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Recombinant Pig F12 Protein (20-371 aa), His-tagged

Cat.No. : F12-2005P
Product Overview : Recombinant Pig F12 Protein (20-371 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Partial.
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Description : Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity).
Source : E. coli
Species : Pig
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 43.8 kDa
Protein length : 20-371 aa
AA Sequence : IPPWKDPRKHKVMASEHTVVLTVTG EPCHFPFQYYRQLYYKCIQRGQRGP RPWCATTPNFEKDQRWAYCLEPMKV KDHCNKGNPCQKGGTCVNMPNGPHC ICPDHFTGKHCQKEKCFEPQFLQFF QENEIWHRFEPAGVSKCQCKGPKAQ CKPVASQVCSTNPCLNGGSCLQTEG HRLCRCPTGYAGRLCDVDLKERCYS DRGLSYRGMAQTTLSGAPCQPWASE ATYWNMTAEQALNWGLGDHAFCRNP DNDTRPWCFVWRGDQLSWQYCRLAR CQAPIGEAPPILTPTQSPSEHQDSP LLSREPQPTTQTPSQNLTSAWCAPP EQRGPLPSAGLVGCGQRLRKRLSSL NR
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : F12 coagulation factor XII (Hageman factor) [ Sus scrofa ]
Official Symbol : F12
Synonyms : F12; coagulation factor XII; HAF; factor XII; hageman factor; FXII;
Gene ID : 397474
mRNA Refseq : NM_214242
Protein Refseq : NP_999407
UniProt ID : O97507

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does F12 play in thrombotic disorders? 05/30/2023

Abnormalities in F12 can lead to increased risk of thrombosis and related disorders.

How do genetic variations in the F12 gene affect coagulation and risk of bleeding or clotting disorders? 03/26/2022

Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.

How does F12 interact with other components of the coagulation and fibrinolytic systems? 10/01/2021

F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.

What is the impact of altered F12 activity on inflammation and immune response? 04/28/2021

Altered F12 activity is associated with inflammation and can influence immune responses.

What potential therapeutic applications could arise from targeting F12 in clotting or inflammatory disorders? 12/29/2019

Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.

How does F12 activation initiate the intrinsic pathway of coagulation? 10/05/2018

Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.

What is the primary function of Factor XII (F12) in the blood coagulation cascade? 03/23/2017

Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.

Customer Reviews (3)

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Reviews
06/23/2023

    Trustworthy data source. Valuable for our experiments.

    05/22/2022

      Accelerates research progress. Exceptional service provider.

      03/26/2018

        Enables data-driven decisions. A research necessity.

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