fgf20
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  • Official Full Name
  • Fgf20 fibroblast growth factor 20
  • Background
  • Fibroblast growth factor 21(FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic -cells. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance.
  • Synonyms
  • FGF20; fibroblast growth factor 20; FGF-20;
Cat.#:FGF20-12869HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF20, GST-tagged
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Cat.#:FGF20-15HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF20 protein, His-tagged
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Cat.#:FGF20-178HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 20
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Cat.#:FGF20-19HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF20 protein, His-tagged
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Cat.#:FGF20-331HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF20 Protein
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Cat.#:FGF20-5848MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGF20 Protein
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Cat.#:FGF20-2332RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGF20 Protein
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Cat.#:FGF20-6243HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FGF20 293 Cell Lysate
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Involved Pathway

FGF20 involved in several pathways and played different roles in them. We selected most pathways FGF20 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
AKT3A; TRAF2; PLA2G4D; FLNB; GNG12; CACNA1C; TP53; RPS6KA3A; MAPKAPK3; CACNA1BA
Ras signaling pathway
RASSF5; HRAS; RASA4; GNG8; RASAL2; PIK3R2; PRKCG; Fasl; VEGFB; GNG10
Rap signaling pathway
ITGB1; FGF20; TEK; MAPK12; PARD6B; FGF10; INS1; MAP2K1; AKT1; THBS1
PIK-Akt signaling pathway
GSK3B; LPAR5; RPTOR; IFNA6; MAPK3; CRTC2; IFNAR2; RPS6KB2; HRAS; KRAS
Regulation of actin cytoskeleton
PIP5K1A; PIK3CG; FGF16; ITGAX; WASLA; FGF4; FGF20; CDC42L2; IQGAP2; MYLPFA
Pathways in cancer
BAD; AHA-1; HSP90AB1; AGTR1A; SMAD3; CYCS; HSP90AA1; CXCR4; LAMC1; PTK2
Melanoma
FGF18; FGF1; FGF19; FGF8; FGF21; ARAF; FGF2; PDGFC; FGF16; FGF13

Protein Function

FGF20 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF20 itself. We selected most functions FGF20 had, and list some proteins which have the same functions with FGF20. You can find most of the proteins on our site.
Function
Related Protein
Function fibroblast growth factor receptor binding
Related Protein FGF21; FGF8A; FGF10; FGF20B; FGF6B; FGF5; FGF22; FGF2; FGF16; FGF18B
Function growth factor activity
Related Protein FGF11; GDF7; MANF; FGF5; KLK1B3; LEFTY2; LEFTY1; GDF6; FGF12B; INHBB

FGF20 Related Articles

Munnamalai, V; Hayashi, T; et al. Notch Prosensory Effects in the Mammalian Cochlea Are Partially Mediated by Fgf20. JOURNAL OF NEUROSCIENCE 32:12876-12884(2012).
Hayashi, T; Ray, CA; et al. Fgf20 is required for sensory epithelial specification in the developing cochlea. JOURNAL OF NEUROSCIENCE 28:5991-5999(2008).