Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

FGF3

Official Full Name

fibroblast growth factor 3
Overview

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
Synonyms

FGF3; fibroblast growth factor 3; fibroblast growth factor 3 (murine mammary tumor virus integration site (v int 2) oncogene homolog) , INT2; HBGF 3; INT 2 proto oncogene protein; murine mammary tumor virus integration site 2; mouse; oncogene INT2; V INT2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

E. coli
E.coli
HEK293
Mammalian Cell

Tag

C
His
His (Fc)
Avi
His(C
ter)
Met
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FGF3-518H	Active Recombinant Human Fibroblast Growth Factor 3	E.coli	N/A		Inquiry
Human	FGF3-560H	Active Recombinant Human FGF3	E.coli	Met	Asp28-Arg212	Inquiry
Human	FGF3-8153H	Recombinant Human FGF3 protein, His-tagged	E.coli	His	Tyr154~Ser232 (Accession# P11487)	Inquiry
Human	FGF3-6240HCL	Recombinant Human FGF3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FGF3-037H	Active Recombinant Human FGF3 Protein	E. coli			Inquiry
Human	FGF3-84H	Recombinant Active Human FGF3 Protein, His-tagged(C-ter)	E.coli	His(C-ter)		Inquiry
Human	FGF3-1494H	Recombinant Human FGF3 Protein, His-tagged	E.coli	N-His	Ala18-His239	Inquiry
Human	FGF3-03H	Active Recombinant Human FGF3 Protein, Pre-aliquoted	E.coli		Asp28-Arg212, with an N-terminal Met	Inquiry
Human	FGF3-1493H	Recombinant Human FGF3 Protein, His-tagged	E.coli	N-His	Ala18-His239	Inquiry
Human	FGF3-1426H	Active Recombinant Human FGF3 protein, His-tagged	E.coli	His	Ala18-His239	Inquiry
Human	FGF3-95H	Active Recombinant Human FGF3 Protein (Asp28-Arg212), C-His tagged, Animal-free, Carrier-free	E.coli	C-His	Asp28-Arg212	Inquiry
Rhesus Macaque	FGF3-1700R	Recombinant Rhesus monkey FGF3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	FGF3-1522R	Recombinant Rhesus Macaque FGF3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	FGF3-1522R-B	Recombinant Rhesus Macaque FGF3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	FGF3-8882Z	Recombinant Zebrafish FGF3	Mammalian Cell	His		Inquiry
Chicken	FGF3-6879C	Recombinant Chicken FGF3	Mammalian Cell	His		Inquiry

FGF3 involved in several pathways and played different roles in them. We selected most pathways FGF3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	GNG12A;NTRK1;FGF8;AKT2;MAP2K2;FGF14;FLNC;MKNK2B;MAP2K1
Ras signaling pathway	PRKCG;GRB2;PLCG2;FGFR1;FGF4;PAK6;PIK3CG;GNB3;GNGT1
Rap signaling pathway	RALB;MAPK12;ARAP3;FGFR1;PLCB3;BRAF;ACTB;NGFR;IGF1R
PIK-Akt signaling pathway	ITGA8;AKT2;SGK3;IFNB1;IL4R;CD19;IL2RB;KIT;INS1
Regulation of actin cytoskeleton	ITGB8;FGF11;PIK3R1;PIP5K1BA;VAV2;PDGFA;BDKRB2;FGF13;DIAP1
Pathways in cancer	GNG13;MECOM;PTGER3;FGF10;MDM2;TCF7;TCF7L2;LAMA5;TFG
Melanoma	HRAS;FGF4;FGF22;ARAF;FGF11;AKT1;BRAF;FGF13;RAF1

FGF3 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF3 itself. We selected most functions FGF3 had, and list some proteins which have the same functions with FGF3. You can find most of the proteins on our site.

Function	Related Protein
fibroblast growth factor receptor binding	FGF22;FGF18A;FGF8A;FGF18B;FGF5;FGF10;Fgf15;FGF10B;FGF1A
growth factor activity	FGF20B;TYMP;CSF3;NRG4;BMP16;FGF17;GPI;AMH;BMP3
protein binding	SEC14L4;GNL3;SYVN1;VPS28;RPRD1B;MRPL23;HSP90AA1.2;SIRT6;RHBDL1

FGF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF3.

Rashid, H; Ma, CY; et al. Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. CONNECTIVE TISSUE RESEARCH 55:83-87(2014).

Nakao, Y; Mitsuyasu, T; et al. Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway. INTERNATIONAL JOURNAL OF ONCOLOGY 43:1377-1384(2013).

Oncoprotein-Growth Factors