f12
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  • Official Full Name
  • coagulation factor XII
  • Background
  • Coagulation factor XII also known as Hageman factor is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene.
  • Synonyms
  • coagulation factor XII (Hageman factor); F12; HAF; HAE3; HAEX; coagulation factor XII; Hageman factor; OTTHUMP00000223845; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain
Cat.#:F12-3606HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F12 Protein, GST-tagged
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Cat.#:F12 -82HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Factor XII
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Cat.#:F12-12617HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F12, His-tagged
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Cat.#:F12-773HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F12 protein, His & T7-tagged
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Cat.#:F12-5406MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse F12 Protein
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Cat.#:F12-774MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse F12 protein, His & T7-tagged
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Cat.#:F12 -101RTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Coagulation Factor XII
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Cat.#:F12-2176RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat F12 Protein
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Cat.#:F12-13HTag:N/A
Source (Host):Species:Human
Product nameNative Human Factor beta-XIIa, Biotin Labeled
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Cat.#:F12-28805THTag:
Source (Host):Species:Human
Product nameNative Human F12
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Cat.#:F12-5397HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Coagulation Factor XII (Hageman factor)
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Cat.#:F12-2115HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human F12 cell lysate
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Involved Pathway

F12 involved in several pathways and played different roles in them. We selected most pathways F12 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
KLKB1; MASP1; C5AR1; Serpina1c; SERPINF2; MBL2; C8B; GM5077; C1QB; C4BPB

Protein Function

F12 has several biochemical functions, for example, misfolded protein binding, protein binding, serine-type aminopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F12 itself. We selected most functions F12 had, and list some proteins which have the same functions with F12. You can find most of the proteins on our site.
Function
Related Protein
Function misfolded protein binding
Related Protein BAG6; DNAJC3; HSPA5; TOR1A; CLU; EDEM1; DNAJB9; DNAJC10; F12; HDAC6
Function protein binding
Related Protein C22orf23; UBE2R2; ADAMTS4; SPTSSB; EML2; KLKB1; S100A11; SIGIRR; PIM3; TCTEX1D2
Function serine-type aminopeptidase activity
Related Protein F12
Function serine-type endopeptidase activity
Related Protein ST14A; PRSS54; TMPRSS4B; GZMA; MMP8; F9A; TPSG1; TMPRSS11B; FURINA; LOC100686744

Interacting Protein

F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of F12.
KNG1; C1QBP; GP1BA

F12 Related Articles

Karton, A; Goerigk, L; et al. Accurate Reaction Barrier Heights of Pericyclic Reactions: Surprisingly Large Deviations for the CBS-QB3 Composite Method and Their Consequences in DFT Benchmark Studies. JOURNAL OF COMPUTATIONAL CHEMISTRY 36:622-632(2015).
Ohnishi, Y; Ishimura, K; et al. Massively Parallel MP2-F12 Calculations on the K Computer. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY 115:333-341(2015).

F12 Related Gene Family

TNF Kinesins (KIF)