FCN2

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FCN2

Official Full Name ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
Background The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms FCN2; ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); ficolin-2; collagen/fibrinogen domain containing protein 2; EBP 37; FCNL; ficolin B; ficolin 2; hucolin; L ficolin; P35; serum lectin p35; 37 kDa elastin-binding protein; Ficolin beta; OTTHUMP00000022518; RP11-263F14.2; L-ficolin; ficolin-B; ficolin-beta; collagen/fibrinogen domain-containing protein 2; EBP-37
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293T
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FCN2-2138H Recombinant Human FCN2 Protein (26-313 aa), His-tagged Yeast His
    Human FCN2-4542H Recombinant Human FCN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FCN2-4003H Recombinant Human FCN2 Protein, GST-tagged Wheat Germ GST
    Human FCN2-494H Recombinant Human Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), His-tagged NS0 His
    Human FCN2-613HCL Recombinant Human FCN2 cell lysate N/A
    Rhesus Macaque FCN2-1682R Recombinant Rhesus monkey FCN2 Protein, His-tagged Mammalian Cell His

    FCN2 involved in several pathways and played different roles in them. We selected most pathways FCN2 participated on our site, such as Complement cascade, Creation of C4 and C2 activators, Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement cascade CFHL3; IGKC; BFB; CFHL2; CRP; CR1; CFHL1; CFHL4; FCN2; CFD
    Creation of C4 and C2 activators FCN2; CRP; IGLC2; FCN3; IGKC; C1rb; IgG3; HBL3; MASP2; IGKV1-5
    Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN1; FCN3; FCN2; MASP2
    Immune System TRIM8; AGER; CR1; GBP5; TRIM6; NLRP4B; MKRN1; KIF18A; WIPF3; TXNIPB
    Initial triggering of complement IgG3; HBL3; MASP2; CFD; GZMM; FCN2; FCN3; C1rb; CRP; BFB
    Innate Immune System TAX1BP1; DDOST; PANX1; LGALS3; HBL3; FAM49BA; MYO1C; IRAK3; POLR3F; DEFB1
    Lectin pathway of complement activation FCN2; FCN3; HBL3; FCN1

    FCN2 has several biochemical functions, for example, antigen binding, calcium-dependent protein binding, mannan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN2 itself. We selected most functions FCN2 had, and list some proteins which have the same functions with FCN2. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding LILRB4; IGHM; PPP2R1A; Ighg2b; FCN2; CD40; IL7R; Ighg; TSPAN4; HNRNPM
    calcium-dependent protein binding CHP; SEC31A; TNNC1; S100P; MYO1D; ANXA1; CPNE3; CALM3; CD209A; SYT1
    mannan binding REG4; FCN2
    protein binding TTYH2; ALDH1A2; RAB21; PKP2; NOX1; BCL2L13; ERP29; UPF3B; TOMM7; KRT17
    proteoglycan binding NID1; COL5A1; CTSB; SLIT2; CECR1; UBE4A; THBS1; CTSS; FCN2; CECR1A

    FCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN2.

    LRP1; CRP; q9wmx2-pro_0000037550

    Metzger, ML; Michelfelder, I; et al. Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 179:256-264(2015).
    Osthoff, M; Irungu, E; et al. Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine. VACCINE 32:4772-4777(2014).

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