Recombinant Human F11 Receptor, His-tagged

• Cat.No.: F11R-6785H
• Product Overview: Recombinant humanF11R protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: F11R, also known asCD321, belongs to the immunoglobulin superfamily. It seems to plays a role inepithelial tight junction formation. Tight junctions represent one mode ofcell-to-cell adhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier to preventsolutes and water from passing freely through the paracellular space. F11Rprotein can act as (1) a receptor for reovirus, (2) a ligand for the integrinLFA1, involved in leukocyte transmigration, and (3) a platelet receptor
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 10% glycerol 0.15M NaCl,1mM DTT
• Molecular Weight: 25.8kDa (238aa),confirmed by MALDI-TOF
• Purity: > 90% by SDS -PAGE
• Concentration: 1 mg/ml (determinedby BCA assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMLGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKITASYEDRVTFLPTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAVLTCSEQDGSP PSEYTWFKDG IVMPTNPKSTRAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGTPMTSNAVRME AVERNVGV
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Cell adhesion molecules (CAMs);Epithelial cell signaling in Helicobacter pylori infection; Leukocytetransendothelial migration; Tight junction; Cell-cell adhesion systems;Hemostasis; Integrin cell surface interactions; Signaling in Immune system

Gene Information

• Gene Name: F11RF11 receptor [ Homo sapiens ]
• Official Symbol: F11R
• Synonyms: F11R; F11 receptor; JAM; KAT; JAM1;JAMA; JCAM; CD321; PAM-1; junctional adhesion molecule 1; Junctional adhesionmolecule A; JAM-A; Junctional adhesion molecule 1; Platelet adhesion molecule1; JAM-1; OTTHUMP00000027880; Platelet F11 receptor; OTTHUMP00000027881;CD321 antigen
• Gene ID: 50848
• mRNA Refseq: NM_016946
• Protein Refseq: NP_058642
• MIM: 605721
• UniProt ID: Q9Y624
• Chromosome Location: 1q21.2-q21.3
• Function: Protein binding