Native Human F12
Cat.No. : | F12-28805TH |
Product Overview : | Purified full length native human Factor XII protein (MW 80kDa), prepared from fresh frozen plasma |
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Description : | This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. |
Form : | Liquid |
Purity : | Immunogen affinity purified |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the peptidase S1 family.Contains 2 EGF-like domains.Contains 1 fibronectin type-I domain.Contains 1 fibronectin type-II domain.Contains 1 kringle domain.Contains 1 peptidase S1 domain. |
Tag : | Non |
Gene Name : | F12 coagulation factor XII (Hageman factor) [ Homo sapiens ] |
Official Symbol : | F12 |
Synonyms : | F12; coagulation factor XII (Hageman factor); coagulation factor XII; |
Gene ID : | 2161 |
mRNA Refseq : | NM_000505 |
Protein Refseq : | NP_000496 |
MIM : | 610619 |
Uniprot ID : | P00748 |
Chromosome Location : | 5q33-qter |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; |
Function : | binding; misfolded protein binding; peptidase activity; protein binding; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
F12-2040P | Recombinant Pig F12 Protein (20-371 aa), His-tagged | +Inquiry |
F12-2916M | Recombinant Mouse F12 Protein, His (Fc)-Avi-tagged | +Inquiry |
F12-2005P | Recombinant Pig F12 Protein (20-371 aa), His-tagged | +Inquiry |
F12-909M | Recombinant Mouse F12 Protein, His-tagged | +Inquiry |
F12-3606H | Recombinant Human F12 Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
F12-13H | Native Human Factor beta-XIIa, Biotin Labeled | +Inquiry |
F12-5397H | Active Native Human Coagulation Factor XII (Hageman factor) | +Inquiry |
◆ Lysates | ||
F12-2115HCL | Recombinant Human F12 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewTrustworthy data source. Valuable for our experiments.
Accelerates research progress. Exceptional service provider.
Enables data-driven decisions. A research necessity.
Q&As (7)
Ask a questionAbnormalities in F12 can lead to increased risk of thrombosis and related disorders.
Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.
F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.
Altered F12 activity is associated with inflammation and can influence immune responses.
Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.
Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.
Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.
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