Expand| Cat.No. : | EPHB4-003H |
| Product Overview : | Recombinant human EPHB4 protein(16-539aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Description : | EPHB4, also known ephrin type-B receptor 4, is a member of the Eph receptor tyrosine kinase family. It binds transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. This protein plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. And the signaling of this protein controls cellular repulsion and segregation form EFNB2-expressing cells. And it also plays a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. |
| Source : | Insect cell |
| Species : | Human |
| Tag : | His |
| Form : | Liquid |
| Molecular Mass : | 58.1 kDa (532aa) |
| AA Sequence : | LEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLAVEHHHHHH |
| N-terminal Sequence Analysis : | Leu 16 |
| Endotoxin : | < 1.0 EU per 1μg of protein (determined by LAL method) |
| Purity : | > 90% by SDS-PAGE |
| Notes : | For research use only. This product is not intended or approved for human, diagnostics or veterin. |
| Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : | 0.25 mg/mL (determined by Absorbance at 280nm) |
| Storage Buffer : | In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| SDS-PAGE : |
15% SDS-PAGE (3μg) |
| Gene Name : | EPHB4 EPH receptor B4 [ Homo sapiens (human) ] |
| Official Symbol : | EPHB4 |
| Synonyms : | EPHB4; HFASD; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; ephrin type-B receptor 4; ephrin receptor EphB4; hepatoma transmembrane kinase; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; tyrosine-protein kinase TYRO11; tyrosine-protein kinase receptor HTK; EC 2.7.10.1 |
| Gene ID : | 2050 |
| mRNA Refseq : | NM_004444 |
| Protein Refseq : | NP_004435 |
| MIM : | 600011 |
| UniProt ID : | P54760 |
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