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Recombinant Human FBXO3 Protein (1-471 aa), His-tagged

Cat.No. : FBXO3-1731H
Product Overview : Recombinant Human FBXO3 Protein (1-471 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cell Biology. Protein Description: Full Length.
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  • Gene Information
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Description : Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 56.6 kDa
Protein length : 1-471 aa
AA Sequence : MAAMETETAPLTLESLPTDPLLLIL SFLDYRDLINCCYVSRRLSQLSSHD PLWRRHCKKYWLISEEEKTQKNQCW KSLFIDTYSDVGRYIDHYAAIKKAW DDLKKYLEPRCPRMVLSLKEGAREE DLDAVEAQIGCKLPDDYRCSYRIHN GQKLVVPGLLGSMALSNHYRSEDLL DVDTAAGGFQQRQGLKYCLPLTFCI HTGLSQYIAVEAAEGRNKNEVFYQC PDQMARNPAAIDMFIIGATFTDWFT SYVKNVVSGGFPIIRDQIFRYVHDP ECVATTGDITVSVSTSFLPELSSVH PPHYFFTYRIRIEMSKDALPEKACQ LDSRYWRITNAKGDVEEVQGPGVVG EFPIISPGRVYEYTSCTTFSTTSGY MEGYYTFHFLYFKDKIFNVAIPRFH MACPTFRVSIARLEMGPDEYEEMEE EEEEEEEEDEDDDSADMDESDEDDE EERRRRVFDVPIRRRRCSRLF
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : FBXO3 F-box protein 3 [ Homo sapiens ]
Official Symbol : FBXO3
Synonyms : FBXO3; F-box protein 3; FBA; FBX3; DKFZp564B092;
Gene ID : 26273
mRNA Refseq : NM_012175
Protein Refseq : NP_036307
MIM : 609089
UniProt ID : Q9UK99

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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