EFEMP2

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EFEMP2

Official Full Name EGF containing fibulin-like extracellular matrix protein 2
Background A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
Synonyms EFEMP2; EGF containing fibulin-like extracellular matrix protein 2; MBP1; UPH1; FBLN4; ARCL1B; EGF-containing fibulin-like extracellular matrix protein 2; FIBL-4; fibulin 4; fibulin-4; mutant p53 binding protein 1;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EFEMP2-229H Recombinant Human EFEMP2 Protein, His/GST-tagged E.coli His/GST
    Human EFEMP2-3086H Recombinant Human EFEMP2 Protein, GST-tagged Wheat Germ GST
    Human EFEMP2-52H Recombinant Human EFEMP2 protein, T7/His-tagged E.coli T7/His
    Human EFEMP2-6704HCL Recombinant Human EFEMP2 293 Cell Lysate HEK293 N/A
    Mouse Efemp2-233M Recombinant Mouse Efemp2 Protein, His-tagged E.coli His

    EFEMP2 involved in several pathways and played different roles in them. We selected most pathways EFEMP2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFEMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Elastic fibre formation MFAP2; LTBP4; FBN2; LOXL1; ABHD1; MFAP3; MFAP1B; FURINB; FURINA; LOXL4
    Extracellular matrix organization ASPN; COL9A1; CEACAM1; CTSK; MMP13; MMP12; TIMP2; MMP11; COL5A1; ADAM8A
    Molecules associated with elastic fibres MFAP1; LTBP2; EFEMP2; LTBP3; MFAP1B; MFAP3; EFEMP1; MFAP4; MFAP2; FBLN2

    EFEMP2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by EFEMP2 itself. We selected most functions EFEMP2 had, and list some proteins which have the same functions with EFEMP2. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding MMP19; RCN3; MMP11; PADI3; PCDH2G3; PCDHA2; MCTP2; PLA2G12A; EFCAB7; CAPN3B
    extracellular matrix structural constituent COL5A1; PXDN; FBLN2; PRELP; COL4A5; COL5A2; CD4; MUC5AC; FBN2B; OPTC
    protein binding CBLL1; RPSA; CNO; OSBPL1A; ITSN2; ZNF652; FAM164C; PPIE; TBP; VANGL1

    EFEMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFEMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFEMP2.

    SGTA; SGTB; ELN; FBN1; FBLN5; LOX

    Liu, Y; Wei, J; et al. Proteomic analysis of endothelial progenitor cells exposed to oxidative stress. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:607-614(2013).
    Kehrmann, A; Truong, H; et al. Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13. CANCER GENETICS 206:279-292(2013).

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