efemp1
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  • Official Full Name
  • EGF containing fibulin-like extracellular matrix protein 1
  • Background
  • This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.
  • Synonyms
  • EFEMP1; EGF containing fibulin-like extracellular matrix protein 1; DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3; EGF-containing fibulin-like extracellular matrix protein 1; fibulin-3; extracellular protein S1-5
Cat.#:EFEMP1-2166MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse EFEMP1 Protein (18-493 aa), His-tagged
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Cat.#:EFEMP1-234HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EFEMP1 Protein, His-tagged
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Cat.#:EFEMP1-3085HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EFEMP1 Protein, GST-tagged
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Cat.#:Efemp1-236RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Efemp1 Protein, His-tagged
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Cat.#:EFEMP1-27780THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EFEMP1
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Cat.#:EFEMP1-501HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFEMP1, MYC/DDK-tagged
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Cat.#:EFEMP1-68HTag:HA
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EFEMP1 protein, HA-tagged
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Cat.#:EFEMP1-5019MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EFEMP1 Protein
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Cat.#:EFEMP1-6705HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EFEMP1 293 Cell Lysate
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Involved Pathway

EFEMP1 involved in several pathways and played different roles in them. We selected most pathways EFEMP1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFEMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Elastic fibre formation
FURINB; FBN1; MFAP2; EFEMP2; FURINA; LOXL1; ABHD1; MFAP1B; LOXL4; LOX
Extracellular matrix organization
EFEMP2; ABHD1; ADAM9; ITGB3A; ADAMTS5; COL5A1; CTSG; COL5A3A; DAG1; COL11A1B
Molecules associated with elastic fibres
EFEMP2; MFAP4; MFAP1B; MFAP3; EFEMP1; LTBP4; LTBP2; FBLN2; MFAP2; MFAP1

Protein Function

EFEMP1 has several biochemical functions, for example, calcium ion binding, epidermal growth factor receptor binding, epidermal growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFEMP1 itself. We selected most functions EFEMP1 had, and list some proteins which have the same functions with EFEMP1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CDH5; PLCD1; GPD2; NCS1B; SYT4; FBLN1; CAPN13; CDH23; CRB2B; EFCC1
Function epidermal growth factor receptor binding
Related Protein EGF; RNF126; SNX1; ERBB4; EFEMP1; BTC; TNK2; MS4A1; ATXN2; HBEGFA
Function epidermal growth factor-activated receptor activity
Related Protein EFEMP1; EGFR
Function growth factor activity
Related Protein FGF8B; FGF12; PROK1; FGF2; IL7; NOV; NDR1; FGF1A; RABEP2; Fgf15
Function protein binding
Related Protein WDR4; TMEM88; FAM127C; RCHY1; COPS5; ID2; HNRNPF; CLK4; CACNG1; DOK2

Interacting Protein

EFEMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFEMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFEMP1.
SGTA; BAG6; TRAF2; TXNDC5; RIC8A; q9wmx2-pro_0000037551; PDIA3; CACNA1A