egr1
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  • Official Full Name
  • early growth response 1
  • Background
  • The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • EGR1; early growth response 1; TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268; early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A;
Cat.#:EGR1-3121HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EGR1 Protein, GST-tagged
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Cat.#:EGR1-28467THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EGR1
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Cat.#:EGR1-52Tag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGR1 protein, His-tagged
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Cat.#:EGR1-628HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGR1 Protein, His-tagged
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Cat.#:EGR1-5052MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EGR1 Protein
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Cat.#:Egr1-629MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Egr1 Protein, His-tagged
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Cat.#:EGR1-2032RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EGR1 Protein
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Cat.#:EGR1-1399RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EGR1 Protein, His-tagged
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Cat.#:EGR1-5712CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EGR1
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Cat.#:EGR1-8845ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EGR1
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Cat.#:EGR1-2120HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Early Growth Response 1
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Cat.#:EGR1-6692HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EGR1 293 Cell Lysate
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Involved Pathway

EGR1 involved in several pathways and played different roles in them. We selected most pathways EGR1 participated on our site, such as BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
EIF2S1; EIF4EBP1; CDKL5; DOK5; IGF2BP1; EGR2; YBX1; SIRPA; LINGO1; EGR1
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
DGKA; EGR1; EGR2; IRF4; JUNB; CTLA4; EGR3; POU2F1; EGR4; CDK4
Cytokine Signaling in Immune system
TRIM62; TNIP2; TRIM68; EIF4G1; UBE2V1; IFIT3; CNKSR1; TAB1; CSF2; NOD1
Downstream signaling in naive CD8+ T cells
EGR1; JUNB; EOMES; EGR4
ErbB1 downstream signaling
ACTR2; ACTR3; MAP3K2; CHN2; ABI1; ARF4; NCKAP1; EPS8; WASF2; BAIAP2
Glucocorticoid receptor regulatory network
KRT14; SMARCC2; BGLAP; EGR1; CSN2; SMARCD1; KRT17; KRT5; SMARCA4; NR1I3
HTLV-I infection
SMAD3; NFATC4; Il2; MAP2K4; GPS2; WNT3; FDPS; POLE4; HLA-DOB; POLE
Immune System
KIF3B; PRLRB; KLRB1A; LILRB5; UBE2J2; TRIM56; CD180; CD300LF; KLRG1; HAVCR2

Protein Function

EGR1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR1 itself. We selected most functions EGR1 had, and list some proteins which have the same functions with EGR1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein E2F5; PRIM2; UNCX; DMRTA2; SYCP3; LEF1; ILF3; PNN; FOXJ1A; SUB1B
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein SMYD3; SMAD5; MITF; GATA1; SPI1; ZFP335; GATA3; TCF7L2; GBX2; WBP2
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein CREB3L4; CREB3L3; EGR1; PHOX2A; GATA2; NR1I3; RARG; ZFP583; SKINT8; ZNF8
Function histone acetyltransferase binding
Related Protein CEBPB; EPAS1; SP1; TRIP4; TRP53; GLI3; EID1; ZBTB7A; CREB1; KAT2B
Function metal ion binding
Related Protein CNOT6L; ASAP3; SEC23IP; ATP9B; ALOX5A; PHF23B; ZSCAN5A; DNAJC21; TEC; ADAMTS16
Function protein binding
Related Protein DYNC1H1; OTX1; ZFP64; JAG1; TANK; CACNB4; PMF1; ARNTL1B; FAM72A; CD300LH
Function sequence-specific DNA binding
Related Protein PBX3B; HEY2; FEV; HOXC3A; ZFP161; GATA2A; EVX2; MEOX2; HMX4; HOXC4A
Function transcription factor activity, sequence-specific DNA binding
Related Protein RERE; THRB; SS18L1; ATF4; CTCF; RREB1; VAX2; ZNF92; CRX; NR6A1A
Function transcription factor binding
Related Protein RNF4; GATA3; CHCHD2; HDAC1; PPP1R13B; HOXA7; NKX3; APBB1; POU1F1; GCM1
Function transcription regulatory region sequence-specific DNA binding
Related Protein ZNF658; CRY2; SUV39H1; PSPC1; NFE2; SFPQ; MEF2CA; NFE2L3; PITX2; MKL1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HOXA5; E2F4; GLI2; CARF; TCF4; ELF4; JUN; SRF; GATA3; CREB3

Interacting Protein

EGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR1.
CDKN2A; CTNNB1; SNAI1; SP1; SUMO1; SREBF2; nos; astD; MAGEB2; MED6; DNAJC8

EGR1 Related Articles

Vogels, RJC; Vlenterie, M; et al. Solitary fibrous tumor - clinicopathologic, immunohistochemical and molecular analysis of 28 cases. DIAGNOSTIC PATHOLOGY 9:-(2014).
Prast, JM; Schardl, A; et al. Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8:-(2014).