;SMARCA4;SUZ12A;ING5A;SMARCB1B |
Epigenetic regulation of gene expression | RBB4L;SAP30L;SUDS3;TAF1C;EED;CD3EAP;H3F3B.1;TAF1B;SUZ12 |
Gene Expression | PRDX2;C14orf166;RRP8;NR1D2;SCO1;ZNF23;LAGE3;ZNF706;TPRKB |
Oxidative Stress Induced Senescence | CBX8A;SUZ12;CBX6A;EED;CBX8B;TNIK;SCMH1;PHC2;BMI1B |
PKMTs methylate histone lysines | SETD3;PRDM16;SUZ12B;EHMT2;SUZ12;ATF7IP;ASH2L;EED;SMYD2 |
EED has several biochemical functions, for example, chromatin binding, histone methyltransferase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EED itself. We selected most functions EED had, and list some proteins which have the same functions with EED. You can find most of the proteins on our site.
Function | Related Protein |
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chromatin binding | FABP1;HMGB2B;IFT74;MORF4L1;SVEP1;PKN1;HMGB3B;MPO;PATZ1 |
histone methyltransferase activity | SUV39H1;SUZ12;PRMT6;CARM1;PRMT2;EED;PRDM13;EZH2;PRMT1 |
identical protein binding | IK;CHMP4B;PYCARD;AMOTL2;GM5077;UBQLN4;CEACAM5;EIF2AK3;KCTD17 |
protein binding | CMTM5;SAV1;UNC119B;TSHR;NUPL1;CCS;NUDT4;ICAM3;ELMOD3 |
EED has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EED here. Most of them are supplied by our site. Hope this information will be useful for your research of EED.
EZH2; DNMT3B; DNMT1; PINK1
- Q&As
- Reviews
Q&As (7)
Ask a questionDysregulation of EED can lead to cancer, largely through epigenetic alterations and disrupted gene regulation.
EED helps maintain stem cell pluripotency and self-renewal capabilities, crucial for embryonic development.
EED works with PRC2 in chromatin remodeling, influencing gene silencing and cellular identity.
Changes in EED function impact developmental processes, potentially leading to congenital anomalies and disorders.
EED regulates gene expression by modulating histone methylation, affecting epigenetic landscapes.
EED is essential in embryonic stem cell development, guiding differentiation processes.
EED affects cellular aging and senescence, playing a role in age-related epigenetic changes.
Customer Reviews (3)
Write a reviewPrecise protein quantification, ensures data accuracy in our experiments.
Dependable peptide synthesis, accelerates our projects effectively.
Timely antibody validation, a valuable asset for our lab.
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