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FCN2

  • Official Full Name

    ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)

  • Overview

    The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    FCN2; ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); ficolin-2; collagen/fibrinogen domain containing protein 2; EBP 37; FCNL; ficolin B; ficolin 2; hucolin; L ficolin; P35; serum lectin p35; 37 kDa elastin-binding protein; Ficolin beta; OTTHUMP00000022518; RP11-263F14.2; L-ficolin; ficolin-B; ficolin-beta; collagen/fibrinogen domain-containing protein 2; EBP-37;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FCN2-494H Active Recombinant Human Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), His-tagged Mammalian cells His
Human FCN2-4003H Recombinant Human FCN2 Protein, GST-tagged Wheat Germ GST
Human FCN2-613HCL Recombinant Human FCN2 cell lysate N/A
Human FCN2-4765HF Recombinant Full Length Human FCN2 Protein, GST-tagged In Vitro Cell Free System GST 313 amino acids
Human FCN2-2138H Recombinant Human FCN2 Protein (26-313 aa), His-tagged Yeast His 26-313 aa
Human FCN2-2936H-B Recombinant Human FCN2 Protein Pre-coupled Magnetic Beads HEK293
Human FCN2-4542H Recombinant Human FCN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FCN2-1475H Recombinant Human FCN2 Protein, His-tagged E.coli N-His Thr47-Asn300
Human FCN2-4411H Recombinant Human FCN2 protein, His-tagged E.coli His 26-313aa
Human FCN2-2936H Recombinant Human FCN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FCN2-1682R Recombinant Rhesus monkey FCN2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FCN2-1504R Recombinant Rhesus Macaque FCN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FCN2-1504R-B Recombinant Rhesus Macaque FCN2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FCN2 Related Articles
  • FCN2 Related Research Area

FCN2 involved in several pathways and played different roles in them. We selected most pathways FCN2 participated on our site, such as Complement cascade, Creation of C4 and C2 activators, Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement cascadeCFHL2;CFHL3;FCN3;CFHL1;IgG3;CFHL4;HBL3;FCN2;BFB
Creation of C4 and C2 activatorsHBL3;C1rb;MASP2;IGKC;FCN1;FCN2;IGLC2;IgG3;IGKV1-5
Ficolins bind to repetitive carbohydrate structures on the target cell surfaceFCN1;MASP2;FCN2;FCN3
Immune SystemNOD1;LAIR1;CLEC2B;KIF5A;WIPF3;NCR3LG1;NLRC5;ASB3;KIF4A
Initial triggering of complementC1rb;CFD;CRP;GZMM;BFB;MASP2;FCN3;FCN2;FCN1
Innate Immune SystemRIPK3;DDOST;NLRP4;ACTR2B;IRF2;CFHL2;BTR02;RNF135;CHST13
Lectin pathway of complement activationFCN3;FCN2;HBL3;FCN1

FCN2 has several biochemical functions, for example, antigen binding, calcium-dependent protein binding, mannan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN2 itself. We selected most functions FCN2 had, and list some proteins which have the same functions with FCN2. You can find most of the proteins on our site.

Function Related Protein
antigen bindingHNRNPM;Ighg2b;CD40;IGKV1-5;IGLL1;SLAMF1;Ighg2a;LAG3;LILRA1
calcium-dependent protein bindingVLDLR;FCN2;ANXA2;TNNI3;KOP;MMP13;CASQ2;RAC3;STX2
mannan bindingFCN2;REG4
protein bindingTRIM63;CYGB;CREB3L1;OLA1;DOLK;GUCY2C;SMAD4;ANXA4;ANTXR1
proteoglycan bindingCTSK;FCN2;CECR1;THBS1;UBE4A;CTSS;CTSB;CECR1A;COL5A1

FCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN2.

LRP1; CRP; q9wmx2-pro_0000037550

Metzger, ML; Michelfelder, I; et al. Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 179:256-264(2015).
Osthoff, M; Irungu, E; et al. Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine. VACCINE 32:4772-4777(2014).
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