ELAVL1
-
Official Full Name
ELAV like RNA binding protein 1
-
Overview
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3 untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012] -
Synonyms
ELAVL1; ELAV like RNA binding protein 1; HUR; Hua; MelG; ELAV1; ELAV-like protein 1; Hu antigen R; hu-antigen R; embryonic lethal, abnormal vision, drosophila, homolog-like 1; ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ELAVL1 involved in several pathways and played different roles in them. We selected most pathways ELAVL1 participated on our site, such as AMPK signaling, AMPK signaling pathway, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELAVL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
AMPK signaling | ADRa1A;LOC729991;CPT1B;CPT1A;CDKN1A;SLC2A4RG;PPARGC1B;INS-IGF2;ELAVL1 |
AMPK signaling pathway | ACACA;PIK3R1;RAB14;CREB3L4;GYS1;PPP2R2A;CREB1;PPP2R5B;RPTOR |
Gene Expression | PTBP1;FAUB;ZNF573;ZNF192;ZNF2;CLNS1A;TXNL4A;SEC61B;NR2C2 |
HuR (ELAVL1) binds and stabilizes mRNA | SETB;SETA;HUG;ELAVL1;SET;ANP32A |
Regulation of mRNA stability by proteins that bind AU-rich elements | SETB;ZFP36L1B;KHSRP;HNRNPD;HUG;ANP32A;SET;ELAVL1;SETA |
ELAVL1 has several biochemical functions, for example, AU-rich element binding, RNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELAVL1 itself. We selected most functions ELAVL1 had, and list some proteins which have the same functions with ELAVL1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
AU-rich element binding | EXOSC7;EXOSC9;APOBEC1;ZFP36L1;HNRNPA0;ZFP36;ELAVL4;ELAVL1;NUDT21 |
RNA binding | HBP1;TRIM71;NSUN3;MKI67IP;MARF1;RPL18A;LRPPRC;RPL30;SETD1B |
double-stranded RNA binding | VIM;OASL2;LRRFIP1;ELAVL1;STRBP;OAS1B;EIF2AK2;APTX;TUBA1B |
mRNA 3-UTR AU-rich region binding | CPEB2;CPSF1;CPEB1;CPEB3;ZFP36;ELAVL1;CPEB1B |
mRNA 3-UTR binding | ZNF385A;RBM24;ANGEL2;SERBP1;RBM24A;CRYZ;CPEB4;RIMS2;CPEB1B |
mRNA binding | THOC2;SNRPC;ZFP36L1;C1QBP;RPS26;NCBP2;G3BP1;ELAVL1;NANOS2 |
nucleotide binding | ABCA9;ABCD3A;MTIF2;TNIKB;RTCB;RBM15;CPEB1A;SLC27A4;RBM7 |
poly(A) RNA binding | CCBL2;EIF5A;EIF2AK2;EZR;EMG1;PFN1;STRBP;TAF15;NAP1L1 |
protein binding | ST6GAL1;DYRK4;MASP1;IRF4;MPL;RBM39;FRAG1;ADAMTS10;SLC48A1 |
protein kinase binding | ADAM10;PAK2;PIFO;TRAF6;CNPPD1;CD4;ELAVL1;SYN1;CCND3 |
ELAVL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELAVL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELAVL1.
SDCBP; q99ib8-pro_0000045602; TOP1; Smurf2; UBC; SF3A2; RBFOX2; GJB3; PTBP1; NOS3
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that the ELAVL1 gene may be involved in the regulation of the immune system, especially in the inflammatory response.
The protein encoded by the ELAVL1 gene is mainly located in the cytoplasm and nucleus.
In some tumors, the expression level of ELAVL1 gene may be increased or decreased, which is related to the occurrence and progression of tumors.
This gene may play an important role in the process of apoptosis, but its specific mechanism of action still needs further research.
ELAVL1 is involved in the differentiation of nerve cells by binding to and stabilizing neuronal cell-specific microRNAs.
This gene isexpressed in many tissues and organs, including the brain, heart, liver, muscles, etc.
Customer Reviews (3)
Write a reviewIt is very pure and can be used with confidence.
In enzymatic experiments, ELAVL1 was found to have high catalytic efficiency.
In immunological experiments, it was found that ELAVL1 had good antigenicity and could induce target immune response.
Ask a Question for All ELAVL1 Products
Required fields are marked with *
My Review for All ELAVL1 Products
Required fields are marked with *