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Official Full Name egl-9 family hypoxia-inducible factor 3
Background Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism.
Synonyms EGLN3; egl-9 family hypoxia-inducible factor 3; PHD3; HIFPH3; HIFP4H3; egl nine homolog 3; HPH-1; HPH-3; HIF-PH3; HIF prolyl hydroxylase 3; HIF-prolyl hydroxylase 3; egl nine-like protein 3 isoform; hypoxia-inducible factor prolyl hydroxylase 3; prolyl hydroxylase domain-containing protein 3;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse EGLN3-1277M Recombinant Mouse EGLN3 Protein (2-239 aa), His-tagged E.coli His
    Human EGLN3-2544H Recombinant Human EGLN3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Egln3-499M Recombinant Mouse Egln3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human EGLN3-12327H Recombinant Human EGLN3, His-tagged E.coli His
    Human EGLN3-3119H Recombinant Human EGLN3 Protein, GST-tagged Wheat Germ GST
    Human EGLN3-400H Recombinant Human EGLN3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGLN3-6693HCL Recombinant Human EGLN3 293 Cell Lysate HEK293 N/A
    Human EGLN3-6851H Recombinant Human Egl Nine Homolog 3 (C. elegans), His-tagged E.coli His
    Mouse EGLN3-5051M Recombinant Mouse EGLN3 Protein Mammalian Cell His
    Rat EGLN3-2031R Recombinant Rat EGLN3 Protein Mammalian Cell His
    Rhesus Macaque EGLN3-1398R Recombinant Rhesus monkey EGLN3 Protein, His-tagged Mammalian Cell His
    Zebrafish EGLN3-12498Z Recombinant Zebrafish EGLN3 Mammalian Cell His

    EGLN3 involved in several pathways and played different roles in them. We selected most pathways EGLN3 participated on our site, such as Cellular response to hypoxia, Cellular responses to stress, HIF-1 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGLN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular response to hypoxia EGLN1B; EGLN3; HIF1AN; EGLN2; HIF1AL; HIF3A; EPAS1B
    Cellular responses to stress ATG4A; PTGES3; HIST1H1D; HIST1H1A; HDAC6; CEBPB; CDKN2C; DYNLL2A; HSPA14; AMBRA1
    HIF-1 signaling pathway CYBB; AHA-1; EGLN3; EGLN2
    HIF-1-alpha transcription factor network NDRG1; EGLN3; TFF3; CITED2; NPM1; GATA2; COPS5; ADM; ENG; CP
    HIF-2-alpha transcription factor network CITED2; EGLN3; HIF1AN; EGLN2
    Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha EGLN3; EGLN1B; HIF3A; EGLN2; EPAS1B; HIF1AL
    Pathways in cancer AKT1; PRKACG; AGTR1B; AKT2; FLT3LG; PLCB1; GNAI2; BMP2; FZD1; MMP1A
    Regulation of Hypoxia-inducible Factor (HIF) by oxygen EGLN2; EGLN1B; HIF3A; EPAS1B; HIF1AL; HIF1AN; EGLN3

    EGLN3 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by EGLN3 itself. We selected most functions EGLN3 had, and list some proteins which have the same functions with EGLN3. You can find most of the proteins on our site.

    Function Related Protein
    L-ascorbic acid binding PAM; PLOD1A; PHYH; LEPRE1; PLOD2; EGLN2; OGFOD1; P4HA1B; EGLN1; OGFOD3
    iron ion binding CYP46A1.1; FAM84B; KDM3A; TPH1B; HIF1AN; CYP2P6; SC5D; FTL; CYP2P7; ALOX15
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors C14orf169; JHDM1D; PHF8; KDM5BB; ALKBH8; EGLN1; KDM5C; ALKBH5; EGLN3; EGLN2
    peptidyl-proline 4-dioxygenase activity EGLN3; EGLN1; EGLN2
    protein binding KRTAP10-8; TACR2; SPATA2; BHLHE40; LRP4; B9D2; SMAD7; ANXA11; NEIL2; ASMTL

    EGLN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGLN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGLN3.


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