EFEMP1
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Official Full Name
EGF containing fibulin-like extracellular matrix protein 1
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Overview
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described. -
Synonyms
EFEMP1; EGF containing fibulin-like extracellular matrix protein 1; DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3; EGF-containing fibulin-like extracellular matrix protein 1; fibulin-3; extracellular protein S1-5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- Myc
- GST
- HA
- His
- His (Fc)
- Avi
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- EFEMP1 Related Research Area
EFEMP1 involved in several pathways and played different roles in them. We selected most pathways EFEMP1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFEMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Elastic fibre formation | LOXL2;LOXL4;FBN1;FBLN1;EFEMP1;ITGB3A;BMP10;LTBP4;LOX |
| Extracellular matrix organization | ASPN;VCANB;LTBP2;CEACAM1;MFAP5;MATN3;DDR2;COL6A2;COL8A1 |
| Molecules associated with elastic fibres | BMP10;EFEMP1;MFAP5;LTBP3;LTBP2;EFEMP2;MFAP1;MFAP4;LTBP4 |
EFEMP1 has several biochemical functions, for example, calcium ion binding, epidermal growth factor receptor binding, epidermal growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFEMP1 itself. We selected most functions EFEMP1 had, and list some proteins which have the same functions with EFEMP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH1GC5;PCDHGA5;CALM4;ACTN2;CLSTN3;PCDHA6;CALB1;PLCD1A;DSG2.1 |
| epidermal growth factor receptor binding | MS4A1;TNK2;SNX1;SNX4;SHC1;YES1;VAV3;Fert2;ATXN2 |
| epidermal growth factor-activated receptor activity | EFEMP1;EGFR |
| growth factor activity | FGF1;GSDF;EPGN;AMH;IGF2B;GPI;MDKA;FGF4;GH1 |
| protein binding | MYO7B;VCL;NR3C2;CHMP1B;THBS4;ZKSCAN5;EGLN3;RAB8B;EMX2 |
EFEMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFEMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFEMP1.
SGTA; BAG6; TRAF2; TXNDC5; RIC8A; q9wmx2-pro_0000037551; PDIA3; CACNA1A
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