eif2ak2
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  • Official Full Name
  • eukaryotic translation initiation factor 2-alpha kinase 2
  • Background
  • The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms
  • EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent;
Cat.#:EIF2AK2-1385HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human EIF2AK2 Protein (2-551 aa), His-tagged
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Cat.#:EIF2AK2-473HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2AK2 Protein (2-551 aa), His-SUMO-tagged
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Cat.#:EIF2AK2-3148HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EIF2AK2 Protein, GST-tagged
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Cat.#:EIF2AK2-3149HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF2AK2 Protein, GST-tagged
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Cat.#:EIF2AK2-332HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EIF2AK2 Protein, MYC/DDK-tagged
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Cat.#:EIF2AK2-298HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EIF2AK2, GST-tagged, Active
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Cat.#:EIF2AK2-12350HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2AK2, His-tagged
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Cat.#:EIF2AK2-31020THTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF2AK2
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Cat.#:EIF2AK2-563HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2AK2 protein, His-tagged
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Cat.#:Eif2ak2-2727MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Eif2ak2 protein, His & T7-tagged
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Cat.#:EIF2AK2-489MTag:GST
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Eif2ak2 protein, GST-tagged
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Cat.#:EIF2AK2-5076MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF2AK2 Protein
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Cat.#:EIF2AK2-2044RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF2AK2 Protein
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Cat.#:Eif2ak2-2728RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Eif2ak2 protein, His & T7-tagged
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Cat.#:EIF2AK2-1414RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EIF2AK2 Protein, His-tagged
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Cat.#:EIF2AK2-6057CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EIF2AK2
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Cat.#:EIF2AK2-6421ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF2AK2
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Cat.#:EIF2AK2-6674HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF2AK2 293 Cell Lysate
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Involved Pathway

EIF2AK2 involved in several pathways and played different roles in them. We selected most pathways EIF2AK2 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
BAX; ATF4; HSC70; STT3B; EDEM1; DNAJC1; UBE2E1; HSP90B1; UGGT2; UBE2D4
Hepatitis C
IFNA5; RXRA; IRF1; IFNA6; PIK3CA; IFNA8; PIK3CB; EIF3E; TNF; CLDN6
Measles
EIF3H; MAP3K7; TRP53; PIK3CD; IFIH1; HSPA8; CCND1; CD3E; CD3D; IFNA13; EIF2AK4
Influenza A
TMPRSS13; IKBKE; PIK3CB; HSPA6; MAVS; MAPK10; IL8L2; HSPA1B; CXCL10; ACTB
Herpes simplex infection
FADD; PPP1CC; MHC2DEB; IFNB; IFN-a; IFNA6; SFRS3B; SRSF7B; TLR2; FAS
Epstein-Barr virus infection
TRADD; EIF2AK3; POLR3H; PIK3R3; RBPJL; CD19; CR2; CCNA2; RBPJ; MAPK8
Viral carcinogenesis
GTF2H3; GTF2A1L; H2BFWT; IL6ST; HPN; HIST1H2BL; RBL1; GTF2H2; HLA-F; PIK3CB

Protein Function

EIF2AK2 has several biochemical functions, for example, ATP binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK2 itself. We selected most functions EIF2AK2 had, and list some proteins which have the same functions with EIF2AK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MSH3; TTLL3; DDX43; LATS2; SMARCA2; PFKMB; KCNJ8; NAT10; GTF2F2B; IKBKB
Function double-stranded RNA binding
Related Protein MSN; TARBP2; ELAVL1; SLC3A2; IFIH1; DROSHA; HSPD1; HSP90AB1; SUPV3L1; TLR8
Function eukaryotic translation initiation factor 2alpha kinase activity
Related Protein ALPK2; EIF2AK1; EIF2AK4; EIF2AK2; EIF2AK3
Function non-membrane spanning protein tyrosine kinase activity
Related Protein STK16; BLK; YES1; TNK1; MATK; MELK; STYK1; LCK; TYK2; ZNF143B
Function poly(A) RNA binding
Related Protein SNRPD3; HARS2; RPL30; RBM19; HADHB; POLR2B; METAP2; RRP12; FAM98B; RP9
Function protein binding
Related Protein MTA2; FUT11; CAPNS2; CD86; ZEB1; EVLA; GTF2H1; AAAS; HADHB; PARK7
Function protein kinase activity
Related Protein BMPR1AA; SRC; NPR2; STK30; PHKG1B; BMPR1BA; CDKL3; GRK7B; RPS6KA5; PTK7A
Function protein phosphatase type 2A regulator activity
Related Protein PPP2R5B; SET; PPP2R5EB; PPP2R5CB; ENSA; PPP2R1A; PPP2R2B; PPP2R2A; PPP2R2CA; ENSAA
Function protein serine/threonine kinase activity
Related Protein MAP3K12; MAPKAPK2; SGK2; PDPK1; ILK; PAK1; RAF1; BCR; TAOK1; TGFBR1

Interacting Protein

EIF2AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK2.
EIF2S1; p27958-pro_0000037576; p27958-pro_0000037570; N/A; DHX30; US11