FGF8 Protein, fibroblast growth factor 8 (androgen-induced)

FGF8

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FGF8

Official Full Name fibroblast growth factor 8 (androgen-induced)
Background The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.
Synonyms FGF8; fibroblast growth factor 8 (androgen-induced); fibroblast growth factor 8; AIGF; androgen-induced growth factor; heparin-binding growth factor 8; KAL6; FGF-8; HBGF-8; MGC149376
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Met
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGF8-647H Recombinant Human FGF8 Protein (Gln23-Arg215), Met E.coli N/A
    Human FGF8-28885TH Recombinant Human FGF8 E.coli N/A
    Human FGF8-348H Recombinant Human FGF8, Met-tagged E.coli Met
    Human FGF8-374H Recombinant Human Fibroblast Growth Factor 8 (Androgen-induced) HEK293 N/A
    Human FGF8-6234HCL Recombinant Human FGF8 293 Cell Lysate HEK293 N/A
    Human FGF8-771H Recombinant Human FGF8 Protein E.coli N/A
    Human FGF8-789H Recombinant Human FGF8 Protein, His-tagged E.coli His
    Mouse Fgf8-539M Recombinant Mouse Fgf8 protein E.coli N/A
    Chicken FGF8-1997C Recombinant Chicken FGF8 Mammalian Cell His

    FGF8 involved in several pathways and played different roles in them. We selected most pathways FGF8 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway STK4; PPM1BA; SRFA; MAPK12A; MAP2K3; FGF16; MECOM; Fgf15; KCNA3; TRP53
    Ras signaling pathway CSF1; PLA2G12A; Fgf15; RAC2; INSR; RRAS2; FGF13; SHC1; FGFR4; MAPK1
    Rap signaling pathway RAP1B; PARD6B; AKT2; PIK3R2; RRAS; FGF2; SRC; CALM3; FGF4; MAPK1
    PIK-Akt signaling pathway Kitl; TNC; KRAS; MLST8; GNGT2; STK11; ITGA7; PDPK1; LAMA1; IRS1
    Regulation of actin cytoskeleton TMSB4Y; ACTB; CHRM2A; ENAH; TMSB4X; MYL2B; ARPC4L; MYL12.2; ACTB1; TMSB
    Pathways in cancer LPAR3; LAMA1; TCF7; WNT16; CXCL12; BRAF; PIK3CA; FZD5; PGF; TFG
    Melanoma FGF11; IGF1; FGF18; FGF3; MAP2K1; PIK3CB; FGF16; FGF1; PDGFB; TP53

    FGF8 has several biochemical functions, for example, chemoattractant activity, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF8 itself. We selected most functions FGF8 had, and list some proteins which have the same functions with FGF8. You can find most of the proteins on our site.

    Function Related Protein
    chemoattractant activity SAA2; CCL3; NTF3; MIF; VHL; SCG2; FIGF; VEGFC; HMGB1; HMGB2
    fibroblast growth factor receptor binding FGF3; FGF4; FGF6A; FRS3; FGF20A; FGF21; FGF8B; FGF20B; FGF1; Fgf15
    growth factor activity NODAL; JAG1; OSM; INHA; GDF6B; MSTN; FBRS; OSGIN1; FGF8A; GMFB
    type 1 fibroblast growth factor receptor binding NPTN; FGF18; FGF8; FGF17
    type 2 fibroblast growth factor receptor binding FGF10; FGF7; FGF18; FGF8; FGF17

    FGF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF8.

    FGFR1; FGFR2

    Sautter, NB; Delaney, KL; et al. Tissue remodeling gene expression in a murine model of chronic rhinosinusitis. LARYNGOSCOPE 122:711-717(2012).
    Sato, A; Scholl, AM; et al. FGF8 signaling is chemotactic for cardiac neural crest cells. DEVELOPMENTAL BIOLOGY 354:18-30(2011).

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