Recombinant Mouse F12 protein, His & T7-tagged
Cat.No. : | F12-774M |
Product Overview : | Recombinant Mouse F12 aa. (Phe352~Tyr587 (Accession # Q80YC5)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
- Specification
- Gene Information
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Description : | This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. |
Source : | E. coli |
Species : | Mouse |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 29.1kDa |
Protein length : | Phe352~Tyr587 (Accession # Q80YC5) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 5.7. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | F12 coagulation factor XII (Hageman factor) [ Mus musculus (house mouse) ] |
Official Symbol : | F12 |
Synonyms : | HAF; FXII; factor XII; coagulation factor XII; hageman factor |
Gene ID : | 58992 |
mRNA Refseq : | NM_021489.3 |
Protein Refseq : | NP_067464.2 |
UniProt ID : | Q80YC5 |
Products Types
◆ Recombinant Protein | ||
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F12-1833R | Recombinant Rat F12 Protein, His (Fc)-Avi-tagged | +Inquiry |
F12-2040P | Recombinant Pig F12 Protein (20-371 aa), His-tagged | +Inquiry |
F12-3606H | Recombinant Human F12 Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
F12-13H | Native Human Factor beta-XIIa, Biotin Labeled | +Inquiry |
F12-5397H | Active Native Human Coagulation Factor XII (Hageman factor) | +Inquiry |
F12-28805TH | Native Human F12 | +Inquiry |
◆ Lysates | ||
F12-2115HCL | Recombinant Human F12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionAbnormalities in F12 can lead to increased risk of thrombosis and related disorders.
Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.
F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.
Altered F12 activity is associated with inflammation and can influence immune responses.
Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.
Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.
Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.
Customer Reviews (3)
Write a reviewTrustworthy data source. Valuable for our experiments.
Accelerates research progress. Exceptional service provider.
Enables data-driven decisions. A research necessity.
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