Recombinant Full Length Human FBXO3 Protein, C-Flag-tagged

• Cat.No.: FBXO3-1461HFL
• Product Overview: Recombinant Full Length Human FBXO3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 54.4 kDa
• AA Sequence: MAAMETETAPLTLESLPTDPLLLIL SFLDYRDLINCCYVSRRLSQLSSHD PLWRRHCKKYWLISEEEKTQ KNQCWKSLFIDTYSDVGRYIDHYAA IKKAWDDLKKYLEPRCPRMVLSLKE GAREEDLDAVEAQIGCKLPD DYRCSYRIHNGQKLVVPGLLGSMAL SNHYRSEDLLDVDTAAGGFQQRQGL KYCLPLTFCIHTGLSQYIAV EAAEGRNKNEVFYQCPDQMARNPAA IDMFIIGATFTDWFTSYVKNVVSGG FPIIRDQIFRYVHDPECVAT TGDITVSVSTSFLPELSSVHPPHYF FTYRIRIEMSKDALPEKACQLDSRY WRITNAKGDVEEVQGPGVVG EFPIISPGRVYEYTSCTTFSTTSGY MEGYYTFHFLYFKDKIFNVAIPRFH MACPTFRVSIARLEMGPDEY
  EEMEEEEEEEEEEDEDDDSADMDES DEDDEEERRRRVFDVPIRRRRCSRL FTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: FBXO3 F-box protein 3 [ Homo sapiens (human) ]
• Official Symbol: FBXO3
• Synonyms: FBA; FBX3
• Gene ID: 26273
• mRNA Refseq: NM_012175.4
• Protein Refseq: NP_036307.2
• MIM: 609089
• UniProt ID: Q9UK99