Active Native Human Coagulation Factor XII (Hageman factor)
Cat.No. : | F12-5397H |
Product Overview : | HumanFactor beta-XIIa is a single chain polypeptide activated from homogeneous Human F12 by an autoactivation process with dextran sulfate. |
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Description : | Human F12is generated in vivo by kallikrein cleavage of Factor alpha-XIIa and containsthe catalytic light chain and the C-terminal peptide of the heavy chain of Factoralpha-XIIa. Human Factor beta-XIIa is activated from homogeneous Human FactorXII by an autoactivation process with Dextran Sulfate followed byrepurification to isolate Factor alpha-XIIa and Factor beta-XIIa. Completeactivation is observed on SDSPAGE. |
Source : | Human plasma |
Species : | Human |
Form : | Frozen liquidcontaining 4 mM Sodium acetate Buffer + 0.15 M NaCl, pH 5.3. |
Bio-activity : | Determined byClotting Assay. |
Molecular Mass : | 30 kDa |
Endotoxin : | < 0.1 ng/μg ofprotein.> |
Purity : | ≥95% by SDS-PAGEanalysis. |
Storage : | Store at-80°C. Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles. |
Concentration : | 2.0 mg/ml |
Tag : | Non |
Gene Name : | F12 coagulation factor XII (Hageman factor) [ Homo sapiens ] |
Official Symbol : | F12 |
Synonyms : | F12; coagulation factor XII (Hageman factor); coagulation factor XII; Hageman factor; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; HAF; HAE3; HAEX; |
Gene ID : | 2161 |
mRNA Refseq : | NM_000505 |
Protein Refseq : | NP_000496 |
MIM : | 610619 |
UniProt ID : | P00748 |
Chromosome Location : | 5q33-qter |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem; Intrinsic Pathway, organism-specific biosystem; |
Function : | binding; misfolded protein binding; peptidase activity; protein binding; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
F12-764H | Recombinant Human F12 protein, His-tagged | +Inquiry |
F12-2005P | Recombinant Pig F12 Protein (20-371 aa), His-tagged | +Inquiry |
F12-909M | Recombinant Mouse F12 Protein, His-tagged | +Inquiry |
F12-2040P | Recombinant Pig F12 Protein (20-371 aa), His-tagged | +Inquiry |
F12-2916M | Recombinant Mouse F12 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
F12-13H | Native Human Factor beta-XIIa, Biotin Labeled | +Inquiry |
F12-28805TH | Native Human F12 | +Inquiry |
◆ Lysates | ||
F12-2115HCL | Recombinant Human F12 cell lysate | +Inquiry |
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Not For Human Consumption!
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Write a reviewTrustworthy data source. Valuable for our experiments.
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Enables data-driven decisions. A research necessity.
Q&As (7)
Ask a questionAbnormalities in F12 can lead to increased risk of thrombosis and related disorders.
Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.
F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.
Altered F12 activity is associated with inflammation and can influence immune responses.
Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.
Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.
Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.
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