f11r
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  • Official Full Name
  • F11 receptor
  • Background
  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5 alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
  • Synonyms
  • F11R; F11 receptor; JAM1, junctional adhesion molecule 1; junctional adhesion molecule A; CD321; JAM 1; JAM A; JAMA; JCAM; PAM 1; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1; JAM; KAT; JAM1; PAM-1
Cat.#:F11R-3604HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F11R Protein
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Cat.#:F11R-3605HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F11R Protein, GST-tagged
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Cat.#:F11R-961HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human F11R Protein, MYC/DDK-tagged
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Cat.#:F11R-181HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human F11R Protein
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Cat.#:F11R-6785HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F11 Receptor, His-tagged
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Cat.#:F11R-69HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human F11R, Fc tagged
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Cat.#:F11R-788HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human F11 Receptor, His-tagged
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Cat.#:F11R-790HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human F11R, His tagged
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Cat.#:F11r-1057MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse F11r Protein, Fc Chimera
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Cat.#:F11r-4032MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse F11r, Fc tagged
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Cat.#:F11R-2175RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat F11R Protein
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Cat.#:F11r-7470RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat F11r, Fc tagged
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Cat.#:F11r-8744RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat F11r, His tagged
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Cat.#:F11R-1530RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey F11R Protein, His-tagged
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Cat.#:F11R-1731RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey F11R Protein
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Cat.#:F11R-1732RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey F11R Protein, hIgG1-tagged
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Cat.#:F11R-1733RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey F11R Protein, hIgG4-tagged
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Cat.#:F11R-3682CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken F11R
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Cat.#:F11R-2741HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human F11R cell lysate
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Cat.#:F11R-2127MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse F11R cell lysate
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Cat.#:F11R-1437RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat F11R cell lysate
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Involved Pathway

F11R involved in several pathways and played different roles in them. We selected most pathways F11R participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with F11R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
ITGB8; ITGA6B; CLDN11A; CLDN18; CLDN9; CLDN6; CD34; LRRC4C; PVRL3B; CD8B1
Tight junction
PARD6A; INADL; SPTAN1; PPP2R2B; CLDNB; EPB41L1; YBX3; PRKCE; ACTB; AKT3A
Leukocyte transendothelial migration
NOX3; ICAM1; CLDN14; CLDN8; CLDN16; MYLPF; CYBA; PRKCB; MLLT4; CYBB
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1B1; NOD1; ATP6V1F; ATP6V1C1; IL-8; ATP6V1E1; ATP6AP1; PLCG2; MAPK8; MAP3K14

Protein Function

F11R has several biochemical functions, for example, PDZ domain binding, protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F11R itself. We selected most functions F11R had, and list some proteins which have the same functions with F11R. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein ARHGAP29; TGFBR3; GRIK2; GRASP; PTENB; Fzd4; TBC1D10A; LPAR1; ACVR2A; CCDC88C
Function protein binding
Related Protein PCSK2; FGFRL1A; ZNF202; NAV2; KRT86; TDP1; ORAI3; SERPING1; MAPKAPK2; SMARCA2
Function virus receptor activity
Related Protein LAMP1; SLC52A2; CD46; ITGB1; ITGA5; TYRO3; TNFRSF4; HTR2A; EFNB2; SLC20A2

Interacting Protein

F11R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F11R here. Most of them are supplied by our site. Hope this information will be useful for your research of F11R.
SGTA; PRKCZ; PARD3; BDNF; PEX19; CASK

F11R Related Articles

Babinska, A; Clement, CC; et al. Development of New Antiatherosclerotic and Antithrombotic Drugs Utilizing F11 Receptor (F11R/JAM-A) Peptides. BIOPOLYMERS 102:322-334(2014).
Schmitt, MMN; Fraemohs, L; et al. Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution. ATHEROSCLEROSIS 234:254-264(2014).