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EIF2AK4

  • Official Full Name

    eukaryotic translation initiation factor 2 alpha kinase 4

  • Overview

    EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation;factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et;al., 1999 (PubMed 10504407)).
  • Synonyms

    EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; KIAA1338; GCN2-like protein; GCN2 eIF2alpha kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF2AK4-28160TH Recombinant Human EIF2AK4 Wheat Germ N/A 100 amino acids
Human EIF2AK4-3153H Recombinant Human EIF2AK4 Protein, GST-tagged Wheat Germ GST
Human EIF2AK4-1011H Recombinant Human Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4, GST-tagged Sf9 Insect Cell GST
Human EIF2AK4-3152H Active Recombinant Human EIF2AK4 Protein, GST-tagged Insect Cell GST
Human EIF2AK4-6672HCL Recombinant Human EIF2AK4 293 Cell Lysate HEK293 N/A
Human EIF2AK4-3747HF Active Recombinant Full Length Human EIF2AK4 Protein, GST-tagged Insect (sf21) GST 1-1649(end)
Human EIF2AK4-3346H Recombinant Human EIF2AK4 protein, His-tagged E.coli His
Human EIF2AK4-1414H Recombinant Human EIF2AK4 Protein, His-tagged E.coli N-His Val296-Ile539
Human EIF2AK4-2310HF Active Recombinant Full Length Human EIF2AK4 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1649(end)
Human EIF2AK4-4488HF Recombinant Full Length Human EIF2AK4 Protein, GST-tagged In Vitro Cell Free System GST 91 amino acids
Mouse EIF2AK4-5078M Recombinant Mouse EIF2AK4 Protein Mammalian Cell His
Mouse EIF2AK4-2700M-B Recombinant Mouse EIF2AK4 Protein Pre-coupled Magnetic Beads HEK293
Mouse EIF2AK4-2700M Recombinant Mouse EIF2AK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF2AK4 Related Articles

EIF2AK4 involved in several pathways and played different roles in them. We selected most pathways EIF2AK4 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumCALR;HYOU1;AMFR;UBQLN2;STT3B;MAPK8B;NFE2L2A;DNAJC5B;UBE2E1
Hepatitis CPIK3CG;EIF3E;TBK1;OAS1A;STAT1;IFNA12;IKBKG;MAPK9;RAF1
MeaslesOAS1;CLEC4M;IFNA13;TNFAIP3;TYK2;TRP53;IFNA6;OAS1A;HSPA1L
Influenza AEIF2AK1;IFNA12;RNASEL;IFNB1;H2-AA;BLB1;HSPA1A;IFNG;ADAR
Herpes simplex infectionABCB3L1;MHC1UEA;CSNK2A2;PER1B;MHC2DCB;ARNTL;HCFC1A;HLA-C;HNRNPK
Epstein-Barr virus infectionNEDD4;POLR3B;ITGAL;IRF3;NFKBIE;TRP53;PIK3CA;HLA-DQA2;HLA-DPB1

EIF2AK4 has several biochemical functions, for example, ATP binding, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK4 itself. We selected most functions EIF2AK4 had, and list some proteins which have the same functions with EIF2AK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRUNX3;RHOBTB3;UBE2D3;GRK7;RBKS;DMPK;ACSM5;RIOK3;MAPK8
eukaryotic translation initiation factor 2alpha kinase activityEIF2AK3;EIF2AK2;EIF2AK4;EIF2AK1;ALPK2
protein serine/threonine kinase activityBCKDK;PKN1B;PRPF4B;MAST2;ADCK4;EIF2AK2;PINK1;AKT1;BMPR1BB
tRNA bindingYARS2;RPL35A;DARS2;AARSD1;FARSA;IGHMBP2;FDXACB1;TERT;SEPSECS

EIF2AK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK4.

a8k1f4_human; b4dyc6_human; BAG2; STIP1; MLF1; USP46; PSMD2; CDC37; q53fc7_human; HSP90AB1; NUDCD3; q96be0_human; AARSD1; CACYBP; EWSR1; linkable pd173955 analogue; bosutinib; imatinib; ARRB2

Querec, TD; Akondy, RS; et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. NATURE IMMUNOLOGY 10:116-125(2009).
Skalnikova, H; Vodicka, P; et al. Protein signaling pathways in differentiation of neural stem cells. PROTEOMICS 8:4547-4559(2008).
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