fbxo3
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  • Official Full Name
  • F-box protein 3
  • Background
  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3 end.
  • Synonyms
  • FBXO3; F-box protein 3; F box only protein 3; F-box only protein 3; FBA; FBX3; F box protein 3; F box protein FBX3; F-box protein FBX3
Cat.#:FBXO3-3929HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBXO3 Protein, GST-tagged
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Cat.#:FBXO3-12794HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBXO3, His-tagged
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Cat.#:FBXO3-2292RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FBXO3 Protein
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Cat.#:FBXO3-1660RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FBXO3 Protein, His-tagged
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Cat.#:FBXO3-2862ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FBXO3
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Cat.#:FBXO3-6300HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FBXO3 293 Cell Lysate
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Involved Pathway

FBXO3 involved in several pathways and played different roles in them. We selected most pathways FBXO3 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
SIGLEC12; RNF123; CREB1B; B2ML; CTSLL; DNM1; LILRB2; CXADR; ASB8; CD300LF
Antigen processing: Ubiquitination &
FBXO44; NPEPPS; RNF111; ASB4; RNF4; BLMH; WWP1; TRIM41; TRIM9; PJA1
Proteasome degradation
WSB1; FBXO44; UBA5; TRIM9; RNF6; ASB10; ASB4; TRAF7; CMTM2A; UBE2J2
Class I MHC mediated antigen processing &
SPSB4; GAN; UBE2F; ERAP2; RNF4; FBXO17; TRIM39; MKRN1; RNF25; LRRC41
presentation
ERAP2; FBXO27; KLHL20; RNF111; NPEPPS; PJA2; CTSL2; RBCK1; RNF25; UBE2L6
Immune System
CLEC6A; CD300LD; TRIM17; NA; CD300LF; SIGIRR; IgG3; IFI27; IRF2; TRIM50

Protein Function

FBXO3 has several biochemical functions, for example, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO3 itself. We selected most functions FBXO3 had, and list some proteins which have the same functions with FBXO3. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein GAP43; C19orf25; TMA16; GOLGA7; RTP3; IL17RA; RELB; HHEX; STAT4; NFAT5
Function ubiquitin-protein transferase activity
Related Protein SIAH1; BRAP; BIRC2; NEDD4L; TRAF5; HUWE1; PRKCQ; FBXO40.1; TRAF4A; PRP19

Interacting Protein

FBXO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO3.
SKP1; tat; HSP90AB1; TNIP3; q99ib8-pro_0000045599; NSS

FBXO3 Related Articles

Kainulainen, M; Habjan, M; et al. Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH. JOURNAL OF VIROLOGY 88:3464-3473(2014).
Mallampalli, RK; Coon, TA; et al. Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation. JOURNAL OF IMMUNOLOGY 191:5247-5255(2013).