efemp2
Share
  • Official Full Name
  • EGF containing fibulin-like extracellular matrix protein 2
  • Background
  • A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
  • Synonyms
  • EFEMP2; EGF containing fibulin-like extracellular matrix protein 2; MBP1; UPH1; FBLN4; ARCL1B; EGF-containing fibulin-like extracellular matrix protein 2; FIBL-4; fibulin 4; fibulin-4; mutant p53 binding protein 1;
Cat.#:EFEMP2-229HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EFEMP2 Protein, His/GST-tagged
+Inquiry
Cat.#:EFEMP2-3086HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EFEMP2 Protein, GST-tagged
+Inquiry
Cat.#:Efemp2-233MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Efemp2 Protein, His-tagged
+Inquiry
Cat.#:EFEMP2-52HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EFEMP2 protein, T7/His-tagged
+Inquiry
Cat.#:EFEMP2-6704HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EFEMP2 293 Cell Lysate
+Inquiry

Involved Pathway

EFEMP2 involved in several pathways and played different roles in them. We selected most pathways EFEMP2 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFEMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Elastic fibre formation
LTBP3; MFAP3; ABHD1; FURINA; ITGB3A; MFAP5; LTBP2; LOXL3; EFEMP2; LOXL1
Extracellular matrix organization
MMP13; COL9A1; CTSD; LOXL3; FMOD; F11R.2; FURINA; ADAMTS1; MMP19; TIMP2
Molecules associated with elastic fibres
FBLN1; EFEMP1; LTBP2; LTBP3; LTBP4; BMP10; MFAP3; MFAP1; MFAP5; MFAP2

Protein Function

EFEMP2 has several biochemical functions, for example, calcium ion binding, extracellular matrix structural constituent, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFEMP2 itself. We selected most functions EFEMP2 had, and list some proteins which have the same functions with EFEMP2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein MATN2; PCDH2AB8; Npnt; RASGRP4; CALM2; ASPN; CDH24; CAPNS1; CALRL2; PCDH10A
Function extracellular matrix structural constituent
Related Protein IMPG2; COL5A3B; PRELP; LAMA1; TINAGL1; COL2A1B; COL11A2; FBLN1; ACAN; MATN1
Function protein binding
Related Protein MED4; CSF1; ARIH2; ARHGEF10; TNFAIP8L1; GATAD2A; STRA13; KAT2B; TWSG1; KIF4A

Interacting Protein

EFEMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFEMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFEMP2.
SGTA; SGTB; ELN; FBN1; FBLN5; LOX

EFEMP2 Related Articles

Liu, Y; Wei, J; et al. Proteomic analysis of endothelial progenitor cells exposed to oxidative stress. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:607-614(2013).
Kehrmann, A; Truong, H; et al. Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13. CANCER GENETICS 206:279-292(2013).