Species : |
Human |
Source : |
Insect Cells |
Tag : |
His |
Protein Length : |
16-539 a.a. |
Description : |
EPHB4, also known ephrin type-B receptor 4, is a member of the Eph receptor tyrosine kinase family. It binds transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. This protein plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. And the signaling of this protein controls cellular repulsion and segregation form EFNB2-expressing cells. And it also plays a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. |
Form : |
Liquid |
Molecular Mass : |
58.1 kDa (532aa) |
AA Sequence : |
LEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLAVEHHHHHH |
N-terminal Sequence Analysis : |
Leu 16 |
Endotoxin : |
< 1.0 EU per 1μg of protein (determined by LAL method) |
Purity : |
> 90% by SDS-PAGE |
Notes : |
For research use only. This product is not intended or approved for human, diagnostics or veterin. |
Storage : |
Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : |
0.25 mg/mL (determined by Absorbance at 280nm) |
Storage Buffer : |
In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |