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Recombinant Human EIF6 protein, T7-tagged

Cat.No. : EIF6-141H
Product Overview : Recombinant human EIF6 (245 aa, Isoform-A) fused with T7 Tag at N-terminal was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : T7
Form : 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
AA Sequence : MASMTGGQQMGRGEFMAVRASFENN CEIGCFAKLTNTYCLVAIGGSENFY SVFEGELSDTIPVVHASIAGCRIIG RMCVGNRHGLLVPNNTTDQELQHIR NSLPDTVQIRRVEERLSALGNVTTC NDYVALVHPDLDRETEEILADVLKV EVFRQTVADQVLVGSYCVFSNQGGL VHPKTSIEDQDELSSLLQVPLVAGT VNRGSEVIAAGMVVNDWCAFCGLDT TSTELSVVESVFKLNEAQPSTIATS MRDSLIDSLT
Purity : >90% by SDS-PAGE
Applications : 1. May be used for in vitro EIF6 mediated ribosome biogenesis pathway regulation study with intracellular delivery of this protein.2. As soluble / native protein, may be used as enzymatic substrate protein for kinase and ubiquitin assay development.3. May be used for mapping EIF6 protein-protein interaction.4. Potential diagnostic biomarker for various diseases, such as Shwachman-Diamond syndrome.5. May be used as antigen for specific antibody development.
Storage : Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 7 days.
Gene Name : EIF6 eukaryotic translation initiation factor 6 [ Homo sapiens ]
Official Symbol : EIF6
Synonyms : EIF6; eukaryotic translation initiation factor 6; EIF3A, integrin beta 4 binding protein , ITGB4BP; b(2)gcn; p27BBP; B4 integrin interactor; p27 beta-4 integrin-binding protein; eukaryotic translation initiation factor 3A; CAB; EIF3A; eIF-6; ITGB4BP; p27(BBP);
Gene ID : 3692
mRNA Refseq : NM_002212
Protein Refseq : NP_002203
MIM : 602912
UniProt ID : P56537
Chromosome Location : 20q11.2
Pathway : Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Ribosome biogenesis in eukaryotes, organism-specific biosystem; Ribosome biogenesis in eukaryotes, conserved biosystem; Translation Factors, organism-specific biosystem;
Function : protein binding; ribosome binding; translation initiation factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does EIF6 influence stress responses in cells, particularly under conditions of nutrient deprivation or hypoxia? 05/09/2022

EIF6 helps cells respond to stress, adapting protein synthesis under nutrient deprivation or hypoxic conditions.

How does EIF6 (Eukaryotic Translation Initiation Factor 6) regulate ribosome assembly and protein synthesis? 03/12/2022

EIF6 is crucial for ribosome assembly and regulates the initiation of protein synthesis in eukaryotic cells.

What role does EIF6 play in controlling the translation of specific mRNAs in cells? 12/14/2020

EIF6 plays a role in selectively controlling the translation of specific mRNA molecules.

How does EIF6 contribute to cellular growth and proliferation? 11/28/2020

EIF6 contributes to cellular growth by facilitating efficient protein synthesis, necessary for cell proliferation.

How do alterations in EIF6 expression or activity affect the development of metabolic disorders? 07/14/2020

Changes in EIF6 activity can impact metabolic processes, potentially leading to the development of metabolic disorders.

What is the impact of EIF6 dysregulation on cancer development and progression? 01/28/2020

Dysregulation of EIF6 can lead to abnormal protein synthesis, contributing to cancer development and progression.

What are the mechanisms by which EIF6 modulates cell cycle progression and differentiation? 10/18/2019

EIF6 influences cell cycle and differentiation by modulating the synthesis of key regulatory proteins.

Customer Reviews (3)

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Reviews
08/25/2022

    Dependable expertise in protein engineering, unmatched in quality.

    12/11/2021

      Invaluable protein-protein interaction assays, integral to our research.

      01/28/2020

        Swift protein sequencing, invaluable for protein identification.

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