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EIF6

  • Official Full Name

    eukaryotic translation initiation factor 6

  • Overview

    Eukaryotic initiation factor 6 (eIF6) is reqiured for the 60S ribosomal subunit assembly in the nucleolus. In the cytoplasm, this protein is bound to 60S ribosome subunits and prevents them from joining 40S ribosome subunits to form 80S ribosomes. eIF6 is
  • Synonyms

    EIF6; eukaryotic translation initiation factor 6; EIF3A, integrin beta 4 binding protein , ITGB4BP; b(2)gcn; p27BBP; B4 integrin interactor; p27 beta-4 integrin-binding protein; eukaryotic translation initiation factor 3A; CAB; EIF3A; eIF-6; ITGB4BP; p27;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF6-2911H Recombinant Human Eukaryotic Translation Initiation Factor 6, T7-tagged E.coli T7
Human EIF6-26861TH Recombinant Human EIF6 Wheat Germ N/A 100 amino acids
Human EIF6-141H Recombinant Human EIF6 protein, T7-tagged E.coli T7
Human EIF6-12391H Recombinant Human EIF6 protein, GST-tagged E.coli GST 1-245 aa
Human EIF6-3218H Recombinant Human EIF6 Protein, GST-tagged Wheat Germ GST
Human EIF6-245HCL Recombinant Human EIF6 lysate HEK293 N/A
Human EIF6-671H Recombinant Human EIF6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF6-4305HF Recombinant Full Length Human EIF6 Protein, GST-tagged In Vitro Cell Free System GST 245 amino acids
Mouse EIF6-5119M Recombinant Mouse EIF6 Protein Mammalian Cell His
Mouse Eif6-2794M Recombinant Mouse Eif6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse EIF6-2728M Recombinant Mouse EIF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EIF6-2728M-B Recombinant Mouse EIF6 Protein Pre-coupled Magnetic Beads HEK293
Rat EIF6-2072R Recombinant Rat EIF6 Protein Mammalian Cell His
Rat EIF6-1729R Recombinant Rat EIF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF6-1729R-B Recombinant Rat EIF6 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish EIF6-11182Z Recombinant Zebrafish EIF6 Mammalian Cell His
Chicken EIF6-2544C Recombinant Chicken EIF6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF6 Related Articles

EIF6 involved in several pathways and played different roles in them. We selected most pathways EIF6 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ribosome biogenesis in eukaryotesRIOK2;GNL3L;NXT1;NOP58;RCL1;NOP10;RIOK1;RPP25;XPO1

EIF6 has several biochemical functions, for example, protein binding, ribosomal large subunit binding, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF6 itself. We selected most functions EIF6 had, and list some proteins which have the same functions with EIF6. You can find most of the proteins on our site.

Function Related Protein
protein bindingMDM4;NFIX;TCF12;CXorf48;HSPB2;ZFPL1;NXF1;ASUN;MRE11A
ribosomal large subunit bindingMRRF;NMD3;RBM3;OLA1;NPM1;MALSU1;CPEB2;EIF6
ribosome bindingEIF3K;WIBG;ETF1A;NAA16;ERI1;RPSA;ETF1;MTOR;EIF2S1
translation initiation factor activityAGO2;EIF1B;EIF1AXA;BRF1A;EIF4A2;EIF5;EIF4A1A;EIF4EB;EIF4BB

EIF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF6.

NREP; EIF2AK2; DHX58; OAS3; Prkcb; q96nr0_human

Vreugde, S; Ferrai, C; et al. Nuclear myosin VI enhances RNA polymerase II-dependent transcription. MOLECULAR CELL 23:749-755(2006).
Si, K; Chaudhuri, J; et al. Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94:14285-14290(1997).
  • Q&As
  • Reviews

Q&As (7)

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How does EIF6 influence stress responses in cells, particularly under conditions of nutrient deprivation or hypoxia? 05/09/2022

EIF6 helps cells respond to stress, adapting protein synthesis under nutrient deprivation or hypoxic conditions.

How does EIF6 (Eukaryotic Translation Initiation Factor 6) regulate ribosome assembly and protein synthesis? 03/12/2022

EIF6 is crucial for ribosome assembly and regulates the initiation of protein synthesis in eukaryotic cells.

What role does EIF6 play in controlling the translation of specific mRNAs in cells? 12/14/2020

EIF6 plays a role in selectively controlling the translation of specific mRNA molecules.

How does EIF6 contribute to cellular growth and proliferation? 11/28/2020

EIF6 contributes to cellular growth by facilitating efficient protein synthesis, necessary for cell proliferation.

How do alterations in EIF6 expression or activity affect the development of metabolic disorders? 07/14/2020

Changes in EIF6 activity can impact metabolic processes, potentially leading to the development of metabolic disorders.

What is the impact of EIF6 dysregulation on cancer development and progression? 01/28/2020

Dysregulation of EIF6 can lead to abnormal protein synthesis, contributing to cancer development and progression.

What are the mechanisms by which EIF6 modulates cell cycle progression and differentiation? 10/18/2019

EIF6 influences cell cycle and differentiation by modulating the synthesis of key regulatory proteins.

Customer Reviews (3)

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Reviews
08/25/2022

    Dependable expertise in protein engineering, unmatched in quality.

    12/11/2021

      Invaluable protein-protein interaction assays, integral to our research.

      01/28/2020

        Swift protein sequencing, invaluable for protein identification.

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