ephb4
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  • Official Full Name
  • EPH receptor B4
  • Background
  • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to
  • Synonyms
  • EPHB4; EPH receptor B4; EphB4 , HTK; ephrin type-B receptor 4; Tyro11; ephrin receptor EphB4; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; hepatoma transmembrane kinase; tyrosine-protein kinase TYRO11; tyrosine-protein kinase
Cat.#:EPHB4-003HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human EPHB4 Protein, His-tagged
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Cat.#:EPHB4-363HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHB4 Protein (Met1-Ala539), His-tagged, Biotinylated
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Cat.#:EPHB4-1898HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4 Protein, MYC/DDK-tagged
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Cat.#:EPHB4-3403HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHB4 Protein, GST-tagged
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Cat.#:EPHB4-3404HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPHB4 Protein, GST-tagged
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Cat.#:Ephb4-1729MTag:Fc|His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Eph Receptor B4, Fc-His
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Cat.#:EPHB4-543HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EPH Receptor B4, His-tagged
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Cat.#:EPHB4-12495HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPHB4, GST-tagged
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Cat.#:EPHB4-231HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4, C13&N15-labeled
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Cat.#:EPHB4-28580THTag:His
Source (Host):Species:Human
Product nameRecombinant Human EPHB4, His-tagged
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Cat.#:EPHB4-28623THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EPHB4
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Cat.#:EPHB4-306HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EPH Receptor B4, GST-tagged, Active
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Cat.#:EPHB4-356HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4 protein, His-tagged, Biotinylated
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Cat.#:EPHB4-378HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4 Protein, DDK/His-tagged
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Cat.#:EPHB4-379HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHB4 Protein, DDK-tagged
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Cat.#:EPHB4-4762HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPH Receptor B4, His-tagged
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Cat.#:EPHB4-695HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4, Fc tagged
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Cat.#:EPHB4-696HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4, His tagged
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Cat.#:EPHB4-697HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4, None tagged
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Cat.#:EPHB4-7278HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHB4, His & GST tagged
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Cat.#:Ephb4-4052MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ephb4, Fc tagged
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Cat.#:Ephb4-4053MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ephb4, His tagged
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Cat.#:EPHB4-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHB4 cell lysate
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Cat.#:EPHB4-2970HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB4 cell lysate
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Cat.#:EPHB4-2128MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EPHB4 cell lysate
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Cat.#:Kit-1548Tag:N/A
Source (Host):Species:
Product nameU2OS EphB4 Bioassay Kit
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Cat.#:Kit-1585Tag:N/A
Source (Host):Species:
Product nameEphB4 Functional Assay Kit
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Involved Pathway

EPHB4 involved in several pathways and played different roles in them. We selected most pathways EPHB4 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
ANK2B; CD24; CSNK2A1; HRAS; FES; SEMA3B; NRP2; NRG3; L1CAM; DPYSL2

Protein Function

EPHB4 has several biochemical functions, for example, ATP binding, ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHB4 itself. We selected most functions EPHB4 had, and list some proteins which have the same functions with EPHB4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TOR1A; KIFC1; TNIK; GSK3AA; ERBB3; TPK1; YSK4; MAP3K8; KIF27; TYK2
Function ephrin receptor activity
Related Protein EPHA10; EPHA4A; EPHA5; EPHB4; EPHB3; EPHB6; EPHA2; EPHB4B; EPHA2A; EPHB4A
Function protein binding
Related Protein SRSF3; STT3A; ARRB2; MYLK2; ORC6L; NLK; GUCY1B3; TBL1X; ESRRG; OTULIN
Function transmembrane receptor protein tyrosine kinase activity
Related Protein EGFR; EPHB4A; INSRB; MERTK; TEK; INSRR; LTK; RYK; EPHB3A; KIT

Interacting Protein

EPHB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHB4.
bosutinib; dasatinib; saicar; ephopt; PKM; abl-tide; JUN; linkable pd173955 analogue; linkable vandetanib analogue; imatinib; purvalanol b; crizotinib; EGFR; ZSCAN5A; PARD6A; Skp1

EPHB4 Related Articles

Liu, SL; Li, D; et al. Design, Synthesis, and Validation of Axl-Targeted Monoclonal Antibody Probe for microPET Imaging in Human Lung Cancer Xenograft. MOLECULAR PHARMACEUTICS 11:3974-3979(2014).
Nagano, K; Maeda, Y; et al. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers. JOURNAL OF CONTROLLED RELEASE 189:72-79(2014).