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Native Human F12

Cat.No. : F12-28805TH
Product Overview : Purified full length native human Factor XII protein (MW 80kDa), prepared from fresh frozen plasma
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Description : This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Form : Liquid
Purity : Immunogen affinity purified
Storage buffer : Preservative: NoneConstituents: 50% Glycerol
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase S1 family.Contains 2 EGF-like domains.Contains 1 fibronectin type-I domain.Contains 1 fibronectin type-II domain.Contains 1 kringle domain.Contains 1 peptidase S1 domain.
Tag : Non
Gene Name : F12 coagulation factor XII (Hageman factor) [ Homo sapiens ]
Official Symbol : F12
Synonyms : F12; coagulation factor XII (Hageman factor); coagulation factor XII;
Gene ID : 2161
mRNA Refseq : NM_000505
Protein Refseq : NP_000496
MIM : 610619
Uniprot ID : P00748
Chromosome Location : 5q33-qter
Pathway : Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem;
Function : binding; misfolded protein binding; peptidase activity; protein binding; serine-type endopeptidase activity;

Not For Human Consumption!

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Customer Reviews (3)

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06/23/2023

    Trustworthy data source. Valuable for our experiments.

    05/22/2022

      Accelerates research progress. Exceptional service provider.

      03/26/2018

        Enables data-driven decisions. A research necessity.

        Q&As (7)

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        What role does F12 play in thrombotic disorders? 05/30/2023

        Abnormalities in F12 can lead to increased risk of thrombosis and related disorders.

        How do genetic variations in the F12 gene affect coagulation and risk of bleeding or clotting disorders? 03/26/2022

        Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.

        How does F12 interact with other components of the coagulation and fibrinolytic systems? 10/01/2021

        F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.

        What is the impact of altered F12 activity on inflammation and immune response? 04/28/2021

        Altered F12 activity is associated with inflammation and can influence immune responses.

        What potential therapeutic applications could arise from targeting F12 in clotting or inflammatory disorders? 12/29/2019

        Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.

        How does F12 activation initiate the intrinsic pathway of coagulation? 10/05/2018

        Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.

        What is the primary function of Factor XII (F12) in the blood coagulation cascade? 03/23/2017

        Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.

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