EGR1
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Official Full Name
early growth response 1
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Overview
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008] -
Synonyms
EGR1; early growth response 1; TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268; early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
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- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- B2M
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- EGR1 Related Articles
- EGR1 Related Research Area
EGR1 involved in several pathways and played different roles in them. We selected most pathways EGR1 participated on our site, such as BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BDNF signaling pathway | GNB2L1;YBX1;FRS2;CFL1;FRS3;EEF2;CDK5;SIRPA;EIF2S1 |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | CSF2;JUNB;EGR4;EGR1;BATF3;CDK4;DGKA;IRF4;EGR2 |
| Cytokine Signaling in Immune system | RASGRP4;CSF2RB;TNIP2;PTPRA;EIF4A1;TRIM46;RASGEF1A;GBP5;DPF1 |
| Downstream signaling in naive CD8+ T cells | EOMES;EGR1;JUNB;EGR4 |
| ErbB1 downstream signaling | ACTR2;WASF2;ARF4;ACTR3;EPS8;BAIAP2;MAP3K2;CHN2;NCKAP1 |
| Glucocorticoid receptor regulatory network | POU2F1;SMARCC2;EGR1;KRT14;BGLAP;KRT5;KRT17;SMARCA4;CSN2 |
| HTLV-I infection | FOSL1;DVL3;HLA-DQB1;XIAP;RANBP3;TNFRSF13C;HLA-C;LTA;ANAPC5 |
| Immune System | AP1S1;PJA1;ATP6V1G3;BTR09;RAPGEF4;DDX41;PELI2;MKRN1;DZIP3 |
EGR1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR1 itself. We selected most functions EGR1 had, and list some proteins which have the same functions with EGR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ENG2A;RNF4;PROX1;HIST1H2AF;TRP53;FLI1A;POLA2;ZNF280D;PC |
| RNA polymerase II core promoter sequence-specific DNA binding | NSD1;NLRC5;RBPJ;TAL1;SOX11;GATA6;GATA3;SMAD1;H3F3B |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZFY1;ZNF79;ZFAT;SUV39H1;RXRB;FOXD3;RFX6;CSDA;MNT |
| histone acetyltransferase binding | PAX6;TAF7L;PCNA;NR4A3;TRP53;ETS1;TRIP4;SIRT2;KAT2B |
| metal ion binding | ERI3;UBA5;ANTXR2;LIMS2;ZNF573;NT5DC1;PDE11A;GFI1AB;ATF7B |
| protein binding | SFRP1;KIF5B;PHB;BTN3A1;TMED5;KRTAP10-5;POLE3;HYPK;PARP2 |
| sequence-specific DNA binding | SPI1A;FOXN3;PRDM5;BSX;LMX1A;FOXS1;MAFGB;ISX;RARGA |
| transcription factor activity, sequence-specific DNA binding | SLC12A9;FOXJ1A;RFX3;ELK4;E2F4;PIP4K2AA;DBPB;UHRF1;ZFP322A |
| transcription factor binding | C1QBP;PER1;CTBP1;CRY1;NCOR2;CSNK2B;DACT2;RPS3;ESRRB |
| transcription regulatory region sequence-specific DNA binding | SFPQ;POU5F1;NKX3;BTBD8;SOX4;EGR1;POU2F1;NR5A1;GATA3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOXK2;PGR;WT1;PAX8;CREB1;CEBPB;SIX1;FOXJ2;NR4A3 |
EGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR1.
CDKN2A; CTNNB1; SNAI1; SP1; SUMO1; SREBF2; nos; astD; MAGEB2; MED6; DNAJC8
- Q&As
- Reviews
Q&As (7)
Ask a questionTherapeutic strategies targeting EGR1 are being explored in cancer, neurological disorders, and cardiovascular diseases, aiming to modulate its activity for therapeutic benefit.
Dysregulation of EGR1 has been associated with various cancers, where it can function as either a tumor suppressor or oncogene depending on context.
EGR1 promotes cellular proliferation and plays a role in the initiation of cellular differentiation.
EGR1 functions as a transcription factor, regulating the expression of genes involved in cell growth, differentiation, and response to stimuli.
EGR1 is a critical component of the immediate-early response to cellular stress, aiding in the activation of genes required for survival and repair.
In the nervous system, EGR1 is involved in synaptic plasticity, contributing to learning and memory processes.
EGR1 expression is rapidly induced in response to a variety of external signals, including growth factors, stress, and hormonal stimuli.
Customer Reviews (3)
Write a reviewPerfect for cell assays.
Great in biochemical studies.
High quality, great performance.
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