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Recombinant Mouse F12 protein, His & T7-tagged

Cat.No. : F12-774M
Product Overview : Recombinant Mouse F12 aa. (Phe352~Tyr587 (Accession # Q80YC5)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots.
Source : E. coli
Species : Mouse
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 29.1kDa
Protein length : Phe352~Tyr587 (Accession # Q80YC5)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.7.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : F12 coagulation factor XII (Hageman factor) [ Mus musculus (house mouse) ]
Official Symbol : F12
Synonyms : HAF; FXII; factor XII; coagulation factor XII; hageman factor
Gene ID : 58992
mRNA Refseq : NM_021489.3
Protein Refseq : NP_067464.2
UniProt ID : Q80YC5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does F12 play in thrombotic disorders? 05/30/2023

Abnormalities in F12 can lead to increased risk of thrombosis and related disorders.

How do genetic variations in the F12 gene affect coagulation and risk of bleeding or clotting disorders? 03/26/2022

Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.

How does F12 interact with other components of the coagulation and fibrinolytic systems? 10/01/2021

F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.

What is the impact of altered F12 activity on inflammation and immune response? 04/28/2021

Altered F12 activity is associated with inflammation and can influence immune responses.

What potential therapeutic applications could arise from targeting F12 in clotting or inflammatory disorders? 12/29/2019

Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.

How does F12 activation initiate the intrinsic pathway of coagulation? 10/05/2018

Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.

What is the primary function of Factor XII (F12) in the blood coagulation cascade? 03/23/2017

Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.

Customer Reviews (3)

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Reviews
06/23/2023

    Trustworthy data source. Valuable for our experiments.

    05/22/2022

      Accelerates research progress. Exceptional service provider.

      03/26/2018

        Enables data-driven decisions. A research necessity.

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