etv6
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  • Official Full Name
  • ets variant 6
  • Background
  • This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
  • Synonyms
  • ETV6; ets variant 6; TEL; TEL/ABL; transcription factor ETV6; TEL1 oncogene; ETS-related protein Tel1; ETS translocation variant 6; ets variant gene 6 (TEL oncogene);
Cat.#:ETV6-3540HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ETV6 Protein, GST-tagged
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Cat.#:ETV6-5354MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ETV6 Protein
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Cat.#:ETV6-1512RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ETV6 Protein, His-tagged
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Cat.#:ETV6-4254CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ETV6
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Cat.#:ETV6-8526ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ETV6
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Cat.#:ETV6-9341ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ETV6
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Cat.#:ETV6-6519HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ETV6 293 Cell Lysate
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Involved Pathway

ETV6 involved in several pathways and played different roles in them. We selected most pathways ETV6 participated on our site, such as Dorso-ventral axis formation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETV6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dorso-ventral axis formation
SPIRE2; NOTCH2; MAP2K1; PIWIL4; GRB2; MAPK1; NOTCH3; MAPK3; NOTCH1; EGFRA
Transcriptional misregulation in cancer
BCL2L1; GRIA3; RUNX1T1; Bcl2a1b; FCGR1A; MAF; HIST1H3E; LDB1; IGFBP3; PROM1

Protein Function

ETV6 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETV6 itself. We selected most functions ETV6 had, and list some proteins which have the same functions with ETV6. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein SMAD1; ARNT2; CLOCK; FUBP3; NRL; TFAP4; TP73; JDP2; CEBPZ; POU4F2
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein ALX4; ZNF691; NHLH2; ZNF256; CDX1A; RXRA; HMX3; MEF2C; ESX1; ZGLP1
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein MITFB; FOXJ1A; ERF; FOXO3B; TAL2; FOXD5; NPAS4A; ETV4; JUNBA; LYL1
Function protein binding
Related Protein WWTR1; MCCC1; CCNA1; RNF149; RAB11B; JMY; AIRE; CD48; CST5; NDRG4
Function protein domain specific binding
Related Protein MTOR; PLAUR; IGBP1; EZR; LIN7C; CNOT1; VPS4A; WNT1; MRPL17; NEDD4
Function transcription factor activity, sequence-specific DNA binding
Related Protein TEAD3; ZFP821; TCF3B; ATF2; ZFP37; SOX32; NPAS2; CREBBP; SNAPC2; ZFP382
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CEBPE; ZFP292; CREB3L1; TFE3A; TFAP2E; MZF1; MEF2B; YBX1; POU4F1; MESP1
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein BCL6; E4F1; AEBP1; ESX1; CHCHD3; NFKB1; JARID2; HIST2H3A; FERD3L; KLF6A

Interacting Protein

ETV6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETV6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETV6.
WDYHV1; AP1M1; HDAC9; HDAC9; HDAC9; HDAC9; UBE2I; q81la6_bacan; fldB; MYC; SNW1; VPS26B; USP7

ETV6 Related Articles

Manda, SS; Nirujogi, RS; et al. Identification and Characterization of Proteins Encoded by Chromosome 12 as Part of Chromosome-centric Human Proteome Project. JOURNAL OF PROTEOME RESEARCH 13:3166-3177(2014).
Linka, Y; Ginzel, S; et al. The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods. BLOOD CANCER JOURNAL 3:-(2013).