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EIF2B3

  • Official Full Name

    eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa

  • Overview

    The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Synonyms

    EIF2B3; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; EIF-2B; EIF2Bgamma; translation initiation factor eIF-2B subunit gamma; eIF-2B GDP-GTP exchange factor subunit gamma;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF2B3-3157H Recombinant Human EIF2B3 Protein, GST-tagged Wheat Germ GST
Human EIF2B3-12355H Recombinant Human EIF2B3, GST-tagged E.coli GST C-term-218a.a.
Human EIF2B3-333H Recombinant Human EIF2B3 Protein, His-tagged E.coli His
Human EIF2B3-28491TH Recombinant Human EIF2B3, His-tagged E.coli His
Human EIF2B3-327H Recombinant Human EIF2B3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EIF2B3-6671HCL Recombinant Human EIF2B3 293 Cell Lysate HEK293 N/A
Human EIF2B3-4557H Recombinant Human EIF2B3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF2B3-4491HF Recombinant Full Length Human EIF2B3 Protein, GST-tagged In Vitro Cell Free System GST 452 amino acids
Human EIF2B3-3153H Recombinant Human EIF2B3 protein, His-tagged E.coli His 15-232 aa
Mouse Eif2b3-357M Recombinant Mouse Eif2b3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat EIF2B3-2047R Recombinant Rat EIF2B3 Protein Mammalian Cell His
Rat EIF2B3-1704R-B Recombinant Rat EIF2B3 Protein Pre-coupled Magnetic Beads HEK293
Rat EIF2B3-1704R Recombinant Rat EIF2B3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EIF2B3-1416R Recombinant Rhesus monkey EIF2B3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EIF2B3-1240R-B Recombinant Rhesus Macaque EIF2B3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EIF2B3-1240R Recombinant Rhesus Macaque EIF2B3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish EIF2B3-11300Z Recombinant Zebrafish EIF2B3 Mammalian Cell His
Chicken EIF2B3-2937C Recombinant Chicken EIF2B3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF2B3 Related Articles

EIF2B3 involved in several pathways and played different roles in them. We selected most pathways EIF2B3 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA transportXPOT;THOC2;EIF2S3Y;STRAP;THOC6;SMN;EIF3B;EIF3G;EIF4BA

EIF2B3 has several biochemical functions, for example, NOT S-methyl-5-thioribose-1-phosphate isomerase activity, contributes_to guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B3 itself. We selected most functions EIF2B3 had, and list some proteins which have the same functions with EIF2B3. You can find most of the proteins on our site.

Function Related Protein
NOT S-methyl-5-thioribose-1-phosphate isomerase activityEIF2B1;EIF2B2;EIF2B4;EIF2B3
contributes_to guanyl-nucleotide exchange factor activityALS2;LAMTOR3;EIF2B5;C7orf59;EIF2B1;LAMTOR2;EIF2B2;EIF2B4;HBXIP
protein bindingOCRL;FAM9A;ARL13B;CETN2;PTPRB;TOM1;MAP2K4;FBXL12;RORA
contributes_to translation initiation factor activityEIF3J;EIF3F;EIF3B;EIF3A;EIF2B3;EIF2B1;EIF2B2;EIF2B4;EIF3G
translation initiation factor bindingEIF2B5;ZFP259;EIF3F;EIF2B3;POLR2GL;EIF3BA;LARP1;CELF1;EIF2B4

EIF2B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B3.

EIF2B1; STC2; NDUFB8; GOLM1; pi3p; ZWINT; EGFR; Cdk1; NSS; CDC42

Robinson, ME; Rossignol, E; et al. Vanishing White Matter Disease in French-Canadian Patients From Quebec. PEDIATRIC NEUROLOGY 51:225-232(2014).
Wan, JY; Edwards, KL; et al. Association mapping of the PARK10 region for Parkinson's disease susceptibility genes. PARKINSONISM & RELATED DISORDERS 20:93-98(2014).
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