elavl1
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  • Official Full Name
  • ELAV like RNA binding protein 1
  • Background
  • The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3 untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
  • Synonyms
  • ELAVL1; ELAV like RNA binding protein 1; HUR; Hua; MelG; ELAV1; ELAV-like protein 1; Hu antigen R; hu-antigen R; embryonic lethal, abnormal vision, drosophila, homolog-like 1; ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R);
Cat.#:ELAVL1-01HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ELAVL1(1-326aa), GST-tagged
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Cat.#:ELAVL1-02HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ELAVL1(1-100aa), GST-tagged
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Cat.#:ELAVL1-5123MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ELAVL1 Protein
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Cat.#:ELAVL1-6396CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ELAVL1
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Cat.#:ELAVL1-9020ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ELAVL1
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Cat.#:ELAVL1-6637HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ELAVL1 293 Cell Lysate
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Involved Pathway

ELAVL1 involved in several pathways and played different roles in them. We selected most pathways ELAVL1 participated on our site, such as AMPK signaling, AMPK signaling pathway, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELAVL1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AMPK signaling
LOC729991; PPARGC1B; ADRa1A; INS-IGF2; CPT1C; ADRA1B; EEF2; CPT1B; CDKN1A; SLC2A4RG
AMPK signaling pathway
STRADA; PFKP; CREB1; CAMKK1; ADIPOR2; PPP2R1B; RPTOR; PFKFB3; FASN; CPT1A
Gene Expression
MED25; SMARCA5; SUPT16H; PTBP1A; NKX2; COX16; GM3258; TUBB3; EXOSC8; ZNF317
HuR (ELAVL1) binds and stabilizes mRNA
SET; ELAVL1; SETA; HUG; ANP32A; SETB
Regulation of mRNA stability by proteins that bind AU-rich elements
TNPO1; SET; ZFP36L1B; KHSRP; ZFP36L1; ANP32A; SETB; SETA; ELAVL1; HUG

Protein Function

ELAVL1 has several biochemical functions, for example, AU-rich element binding, RNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELAVL1 itself. We selected most functions ELAVL1 had, and list some proteins which have the same functions with ELAVL1. You can find most of the proteins on our site.
Function
Related Protein
Function AU-rich element binding
Related Protein APOBEC1; EXOSC8; DND1; EXOSC7; EXOSC4; ZFP36; TIAL1; ELAVL1; ZFP36L1; ZFP36L3
Function RNA binding
Related Protein RBMS3; UBR5; CAPRIN2; DIS3; AGFG1; HENMT1; APOBEC3G; EIF3K; RPL13; RPS14
Function double-stranded RNA binding
Related Protein IFIH1; YRDC; TUBB4B; ADARB1; OASL1; ILF2; TARBP2; DROSHA; OAS2; HMGB1
Function mRNA 3-UTR AU-rich region binding
Related Protein CPSF1; ELAVL1; CPEB1B; CPEB2; ZFP36; CPEB1; CPEB3
Function mRNA 3-UTR binding
Related Protein PPP1R2P9; TARDBP; CPEB1A; AUH; RBM38; CPEB1; CARHSP1; RBM24; RBM4; RBM24A
Function mRNA binding
Related Protein TDRD7; D19BWG1357E; RBFOX3; KHSRP; RBPMS2B; SNRNP70; CROP; MRPL13; CELF4; MECP2
Function nucleotide binding
Related Protein HNRPDL; NAIP6; ADCY1A; RBM34; HNRNPH3; CAMK1GA; UBE2D2A; RAB32A; TRIM66; RBFOX2
Function poly(A) RNA binding
Related Protein TNRC6B; TCP1; RPL5B; MRPL3; MYEF2; TRUB2; NUFIP2; EFTUD2; ALKBH5; CKAP4
Function protein binding
Related Protein ZNF426; PEAK1; NUCB2; P2RY6; C2orf28; GLYR1; MTUS2; ADRB2; PSMD6; SETDB2
Function protein kinase binding
Related Protein RCC2; CDKN2A; ELAVL1; GCET2; CD24; IKBKB; PPP1R15A; GHR; MAPK6; TCF7L2

Interacting Protein

ELAVL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELAVL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELAVL1.
SDCBP; q99ib8-pro_0000045602; TOP1; Smurf2; UBC; SF3A2; RBFOX2; GJB3; PTBP1; NOS3