Human EIF2AK4 Knockdown Cell Lysate

• Cat.No.: EIF2AK4-342HKCL
• Product Overview: WB-validated EIF2AK4 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 187 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg EIF2AK4 KD HeLa cell lysate
• Protein Families: Druggable Genome, Protein Kinase
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 [ Homo sapiens (human) ]
• Official Symbol: EIF2AK4
• Synonyms: EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; KIAA1338; GCN2-like protein; GCN2 eIF2alpha kinase
• Gene ID: 440275
• mRNA Refseq: NM_001013703
• Protein Refseq: NP_001013725
• MIM: 609280
• UniProt ID: Q9P2K8