|Official Full Name||eukaryotic translation initiation factor 2 alpha kinase 4|
|Background||EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation;factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et;al., 1999 (PubMed 10504407)).|
|Synonyms||EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; KIAA1338; GCN2-like protein; GCN2 eIF2alpha kinase|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
EIF2AK4 involved in several pathways and played different roles in them. We selected most pathways EIF2AK4 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Protein processing in endoplasmic reticulum||DNAJC1; NFE2L2; PPP1R15A; CALR3B; CKAP4; MAPK8B; SYVN1; BCL2; SSR4; UBE4B|
|Hepatitis C||Ifna15; SOS1; IFNAR2; TBK1; CLDN17; IL-8; CLDN6; IFNA7; IRF1; IFNA6|
|Measles||CBLB; IFNA2; Il2; IL12A; IL1B; MSN; PIK3CB; IRAK1; NFKBIA; IFNAR2|
|Influenza A||HSPA2; MAPK9; MAPK10; HSPA6; HLA-DQA1; HSPA1B; CCL5; HLA-DPB1; STAT2; DDX58|
|Herpes simplex infection||PER1; JAK2B; HLA-DPA1; IFNA6; IFNB; BLB1; IFNA14; TNF; TRAF5; TBPL2|
|Epstein-Barr virus infection||NUP214; ICAM1; PSMC4; MAPK12; PSMC3; FCER2; PRKACG; PSMC6; HLA-F; TRAF1|
EIF2AK4 has several biochemical functions, for example, ATP binding, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK4 itself. We selected most functions EIF2AK4 had, and list some proteins which have the same functions with EIF2AK4. You can find most of the proteins on our site.
|ATP binding||PTK2BB; IRAK3; SYN1; P2RX3B; CHD1; IARS; ABCB1A; DDX10; ROR1; ACTR1B|
|eukaryotic translation initiation factor 2alpha kinase activity||EIF2AK1; ALPK2; EIF2AK4; EIF2AK3; EIF2AK2|
|protein serine/threonine kinase activity||ILK; NIM1; GRK5; NEK8; TTBK1; ADCK5; IRAK4; CDK14; RPS6KA3; ULK1A|
|tRNA binding||TERT; TRMT11; TRMT1L; NSUN2; PTCD1; EIF2A; EIF2AK4; AIMP1; METTL1; TRNT1|
EIF2AK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK4.
a8k1f4_human; b4dyc6_human; BAG2; STIP1; MLF1; USP46; PSMD2; CDC37; q53fc7_human; HSP90AB1; NUDCD3; q96be0_human; AARSD1; CACYBP; EWSR1; linkable pd173955 analogue; bosutinib; imatinib; ARRB2