eif2ak2
Share
  • Official Full Name
  • eukaryotic translation initiation factor 2-alpha kinase 2
  • Background
  • The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms
  • EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent;
Cat.#:EIF2AK2-3148HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EIF2AK2 Protein, GST-tagged
+Inquiry
Cat.#:EIF2AK2-3149HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF2AK2 Protein, GST-tagged
+Inquiry
Cat.#:EIF2AK2-332HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EIF2AK2 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:EIF2AK2-298HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EIF2AK2, GST-tagged, Active
+Inquiry
Cat.#:EIF2AK2-12350HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2AK2, His-tagged
+Inquiry
Cat.#:EIF2AK2-31020THTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF2AK2
+Inquiry
Cat.#:EIF2AK2-563HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2AK2 protein, His-tagged
+Inquiry
Cat.#:Eif2ak2-2727MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Eif2ak2 protein, His & T7-tagged
+Inquiry
Cat.#:EIF2AK2-489MTag:GST
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Eif2ak2 protein, GST-tagged
+Inquiry
Cat.#:EIF2AK2-5076MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF2AK2 Protein
+Inquiry
Cat.#:EIF2AK2-2044RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF2AK2 Protein
+Inquiry
Cat.#:Eif2ak2-2728RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Eif2ak2 protein, His & T7-tagged
+Inquiry
Cat.#:EIF2AK2-1414RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EIF2AK2 Protein, His-tagged
+Inquiry
Cat.#:EIF2AK2-6057CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EIF2AK2
+Inquiry
Cat.#:EIF2AK2-6421ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF2AK2
+Inquiry
Cat.#:EIF2AK2-6674HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF2AK2 293 Cell Lysate
+Inquiry

Involved Pathway

EIF2AK2 involved in several pathways and played different roles in them. We selected most pathways EIF2AK2 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
MAPK8; CAPN2; RAD23AA; UBE2G2; FBXO2; RRBP1B; HNF4B; PKZ; HSC70; DNAJB1B
Hepatitis C
CLDN3; CLDN15; OAS1B; MAPK3; BRAF; MAPK11; IFNA2; EIF3E; BAD; GRB2
Measles
EIF2AK4; TNFAIP3; NFKBIA; TP53; IFNA16; FCGR2B; CCND3; PIK3R5; IRF7; Il2
Influenza A
IL-8; DDX39B; MAPK3; MAPK9; HSPA2; MAPK1; NFKB1; NLRX1; TBK1; PIK3R3
Herpes simplex infection
HLA-DPA1; TAF6L; HLA-DMB; BF1; C5; NFKBIA; IL12B; TTC6; HNRNPK; H2-Q10
Epstein-Barr virus infection
NFKBIB; POLR2C; MAPK8; IKBKG; AKAP8L; H2-Q10; SFPI1; PIK3CB; CD58; POLR2J2
Viral carcinogenesis
HLA-E; RELA; POLB; TRAF1; TBP; PIK3R5; C3; RBL2; CREB3L3; HIST1H4M

Protein Function

EIF2AK2 has several biochemical functions, for example, ATP binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK2 itself. We selected most functions EIF2AK2 had, and list some proteins which have the same functions with EIF2AK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TAOK1; ATAD3A; STRADB; ABCB6; SMOK2B; CAMK1DA; KATNAL1; MAP4K4; LMTK3; ORC4
Function double-stranded RNA binding
Related Protein OASL; OAS3; LRRFIP1; MSN; PRKRIP1; MTDH; VIM; DICER1; AGO2; HMGB1
Function eukaryotic translation initiation factor 2alpha kinase activity
Related Protein EIF2AK4; EIF2AK2; EIF2AK1; EIF2AK3; ALPK2
Function non-membrane spanning protein tyrosine kinase activity
Related Protein FGR; PTK6B; FER; PTK6; FES; Fert2; FRK; PTK2; FYNA; RIPK2
Function poly(A) RNA binding
Related Protein FXR2; C1orf35; MDH2; RPL30; DHX8; MEX3B; SNRNP70; NOC3L; DIMT1L; ZCCHC24
Function protein binding
Related Protein GLRB; CEP76; USP4; REEP1; C4orf33; TMEM30A; F3; MT2A; LRRC29; SYTL4
Function protein kinase activity
Related Protein TRIM28; KALRN; MAK; CAMK1DA; PLK5; PDPK1B; SRPK1B; ARAF; SCYL2; CDK9
Function protein phosphatase type 2A regulator activity
Related Protein pab1; PPP2R1B; PPP2R3A; ENSA; PPP2R5D; PPP2R4; EIF2AK2; PPP2R5A; IGBP1; PPP2R5E
Function protein serine/threonine kinase activity
Related Protein SPEG; SRPK1B; MAP4K1; PIM2; MAP2K2; NEK11; STK16; ACVRL1; PRKCI; OXSR1B

Interacting Protein

EIF2AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK2.
EIF2S1; p27958-pro_0000037576; p27958-pro_0000037570; N/A; DHX30; US11