Recombinant Pig F12 Protein (20-371 aa), His-tagged
Cat.No. : | F12-2040P |
Product Overview : | Recombinant Pig F12 Protein (20-371 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Partial. |
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Description : | Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). |
Source : | Yeast |
Species : | Pig |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 41.8 kDa |
Protein length : | 20-371 aa |
AA Sequence : | IPPWKDPRKHKVMASEHTVVLTVTG EPCHFPFQYYRQLYYKCIQRGQRGP RPWCATTPNFEKDQRWAYCLEPMKV KDHCNKGNPCQKGGTCVNMPNGPHC ICPDHFTGKHCQKEKCFEPQFLQFF QENEIWHRFEPAGVSKCQCKGPKAQ CKPVASQVCSTNPCLNGGSCLQTEG HRLCRCPTGYAGRLCDVDLKERCYS DRGLSYRGMAQTTLSGAPCQPWASE ATYWNMTAEQALNWGLGDHAFCRNP DNDTRPWCFVWRGDQLSWQYCRLAR CQAPIGEAPPILTPTQSPSEHQDSP LLSREPQPTTQTPSQNLTSAWCAPP EQRGPLPSAGLVGCGQRLRKRLSSL NR |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | F12 coagulation factor XII (Hageman factor) [ Sus scrofa ] |
Official Symbol : | F12 |
Synonyms : | F12; coagulation factor XII; HAF; factor XII; hageman factor; FXII; |
Gene ID : | 397474 |
mRNA Refseq : | NM_214242 |
Protein Refseq : | NP_999407 |
UniProt ID : | O97507 |
Products Types
◆ Recombinant Protein | ||
F12-2005P | Recombinant Pig F12 Protein (20-371 aa), His-tagged | +Inquiry |
F12-1833R | Recombinant Rat F12 Protein, His (Fc)-Avi-tagged | +Inquiry |
F12-2916M | Recombinant Mouse F12 Protein, His (Fc)-Avi-tagged | +Inquiry |
F12-3606H | Recombinant Human F12 Protein, GST-tagged | +Inquiry |
F12-909M | Recombinant Mouse F12 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
F12-5397H | Active Native Human Coagulation Factor XII (Hageman factor) | +Inquiry |
F12-13H | Native Human Factor beta-XIIa, Biotin Labeled | +Inquiry |
F12-28805TH | Native Human F12 | +Inquiry |
◆ Lysates | ||
F12-2115HCL | Recombinant Human F12 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewTrustworthy data source. Valuable for our experiments.
Accelerates research progress. Exceptional service provider.
Enables data-driven decisions. A research necessity.
Q&As (7)
Ask a questionAbnormalities in F12 can lead to increased risk of thrombosis and related disorders.
Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.
F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.
Altered F12 activity is associated with inflammation and can influence immune responses.
Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.
Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.
Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.
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