EIF2AK4 Protein, eukaryotic translation initiation factor 2 alpha kinase 4

EIF2AK4

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EIF2AK4

Official Full Name eukaryotic translation initiation factor 2 alpha kinase 4
Background EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation;factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et;al., 1999 (PubMed 10504407)).
Synonyms EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; KIAA1338; GCN2-like protein; GCN2 eIF2alpha kinase
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2AK4-1011H Recombinant Human Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4, GST-tagged Sf9 Insect Cell GST
    Human EIF2AK4-28160TH Recombinant Human EIF2AK4 Wheat Germ N/A
    Human EIF2AK4-3152H Recombinant Human EIF2AK4 Protein, GST-tagged Insect Cell GST
    Human EIF2AK4-3153H Recombinant Human EIF2AK4 Protein, GST-tagged Wheat Germ GST
    Human EIF2AK4-6672HCL Recombinant Human EIF2AK4 293 Cell Lysate HEK293 N/A
    Mouse EIF2AK4-5078M Recombinant Mouse EIF2AK4 Protein Mammalian Cell His

    EIF2AK4 involved in several pathways and played different roles in them. We selected most pathways EIF2AK4 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum DNAJC1; NFE2L2; PPP1R15A; CALR3B; CKAP4; MAPK8B; SYVN1; BCL2; SSR4; UBE4B
    Hepatitis C Ifna15; SOS1; IFNAR2; TBK1; CLDN17; IL-8; CLDN6; IFNA7; IRF1; IFNA6
    Measles CBLB; IFNA2; Il2; IL12A; IL1B; MSN; PIK3CB; IRAK1; NFKBIA; IFNAR2
    Influenza A HSPA2; MAPK9; MAPK10; HSPA6; HLA-DQA1; HSPA1B; CCL5; HLA-DPB1; STAT2; DDX58
    Herpes simplex infection PER1; JAK2B; HLA-DPA1; IFNA6; IFNB; BLB1; IFNA14; TNF; TRAF5; TBPL2
    Epstein-Barr virus infection NUP214; ICAM1; PSMC4; MAPK12; PSMC3; FCER2; PRKACG; PSMC6; HLA-F; TRAF1

    EIF2AK4 has several biochemical functions, for example, ATP binding, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK4 itself. We selected most functions EIF2AK4 had, and list some proteins which have the same functions with EIF2AK4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PTK2BB; IRAK3; SYN1; P2RX3B; CHD1; IARS; ABCB1A; DDX10; ROR1; ACTR1B
    eukaryotic translation initiation factor 2alpha kinase activity EIF2AK1; ALPK2; EIF2AK4; EIF2AK3; EIF2AK2
    protein serine/threonine kinase activity ILK; NIM1; GRK5; NEK8; TTBK1; ADCK5; IRAK4; CDK14; RPS6KA3; ULK1A
    tRNA binding TERT; TRMT11; TRMT1L; NSUN2; PTCD1; EIF2A; EIF2AK4; AIMP1; METTL1; TRNT1

    EIF2AK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK4.

    a8k1f4_human; b4dyc6_human; BAG2; STIP1; MLF1; USP46; PSMD2; CDC37; q53fc7_human; HSP90AB1; NUDCD3; q96be0_human; AARSD1; CACYBP; EWSR1; linkable pd173955 analogue; bosutinib; imatinib; ARRB2

    Querec, TD; Akondy, RS; et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. NATURE IMMUNOLOGY 10:116-125(2009).
    Skalnikova, H; Vodicka, P; et al. Protein signaling pathways in differentiation of neural stem cells. PROTEOMICS 8:4547-4559(2008).

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