efna4
Share
  • Official Full Name
  • ephrin-A4
  • Background
  • This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.
  • Synonyms
  • EFNA4; ephrin-A4; EPLG4; LERK4; LERK-4; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4; EFL4; FLJ57652; MGC125826
Cat.#:EFNA4-323HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA4 Protein, His-tagged
+Inquiry
Cat.#:EFNA4-1380HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA4 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:Efna4-440MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ephrin A4
+Inquiry
Cat.#:EFNA4-151HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ephrin-A4
+Inquiry
Cat.#:EFNA4-1610HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Ephrin-A4
+Inquiry
Cat.#:EFNA4-177HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA4, Fc-tagged
+Inquiry
Cat.#:EFNA4-4336HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ephrin-A4, GST-Tagged
+Inquiry
Cat.#:Efna4-1130MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Efna4 protein, His & GST-tagged
+Inquiry
Cat.#:Efna4-4056MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efna4, Fc tagged
+Inquiry
Cat.#:Efna4-4057MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efna4, His tagged
+Inquiry
Cat.#:Efna4-1131RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Efna4 protein, His & T7-tagged
+Inquiry
Cat.#:Efna4-1132RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Efna4 protein, His & GST-tagged
+Inquiry
Cat.#:EFNA4-001HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA4 cell lysate
+Inquiry
Cat.#:EFNA4-2158MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EFNA4 cell lysate
+Inquiry

Involved Pathway

EFNA4 involved in several pathways and played different roles in them. We selected most pathways EFNA4 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
EPHA1; EPHA10; SEMA3C; PPP3CB; CSNK2A1; DUSP4; L1CAM; JAK3; TRPC3; CSF2RA
Developmental Biology
PTPRA; STX1B; RHOGA; RNF8; ITGB1B.1; SPTA1; WDR83; FGFR1B; FRS2B; CACNG8A
EPH-Ephrin signaling
MYL12B; ACTR2; EPHA10; EFNA2A; AP2A2; MYL12A; EFNA1; CLTB; EPHB3A; KALRNB
EPH-ephrin mediated repulsion of cells
EPHA10; EPHA2A; AP2A2; EPHA4A; EFNA3; EPHA2; EFNB3B; EFNB3; EPHB4A; EFNA1B
EPHA-mediated growth cone collapse
EFNA1; EFNA3; MYL12B; EFNA2A; EFNA1A; EFNA4; MYL9; EFNA3B; EFNA5; EPHA2A
PI3K-Akt signaling pathway
EFNA4; CSH2; CSF1R; EFNA2; LAMC3; CSH; CHAD; LOC608458; CSH1; CSF3R
Rap1 signaling pathway
EFNA2; RGS14; PFN4; LOC608458; EFNA4; CSF1
Ras signaling pathway
ABL1; MAPK3; ANGPT4; GNB1; PDGFA; PDGFRA; MRAS; FGF17; LAT; KLK1B4

Protein Function

EFNA4 has several biochemical functions, for example, ephrin receptor binding, protein binding, transmembrane-ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA4 itself. We selected most functions EFNA4 had, and list some proteins which have the same functions with EFNA4. You can find most of the proteins on our site.
Function
Related Protein
Function ephrin receptor binding
Related Protein CRK; EFNA4; EFNA1B; PTPN1; PIK3CG; NTRK3; EFNA2A; EFNB2; Anks1; GRB2
Function protein binding
Related Protein SUPT4H1; ASAP1; KRTAP5-9; PMM1; TRIM44; CACYBP; ITGB3BP; KRTAP19-5; RHOBTB3; TH1L
Function transmembrane-ephrin receptor activity
Related Protein EFNA3; EPHA1; EFNB3; EPHA10; EPHB2; EFNA4; EPHA4; EPHA5; EPHB1

Interacting Protein

EFNA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA4.
EPHA7