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EIF2AK2

  • Official Full Name

    eukaryotic translation initiation factor 2-alpha kinase 2

  • Overview

    The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms

    EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF2AK2-31020TH Recombinant Human EIF2AK2 N/A
Human EIF2AK2-3148H Active Recombinant Human EIF2AK2 Protein, GST-tagged Insect Cell GST
Human EIF2AK2-298H Recombinant Human EIF2AK2, GST-tagged, Active Sf9 Insect Cell GST
Human EIF2AK2-563H Recombinant Human EIF2AK2 protein, His-tagged E.coli His Ser224~Ile502
Human EIF2AK2-332H Recombinant Human EIF2AK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EIF2AK2-3149H Recombinant Human EIF2AK2 Protein, GST-tagged Wheat Germ GST
Human EIF2AK2-12350H Recombinant Human EIF2AK2, His-tagged E.coli His 1-373a.a.
Human EIF2AK2-6674HCL Recombinant Human EIF2AK2 293 Cell Lysate HEK293 N/A
Human EIF2AK2-818H-B Recombinant Human EIF2AK2 Protein Pre-coupled Magnetic Beads HEK293
Human EIF2AK2-1385H Recombinant Human EIF2AK2 Protein (2-551 aa), His-tagged Yeast His 2-551 aa
Human EIF2AK2-2163H Recombinant Human EIF2AK2 Protein (Ser224-Ile502), N-His tagged E.coli N-His Ser224-Ile502
Human EIF2AK2-473H Recombinant Human EIF2AK2 Protein (2-551 aa), His-SUMO-tagged E.coli His/SUMO 2-551 aa
Human EIF2AK2-2983H Recombinant Human EIF2AK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF2AK2-153HFL Recombinant Full Length Human EIF2AK2 Protein, C-Flag-tagged Mammalian cells Flag
Human EIF2AK2-818H Recombinant Human EIF2AK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EIF2AK2-5076M Recombinant Mouse EIF2AK2 Protein Mammalian Cell His
Mouse EIF2AK2-489M Recombinant Mouse Eif2ak2 protein, GST-tagged Insect Cell GST
Mouse Eif2ak2-2727M Recombinant Mouse Eif2ak2 protein, His & T7-tagged E.coli His/T7 Asn205~Glu495 (Accession # Q03963)
Mouse Eif2ak2-2771M Recombinant Mouse Eif2ak2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse EIF2AK2-2699M-B Recombinant Mouse EIF2AK2 Protein Pre-coupled Magnetic Beads HEK293
Mouse EIF2AK2-2699M Recombinant Mouse EIF2AK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF2AK2-2044R Recombinant Rat EIF2AK2 Protein Mammalian Cell His
Rat Eif2ak2-2728R Recombinant Rat Eif2ak2 protein, His & T7-tagged E.coli His/T7 Gln279~Glu506 (Accession # Q63184)
Rat EIF2AK2-1701R-B Recombinant Rat EIF2AK2 Protein Pre-coupled Magnetic Beads HEK293
Rat EIF2AK2-1701R Recombinant Rat EIF2AK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EIF2AK2-1414R Recombinant Rhesus monkey EIF2AK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EIF2AK2-1238R Recombinant Rhesus Macaque EIF2AK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EIF2AK2-1238R-B Recombinant Rhesus Macaque EIF2AK2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish EIF2AK2-6421Z Recombinant Zebrafish EIF2AK2 Mammalian Cell His
Chicken EIF2AK2-6057C Recombinant Chicken EIF2AK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF2AK2 Related Research Area

EIF2AK2 involved in several pathways and played different roles in them. We selected most pathways EIF2AK2 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumEDEM1;ATF6;MAPK8B;NPLOC4;ERN1;CAPN1A;MAPK9;DNAJC5AA;HYOU1
Hepatitis CNFKB1;MAPK10;CLDN9;TRAF6;BRAF;PIK3R1;CLDN17;ARAF;IFNA4
MeaslesIFNAR2;OAS2;EIF2AK3;HSPA1L;MX1;PIK3R1;IL13;IFNA5;TNFAIP3
Influenza ACPSF4;IL8L2;IFNA10;MAP2K1;MAP2K7;PABPN1;BMA2;IL6;HSPA8
Herpes simplex infectionHLA-DMB;IFNB;TAF9B;MAPK8A;CUL1A;SKP1;TBPL2;PTPN11B;CDC34A
Epstein-Barr virus infectionPIK3R2;PSMD12;MAPK8;PSMD8;NFKBIA;POLR3K;HSPA2;NCOR2;MAPK9
Viral carcinogenesisHIST1H4K;HIST2H2BB;HLA-E;TBP;HIST1H2BB;HLA-C;ACTN3;SCIN;HIST3H2BB-PS

EIF2AK2 has several biochemical functions, for example, ATP binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK2 itself. We selected most functions EIF2AK2 had, and list some proteins which have the same functions with EIF2AK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingLONP1;ACTR2A;SPG7;SRPK1;ALPK1;PRKX;SMC4;C10orf2;SUCLA2
double-stranded RNA bindingEIF2C3;TFRC;IFIH1;LRRFIP1;TLR8;ZFP346;HSPD1;HSP90AB1;AGO1
eukaryotic translation initiation factor 2alpha kinase activityEIF2AK3;EIF2AK4;EIF2AK2;ALPK2;EIF2AK1
non-membrane spanning protein tyrosine kinase activityFYNB;PTK2BB;FYN;Fert2;LYN;PRKCD;MATK;PTK6B;WEE1
poly(A) RNA bindingPPHLN1;VCP;UCHL5;HMGN2;SART1;NAT10;ATP5A1;DYNC1H1;ELAC2
protein bindingUSP47;TMED5;TSHR;TMEM190;INS;NR1H2;GNPDA2;STIP1;HIP1R
protein kinase activityLMTK3;BRAF;CDK11A;TESK2;SBK3;JAK2A;CHEK1;TNIKB;PANK1A
protein phosphatase type 2A regulator activityPPP2R5E;EIF2AK2;ENSAA;ARPP19;PPP2R5A;PPP2R2B;PPP2R5EA;PPP2R5CB;PPP2R5C
protein serine/threonine kinase activitySLC14A2;STK31;CSNK1G2B;SQSTM1;PAK7;ACVR1;MAP3K2;DCAMKL2;CLK1

EIF2AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK2.

EIF2S1; p27958-pro_0000037576; p27958-pro_0000037570; N/A; DHX30; US11

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How does EIF2AK2 relate to apoptosis? 04/17/2022

EIF2AK2 can be involved in the regulation of apoptosis by triggering the apoptotic process by inducing eIF2α phosphorylation.

Are there other coding variants in the EIF2AK gene? 02/24/2021

Yes, in addition to the primary EIF2AK gene, there are other coding variants that may have different functions and expression patterns.

How is EIF2AK2 related to the development of tumors? 10/18/2020

Studies have shown that EIF2AK2 abnormal expression levels in some tumors may be related to the occurrence and progression of tumors.

What are the possible causes of abnormal EIF2AK2 expression levels? 09/08/2020

Abnormal EIF2AK2 expression levels may be due to genetic mutations, chromosomal abnormalities, environmental factors, etc.

How does EIF2AK2 have to do with viral infection? 05/05/2020

Studies have shown that EIF2AK2 can participate in the regulation of antiviral immune responses and affect the course of viral infections.

What are the applications of EIF2AK2 in drug discovery? 12/28/2019

EIF2AK2 can be used as a target for the development of new drugs, especially in the areas of neurodegenerative diseases and autoimmune diseases.

Customer Reviews (3)

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Reviews
03/05/2022

    EIF2AK2 has a low immunogenicity and does not cause an abnormal immune response.

    01/02/2022

      Remarkable progress has been made in the application of EIF2AK2 in related fields.

      06/14/2021

        The activity of EIF2AK2 is similar to that of natural proteins and is able to perform its intended biological function.

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